Physiology

Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya

1. Samuel Kariuki
2. Zoe A Dyson
3. Cecilia Mbae
4. Ronald Ngetich
5. Susan M Kavai
6. Celestine Wairimu
7. Stephen Anyona
8. Naomi Gitau
9. Robert Sanaya Onsare
10. Beatrice Ongandi
11. Sebastian Duchene
12. Mohamed Ali
13. John David Clemens
14. Kathryn E Holt
15. Gordon Dougan

Reviewed by eLife

The anti-immune dengue subgenomic flaviviral RNA is found in vesicles in mosquito saliva and associated with increased infectivity

1. Shih-Chia Yeh
2. Wei-Lian Tan
3. Avisha Chowdhury
4. Vanessa Chuo
5. R. Manjunatha Kini
6. Julien Pompon
7. Mariano A. Garcia-Blanco

• Curated by eLife

  Evaluation Summary:

  Mosquito saliva can enhance transmission of arboviruses. Here, authors demonstrated that the anti-immune non-coding RNA from Dengue virus, known as the subgenomic flavivirus RNA (sfRNA), is secreted into mosquito saliva within the extracellular vesicles and can facilitate infection of the acceptor human cells when delivered together with infectious virus in mosquito saliva. The study potentially expands our understanding of flavivirus transmission.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

1. Xinle Zou
2. Sri Karthika Shanmugam
3. Scott A Kanner
4. Kevin J Sampson
5. Robert S Kass
6. Henry M Colecraft

• Curated by eLife

  eLife assessment

  This important study provides a substantial advance with a method by which a protein target resistant to therapeutic approaches can be uniquely modulated by a cellular protein kinase ferried by nanobodies to a precise molecular site of recruitment. Evidence for this major claim is compelling, but evidence for some of the minor claims seems incomplete. The work will be of broad interest to cell biologists, cardiovascular researchers, and drug developers.

Reviewed by eLife

Personalized Virus Load Curves of SARS-CoV-2 Infection

1. Thomas Hillen
2. Carlos Contreras
3. Jay M. Newby

Reviewed by ScreenIT

Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19

1. Dylan C. Sarver
2. G. William Wong

Reviewed by ScreenIT

Accounting for body mass effects in the estimation of field metabolic rates from body acceleration

1. Evan E. Byrnes
2. Karissa O. Lear
3. Lauran R. Brewster
4. Nicholas M. Whitney
5. Matthew J. Smukall
6. Nicola J. Armstrong
7. Adrian C. Gleiss

Reviewed by ScreenIT

Quality of Life and Depressive Symptoms Among Peruvian University Students During the COVID-19 Pandemic

1. Joel Figueroa-Quiñones
2. Julio Cjuno
3. Daniel Machay-Pak
4. Miguel Ipanaqué-Zapata

Reviewed by ScreenIT

Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ

1. Subhayan Sur
2. Mousumi Khatun
3. Robert Steele
4. T. Scott Isbell
5. Ranjit Ray
6. Ratna B. Ray

Reviewed by ScreenIT

SARS-COV-2 induced Diarrhea is inflammatory, Ca ²⁺ Dependent and involves activation of calcium activated Cl channels

1. Mark Donowitz
2. Chung-Ming Tse
3. Karol Dokladny
4. Manmeet Rawat
5. Ivy Horwitz
6. Chunyan Ye
7. Alison Kell
8. Ruxian Lin
9. Sun Lee
10. Chenxu Guo
11. Shang Jui Tsai
12. Andrea Cox
13. Stephen Gould
14. Julie In
15. Steven Bradfute
16. Nicholas C. Zachos
17. Olga Kovbasnjuk

Reviewed by ScreenIT

N-Glycosylation Network Construction and Analysis to Modify Glycans on the Spike (S) Glycoprotein of SARS-CoV-2

1. Sridevi Krishnan
2. Giri P. Krishnan

Reviewed by ScreenIT