Physiology

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

1. Xinle Zou
2. Sri Karthika Shanmugam
3. Scott A Kanner
4. Kevin J Sampson
5. Robert S Kass
6. Henry M Colecraft

• Curated by eLife

  eLife assessment

  This important study provides a substantial advance with a method by which a protein target resistant to therapeutic approaches can be uniquely modulated by a cellular protein kinase ferried by nanobodies to a precise molecular site of recruitment. Evidence for this major claim is compelling, but evidence for some of the minor claims seems incomplete. The work will be of broad interest to cell biologists, cardiovascular researchers, and drug developers.

Reviewed by eLife

Personalized Virus Load Curves of SARS-CoV-2 Infection

1. Thomas Hillen
2. Carlos Contreras
3. Jay M. Newby

Reviewed by ScreenIT

Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19

1. Dylan C. Sarver
2. G. William Wong

Reviewed by ScreenIT

Accounting for body mass effects in the estimation of field metabolic rates from body acceleration

1. Evan E. Byrnes
2. Karissa O. Lear
3. Lauran R. Brewster
4. Nicholas M. Whitney
5. Matthew J. Smukall
6. Nicola J. Armstrong
7. Adrian C. Gleiss

Reviewed by ScreenIT

Quality of Life and Depressive Symptoms Among Peruvian University Students During the COVID-19 Pandemic

1. Joel Figueroa-Quiñones
2. Julio Cjuno
3. Daniel Machay-Pak
4. Miguel Ipanaqué-Zapata

Reviewed by ScreenIT

Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ

1. Subhayan Sur
2. Mousumi Khatun
3. Robert Steele
4. T. Scott Isbell
5. Ranjit Ray
6. Ratna B. Ray

Reviewed by ScreenIT

SARS-COV-2 induced Diarrhea is inflammatory, Ca ²⁺ Dependent and involves activation of calcium activated Cl channels

1. Mark Donowitz
2. Chung-Ming Tse
3. Karol Dokladny
4. Manmeet Rawat
5. Ivy Horwitz
6. Chunyan Ye
7. Alison Kell
8. Ruxian Lin
9. Sun Lee
10. Chenxu Guo
11. Shang Jui Tsai
12. Andrea Cox
13. Stephen Gould
14. Julie In
15. Steven Bradfute
16. Nicholas C. Zachos
17. Olga Kovbasnjuk

Reviewed by ScreenIT

N-Glycosylation Network Construction and Analysis to Modify Glycans on the Spike (S) Glycoprotein of SARS-CoV-2

1. Sridevi Krishnan
2. Giri P. Krishnan

Reviewed by ScreenIT

Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

1. Julia Stokes
2. Arielle Freed
3. Rebecca Bornstein
4. Kevin N Su
5. John Snell
6. Amanda Pan
7. Grace X Sun
8. Kyung Yeon Park
9. Sangwook Jung
10. Hailey Worstman
11. Brittany M Johnson
12. Philip G Morgan
13. Margaret M Sedensky
14. Simon C Johnson

• Curated by eLife

  Evaluation Summary:

  This manuscript reports that Volatile anesthetics VA induce a rapid depletion of circulating ß-HB and the induction of hypoglycemia by VA in neonates, but not in adults. The phenomenon is very interesting and robust, however it has already been described. Whats new here is that through a metabolomics analysis they demonstrate a role of ACC and CPT1 in this phenomenon.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

1. Yunlu Xue
2. Sean K Wang
3. Parimal Rana
4. Emma R West
5. Christin M Hong
6. Helian Feng
7. David M Wu
8. Constance L Cepko

• Curated by eLife

  Evaluation Summary:

  This authors used AAV in mouse retinas to express several candidate genes that they thought might have favorable effects on cone metabolism and therefore make cones more robust to stress caused by genetic deficiencies. Txnip is the most effective at prolonging cones survival and a combo of HK and PFK is the most effective at shortening cone survival. The investigators evaluated effects of specific mutations in Txnip with known biochemical effects. Their general conclusion is that Txnip may be enhancing mitochondrial function and ATP production and it may allow cones to use alternative fuels more effectively. This is an interesting and informative set of findings and it is presented and discussed in the context of what currently is known about retina metabolism and its influences on photoreceptor survival.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.)

Reviewed by eLife