Arcadia Science

Latest preprint reviews

1. Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

   This article has 27 authors:

   1. Sung Yun Park
   2. Arlo Sheridan
   3. Bobae An
   4. Erin Jarvis
   5. Julia Lyudchik
   6. William Patton
   7. Jun Y. Axup
   8. Stephanie W. Chan
   9. Hugo G.J. Damstra
   10. Daniel Leible
   11. Kylie S. Leung
   12. Clarence A. Magno
   13. Aashir Meeran
   14. Julia M. Michalska
   15. Franz Rieger
   16. Claire Wang
   17. Michelle Wu
   18. George M. Church
   19. Jan Funke
   20. Todd Huffman
   21. Kathleen G.C. Leeper
   22. Sven Truckenbrodt
   23. Johan Winnubst
   24. Joergen M.R. Kornfeld
   25. Edward S. Boyden
   26. Samuel G. Rodriques
   27. Andrew C. Payne

   Reviewed by Arcadia Science

2. Extracellular adenosine deamination primes tip organizer development in Dictyostelium

   This article has 2 authors:

   1. Pavani Hathi
   2. Baskar Ramamurthy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     During the development of the unicellular eukaryote Dictyostelium discoideum, cells aggregate into mounds, which then form protrusions called tips, and the tips then become the front of migrating slugs and the top of fruiting bodies. This valuable study identifies a protein called adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation, and the authors convincingly show that ADGF catalyses the formation of ammonia from adenosine, allowing ammonia to initiate tip formation, and they then elucidate pathways upstream and downstream from ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also regulate development in a similar manner.

   Reviewed by Arcadia Science, eLife

3. Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

   This article has 19 authors:

   1. Bruno A. Benitez
   2. Clare E. Wallace
   3. Maulikkumar Patel
   4. Niko-Petteri Nykanen
   5. Carla M. Yuede
   6. Samantha L. Eaton
   7. Cyril Pottier
   8. Arda Cetin
   9. Matthew Johnson
   10. Mia T. Bevan
   11. Woodrow D. Gardiner
   12. Hannah M. Edwards
   13. Brookelyn M. Doherty
   14. Ryan T. Harrigan
   15. Dominic Kurian
   16. Thomas M. Wishart
   17. Colin Smith
   18. John R. Cirrito
   19. Mark S. Sands

   Reviewed by Arcadia Science

4. Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

   This article has 2 authors:

   1. Maurice Deserno
   2. Katarzyna Bozek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces a self-supervised machine learning method to classify C. elegans postures and behaviors directly from video data, offering an alternative to the skeleton-based approaches that rely on often error-prone tracking. This novel approach holds promise for advancing ethology research. That said, the strength of evidence is currently incomplete, as key aspects - including measuring head-tail orientation, increased behavioral interpretability, and quantitative comparisons to established methods - are underdeveloped and would benefit from further validation.

   Reviewed by Arcadia Science, eLife

5. The reproductive microbiome inhibits pollen germination in milkweed

   This article has 8 authors:

   1. Harmony J. Dalgleish
   2. Joshua R. Puzey
   3. Katie Barlow
   4. Olivia Cunningham
   5. Elizabeth M. Davies
   6. Hannah Machiorlete
   7. Geneva Waynick
   8. Kurt E. Williamson

   Reviewed by Arcadia Science

6. Isolation of functional lysosomes from skeletal muscle

   This article has 4 authors:

   1. Thulasi Mahendran
   2. Anastasiya Kuznyetsova
   3. Neushaw Moradi
   4. David A. Hood

   Reviewed by Arcadia Science

7. Leaffooted bugs enrich local soil with their horizontally acquired symbiont

   This article has 3 authors:

   1. Bibek Singh Parajuli
   2. John Teodosio
   3. Alison Ravenscraft

   Reviewed by Arcadia Science

8. Predicting functional constraints across evolutionary timescales with phylogeny-informed genomic language models

   This article has 8 authors:

   1. Chengzhong Ye
   2. Gonzalo Benegas
   3. Carlos Albors
   4. Jianan Canal Li
   5. Sebastian Prillo
   6. Peter D. Fields
   7. Brian Clarke
   8. Yun S. Song

   Reviewed by Arcadia Science

9. Scaling down protein language modeling with MSA Pairformer

   This article has 5 authors:

   1. Yo Akiyama
   2. Zhidian Zhang
   3. Milot Mirdita
   4. Martin Steinegger
   5. Sergey Ovchinnikov

   Reviewed by Arcadia Science

10. The title and authors for this article are not available from our external data provider yet:
    10.1101/2025.09.19.677313