Physiology

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome

1. Ila Mishra
2. Clemens Duerrschmid
3. Zhiqiang Ku
4. Wei Xie
5. Elizabeth Sabath Silva
6. Jennifer Hoffmann
7. Wei Xin
8. Ningyan Zhang
9. Zhiqiang An
10. Atul R. Chopra

• Curated by eLife

  Summary: Mishra et al. present data characterizing the effect of asprosin neutralizing antibodies on the parameters of metabolic syndrome (weight, glucose, lipids, etc). This group were the initial discoverers and characterized asprosin as a hormone that increases blood sugar and stimulates appetite. In their Nature Medicine 2017 article they also present data on a neutralizing antibody. In this follow-up manuscript the group characterizes the impact of neutralizing monoclonal antibodies on metabolic parameters of three mouse models of obesity (DIO, NASH diet and Leptin receptor knockout). The translational focus of the manuscript is potential use of monoclonal antibodies against aprosin as a treatment of metabolic syndrome.

Reviewed by eLife

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

1. Shivani N Mann
2. Niran Hadad
3. Molly Nelson Holte
4. Alicia R Rothman
5. Roshini Sathiaseelan
6. Samim Ali Mondal
7. Martin-Paul Agbaga
8. Archana Unnikrishnan
9. Malayannan Subramaniam
10. John Hawse
11. Derek M Huffman
12. Willard M Freeman
13. Michael B Stout

Reviewed by eLife

Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding

1. Christine Müller
2. Laura M Zidek
3. Sabrina Eichwald
4. Gertrud Kortman
5. Mirjam H Koster
6. Cornelis F Calkhoven

Reviewed by eLife

Effects of Early Life Stress on Bone Homeostasis in Mice and Humans

1. Karin Wuertz-Kozak
2. Martin Roszkowski
3. Elena Cambria
4. Andrea Block
5. Gisela A. Kuhn
6. Thea Abele
7. Wolfgang Hitzl
8. David Drießlein
9. Ralph Müller
10. Michael A. Rapp
11. Isabelle M. Mansuy
12. Eva M. J. Peters
13. Pia M. Wippert

Reviewed by eLife

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

1. Matthew D Keefe
2. Haille E Soderholm
3. Hung-Yu Shih
4. Tamara J Stevenson
5. Kathryn A Glaittli
6. D Miranda Bowles
7. Erika Scholl
8. Samuel Colby
9. Samer Merchant
10. Edward W Hsu
11. Joshua L Bonkowsky

Reviewed by eLife

Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue

1. Katia Aquilano
2. Francesca Sciarretta
3. Riccardo Turchi
4. Bo-Han Li
5. Marco Rosina
6. Veronica Ceci
7. Giulio Guidobaldi
8. Simona Arena
9. Chiara D'Ambrosio
10. Matteo Audano
11. Illari Salvatori
12. Barbara Colella
13. Raffaella Faraonio
14. Concita Panebianco
15. Valerio Pazienza
16. Donatella Caruso
17. Nico Mitro
18. Sabrina Di Bartolomeo
19. Andrea Scaloni
20. Jing-Ya Li
21. Daniele Lettieri-Barbato

Reviewed by Review Commons

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

1. David Cabañero
2. Angela Ramírez-López
3. Eva Drews
4. Anne Schmöle
5. David M Otte
6. Agnieszka Wawrzczak-Bargiela
7. Hector Huerga Encabo
8. Sami Kummer
9. Antonio Ferrer-Montiel
10. Ryszard Przewlocki
11. Andreas Zimmer
12. Rafael Maldonado

Reviewed by eLife

Cancer causes dysfunctional insulin signaling and glucose transport in a muscle‐type‐specific manner

1. Steffen H. Raun
2. Jonas Roland Knudsen
3. Xiuqing Han
4. Thomas E. Jensen
5. Lykke Sylow

Reviewed by PREreview

The energetic effect of hip flexion and retraction in walking at different speeds: a modeling study

1. Jian Jin
2. Dinant Kistemaker
3. Jaap H. van Dieën
4. Andreas Daffertshofer
5. Sjoerd M. Bruijn

Reviewed by PeerJ

Recapitulating human ovarian aging using random walks

1. Joshua Johnson
2. John W. Emerson
3. Sean D. Lawley

Reviewed by PeerJ