Physiology

Accounting for body mass effects in the estimation of field metabolic rates from body acceleration

1. Evan E. Byrnes
2. Karissa O. Lear
3. Lauran R. Brewster
4. Nicholas M. Whitney
5. Matthew J. Smukall
6. Nicola J. Armstrong
7. Adrian C. Gleiss

Reviewed by ScreenIT

Quality of Life and Depressive Symptoms Among Peruvian University Students During the COVID-19 Pandemic

1. Joel Figueroa-Quiñones
2. Julio Cjuno
3. Daniel Machay-Pak
4. Miguel Ipanaqué-Zapata

Reviewed by ScreenIT

Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ

1. Subhayan Sur
2. Mousumi Khatun
3. Robert Steele
4. T. Scott Isbell
5. Ranjit Ray
6. Ratna B. Ray

Reviewed by ScreenIT

SARS-COV-2 induced Diarrhea is inflammatory, Ca ²⁺ Dependent and involves activation of calcium activated Cl channels

1. Mark Donowitz
2. Chung-Ming Tse
3. Karol Dokladny
4. Manmeet Rawat
5. Ivy Horwitz
6. Chunyan Ye
7. Alison Kell
8. Ruxian Lin
9. Sun Lee
10. Chenxu Guo
11. Shang Jui Tsai
12. Andrea Cox
13. Stephen Gould
14. Julie In
15. Steven Bradfute
16. Nicholas C. Zachos
17. Olga Kovbasnjuk

Reviewed by ScreenIT

N-Glycosylation Network Construction and Analysis to Modify Glycans on the Spike (S) Glycoprotein of SARS-CoV-2

1. Sridevi Krishnan
2. Giri P. Krishnan

Reviewed by ScreenIT

Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

1. Julia Stokes
2. Arielle Freed
3. Rebecca Bornstein
4. Kevin N Su
5. John Snell
6. Amanda Pan
7. Grace X Sun
8. Kyung Yeon Park
9. Sangwook Jung
10. Hailey Worstman
11. Brittany M Johnson
12. Philip G Morgan
13. Margaret M Sedensky
14. Simon C Johnson

• Curated by eLife

  Evaluation Summary:

  This manuscript reports that Volatile anesthetics VA induce a rapid depletion of circulating ß-HB and the induction of hypoglycemia by VA in neonates, but not in adults. The phenomenon is very interesting and robust, however it has already been described. Whats new here is that through a metabolomics analysis they demonstrate a role of ACC and CPT1 in this phenomenon.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

1. Yunlu Xue
2. Sean K Wang
3. Parimal Rana
4. Emma R West
5. Christin M Hong
6. Helian Feng
7. David M Wu
8. Constance L Cepko

• Curated by eLife

  Evaluation Summary:

  This authors used AAV in mouse retinas to express several candidate genes that they thought might have favorable effects on cone metabolism and therefore make cones more robust to stress caused by genetic deficiencies. Txnip is the most effective at prolonging cones survival and a combo of HK and PFK is the most effective at shortening cone survival. The investigators evaluated effects of specific mutations in Txnip with known biochemical effects. Their general conclusion is that Txnip may be enhancing mitochondrial function and ATP production and it may allow cones to use alternative fuels more effectively. This is an interesting and informative set of findings and it is presented and discussed in the context of what currently is known about retina metabolism and its influences on photoreceptor survival.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.)

Reviewed by eLife

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

1. Cheng-Chia Tang
2. Christian D Castro Andrade
3. Maureen J O'Meara
4. Sung-Hee Yoon
5. Tadatoshi Sato
6. Daniel J Brooks
7. Mary L Bouxsein
8. Janaina da Silva Martins
9. Jinhua Wang
10. Nathanael S Gray
11. Barbara Misof
12. Paul Roschger
13. Stephane Blouin
14. Klaus Klaushofer
15. Annegreet Velduis-Vlug
16. Yosta Vegting
17. Clifford J Rosen
18. Daniel O'Connell
19. Thomas B Sundberg
20. Ramnik J Xavier
21. Peter Ung
22. Avner Schlessinger
23. Henry M Kronenberg
24. Rebecca Berdeaux
25. Marc Foretz
26. Marc N Wein

• Curated by eLife

  Evaluation Summary:

  This is a very interesting, novel and informative study. The effects of the inhibitor on CSF1R inhibition are convincing and provide a compelling explanation for the net effects of the compound on the skeleton. The study opens the way for another possible oral therapeutic for osteoporosis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

1. Torsten Dahlén
2. Mark Clements
3. Jingcheng Zhao
4. Martin L Olsson
5. Gustaf Edgren

• Curated by eLife

  Evaluation Summary:

  In this manuscript, Dahlen et al. agnostically survey a large transfusion database in Sweden to investigate the association between ABO and RhD blood group and disease occurrence for a large number of clinical phenotypes. The data reported are purely epidemiological associations, with no direct insight into biological mechanism. Nonetheless, these data are a valuable resource for the research community, and offer the potential for a number of important biologic hypotheses and insights for investigation in the future.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

tTARGIT AAVs: A sensitive and flexible method to manipulate intersectional neuronal populations

1. Paul V. Sabatini
2. Jine Wang
3. Alan C. Rupp
4. Alison H. Affinati
5. Jonathan N. Flak
6. Chien Li
7. David P. Olson
8. Martin G. Myers

• Curated by eLife

  Evaluation Summary:

  The combination of Cre and Flp recombinase dependent system is powerful in manipulating specific intersectional neurons and has been successfully used in many systems. However, the system cannot express target genes sufficiently in some neurons, e.g., the LepRb VMH neurons. This paper solved this problem. It is therefore an important technical advance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife