Sexual and Reproductive Health

  1. Identification of Novel Syncytiotrophoblast Membrane Extracellular Vesicles Derived Protein Biomarkers in Early-onset Preeclampsia: A Cross-Sectional Study

    1. Toluwalase Awoyemi
    2. Shuhan Jiang
    3. Bríet Bjarkadóttir
    4. Maryam Rahbar
    5. Prasanna Logenthiran
    6. Gavin Collett
    7. Wei Zhang
    8. Adam Cribbs
    9. Ana Sofia Cerdeira
    10. Manu Vatish

    • Curated by eLife

      eLife assessment

      This study presents valuable findings that could be utilized for identifying women at risk for preeclampsia before the onset of the disease. The novel aspect of this study lies in the utilization of exosomes of two different sizes. The data are solid: the methods, data, and analysis broadly support the claims. This work will be of interest to medical researchers and clinicians who work on preeclampsia and women's health.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  2. Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

    1. Hui-Juan Jin
    2. Yong Fan
    3. Xiaoyu Yang
    4. Yue Dong
    5. Xiao-Zhen Zhang
    6. Xin-Yan Geng
    7. Zheng Yan
    8. Ling Wu
    9. Meng Ma
    10. Bin Li
    11. Qifeng Lyu
    12. Yun Pan
    13. Mingxi Liu
    14. Yanping Kuang
    15. Su-Ren Chen

    • Curated by eLife

      eLife assessment

      Spermiogenesis is a complex process allowing the emergence of specific sperm organelle, including the acrosome, a sperm giant vesicle of secretion. This important study reports the key role of Cylicin-1 in acrosome biogenesis and identifies the molecular partners necessary for acrosome anchoring. The compelling demonstration is based on infertile patient samples and two animal models. Overall, this provides results that will be invaluable to the male reproduction community, including scientists and andrologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS

    1. Elisabet Stener-Victorin
    2. Gustaw Eriksson
    3. Man Mohan Shrestha
    4. Valentina Rodriguez Paris
    5. Haojiang Lu
    6. Jasmine Banks
    7. Manisha Samad
    8. Charlène Perian
    9. Baptiste Jude
    10. Viktor Engman
    11. Roberto Boi
    12. Emma Nilsson
    13. Charlotte Ling
    14. Jenny Nyström
    15. Ingrid Wernstedt Asterholm
    16. Nigel Turner
    17. Johanna Lanner
    18. Anna Benrick

    • Curated by eLife

      eLife assessment

      This important work employed global proteomic and phosphorylation site analysis to examine adipose tissue and skeletal muscle samples collected at baseline from a sample of 10 women, including those with and without PCOS, both before and after 5 weeks of electrical stimulation treatment. This work significantly enhances our knowledge by demonstrating that women with PCOS who exhibit protein hyperandrogenicity have elevated extramyocellular lipid levels and a decreased number of oxidative insulin-sensitive type I muscle fibers. The convincing evidence supporting these conclusions makes this research of broad interest not only to scientists but also to clinicians.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Acute dorsal genital nerve stimulation increases subjective arousal in women with and without spinal cord injury: a preliminary investigation

    1. Elizabeth C. Bottorff
    2. Priyanka Gupta
    3. Giulia M. Ippolito
    4. Mackenzie B. Moore
    5. Gianna M. Rodriguez
    6. Tim M. Bruns

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. Changes in Solo and Partnered Sexual Behaviors during the COVID-19 Pandemic: Findings from a U.S. Probability Survey

    1. Devon J. Hensel
    2. Molly Rosenberg
    3. Maya Luetke
    4. Tsung-chieh Fu
    5. Debby Herbenick

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Voices from the frontline: findings from a thematic analysis of a rapid online global survey of maternal and newborn health professionals facing the COVID-19 pandemic

    1. Aline Semaan
    2. Constance Audet
    3. Elise Huysmans
    4. Bosede Afolabi
    5. Bouchra Assarag
    6. Aduragbemi Banke-Thomas
    7. Hannah Blencowe
    8. Séverine Caluwaerts
    9. Oona Maeve Renee Campbell
    10. Francesca L Cavallaro
    11. Leonardo Chavane
    12. Louise Tina Day
    13. Alexandre Delamou
    14. Therese Delvaux
    15. Wendy Jane Graham
    16. Giorgia Gon
    17. Peter Kascak
    18. Mitsuaki Matsui
    19. Sarah Moxon
    20. Annettee Nakimuli
    21. Andrea Pembe
    22. Emma Radovich
    23. Thomas van den Akker
    24. Lenka Benova

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. SARS–CoV-2 infection of the placenta

    1. Hillary Hosier
    2. Shelli F. Farhadian
    3. Raffaella A. Morotti
    4. Uma Deshmukh
    5. Alice Lu-Culligan
    6. Katherine H. Campbell
    7. Yuki Yasumoto
    8. Chantal B.F. Vogels
    9. Arnau Casanovas-Massana
    10. Pavithra Vijayakumar
    11. Bertie Geng
    12. Camila D. Odio
    13. John Fournier
    14. Anderson F. Brito
    15. Joseph R. Fauver
    16. Feimei Liu
    17. Tara Alpert
    18. Reshef Tal
    19. Klara Szigeti-Buck
    20. Sudhir Perincheri
    21. Christopher Larsen
    22. Aileen M. Gariepy
    23. Gabriela Aguilar
    24. Kristen L. Fardelmann
    25. Malini Harigopal
    26. Hugh S. Taylor
    27. Christian M. Pettker
    28. Anne L. Wyllie
    29. Charles Dela Cruz
    30. Aaron M. Ring
    31. Nathan D. Grubaugh
    32. Albert I. Ko
    33. Tamas L. Horvath
    34. Akiko Iwasaki
    35. Uma M. Reddy
    36. Heather S. Lipkind

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study

    1. Ling Ma
    2. Wen Xie
    3. Danyang Li
    4. Lei Shi
    5. Yanhong Mao
    6. Yao Xiong
    7. Yuanzhen Zhang
    8. Ming Zhang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Development and evaluation of a live birth prediction model for evaluating human blastocysts from a retrospective study

    1. Hang Liu
    2. Zhuoran Zhang
    3. Yifan Gu
    4. Changsheng Dai
    5. Guanqiao Shan
    6. Haocong Song
    7. Daniel Li
    8. Wenyuan Chen
    9. Ge Lin
    10. Yu Sun

    • Curated by eLife

      eLife assessment

      This manuscript provides important findings that have practical implications for reproductive medicine and would be of interest to IVF specialists. Based on the compelling strength of evidence, the authors present significant results on improving the predictive value of the live birth model based on blastocyst evaluation and clinical features. However, some methodological information should be added to improve the reproducibility of the study results.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency

    1. Roberto Oleari
    2. Antonella Lettieri
    3. Stefano Manzini
    4. Alyssa Paganoni
    5. Valentina André
    6. Paolo Grazioli
    7. Marco Busnelli
    8. Paolo Duminuco
    9. Antonio Vitobello
    10. Christophe Philippe
    11. Varoona Bizaoui
    12. Helen L. Storr
    13. Federica Amoruso
    14. Fani Memi
    15. Valeria Vezzoli
    16. Valentina Massa
    17. Peter Scheiffele
    18. Sasha R. Howard
    19. Anna Cariboni

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity