Pharmacology and Toxicology

  1. Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mice Models

    1. Yingjun Li
    2. Liu Cao
    3. Ge Li
    4. Feng Cong
    5. Yunfeng Li
    6. Jing Sun
    7. Yinzhu Luo
    8. Guijiang Chen
    9. Guanguan Li
    10. Ping Wang
    11. Fan Xing
    12. Yanxi Ji
    13. Jincun Zhao
    14. Yu Zhang
    15. Deyin Guo
    16. Xumu Zhang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. A comparison of Remdesivir versus Au 22 Glutathione 18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

    1. Zhesheng He
    2. Fei Ye
    3. Chunyu Zhang
    4. Jiadong Fan
    5. Zhongying Du
    6. Wencong Zhao
    7. Qing Yuan
    8. Wenchao Niu
    9. Fuping Gao
    10. Bo He
    11. Peng Cao
    12. Lina Zhao
    13. Xuejiao Gao
    14. Xingfa Gao
    15. Bo Sun
    16. Yuhui Dong
    17. Jincun Zhao
    18. Jianxun Qi
    19. Huaidong Jiang
    20. Yong Gong
    21. Wenjie Tan
    22. Xueyun Gao

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Losartan promotes cell survival following SARS-CoV-2 infection in vitro

    1. Reza Nejat
    2. Ahmad Shahir Sadr
    3. Brendan T. Freitas
    4. Jackelyn Crabtree
    5. Scott D. Pegan
    6. Ralph A. Tripp
    7. David J. Najafi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Combined in silico docking and in vitro antiviral testing for drug repurposing identified lurasidone and elbasvir as SARS-CoV-2 and HCoV-OC43 inhibitors

    1. Mario Milani
    2. Manuela Donalisio
    3. Rafaela Milan Bonotto
    4. Edoardo Schneider
    5. Irene Arduino
    6. Francesco Boni
    7. David Lembo
    8. Alessandro Marcello
    9. Eloise Mastrangelo

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. An expedited approach towards the rationale design of non-covalent SARS-CoV-2 main protease inhibitors with in vitro antiviral activity

    1. Naoya Kitamura
    2. Michael Dominic Sacco
    3. Chunlong Ma
    4. Yanmei Hu
    5. Julia Alma Townsend
    6. Xiangzhi Meng
    7. Fushun Zhang
    8. Xiujun Zhang
    9. Adis Kukuljac
    10. Michael Thomas Marty
    11. David Schultz
    12. Sara Cherry
    13. Yan Xiang
    14. Yu Chen
    15. Jun Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

    1. Wei Jiang
    2. Ailing Yang
    3. Jingchuan Ma
    4. Dawei Lv
    5. Mingxian Liu
    6. Liang Xu
    7. Chao Wang
    8. Zhengjin He
    9. Shuo Chen
    10. Jie Zhao
    11. Shishuang Chen
    12. Qi Jiang
    13. Yankai Chu
    14. Lin Shan
    15. Zhaocai Zhou
    16. Yun Zhao
    17. Gang Long
    18. Hai Jiang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray

    1. Krzysztof Pyrć
    2. Aleksandra Milewska
    3. Emilia Barreto Duran
    4. Paweł Botwina
    5. Rui Lopes
    6. Alejandro Arenas-Pinto
    7. Moutaz Badr
    8. Ryan Mellor
    9. Tammy L. Kalber
    10. Delmiro Fernandes-Reyes
    11. Andreas G. Schätzlein
    12. Ijeoma F. Uchegbu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation

    1. Zhijian Xu
    2. Cheng Peng
    3. Yulong Shi
    4. Zhengdan Zhu
    5. Kaijie Mu
    6. Xiaoyu Wang
    7. Weiliang Zhu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Nucleotide Analogues as Inhibitors of Viral Polymerases

    1. Jingyue Ju
    2. Shiv Kumar
    3. Xiaoxu Li
    4. Steffen Jockusch
    5. James J. Russo

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

    1. Ana C. Puhl
    2. Ethan James Fritch
    3. Thomas R. Lane
    4. Longping V. Tse
    5. Boyd L. Yount
    6. Carol Queiroz Sacramento
    7. Tatyana Almeida Tavella
    8. Fabio Trindade Maranhão Costa
    9. Stuart Weston
    10. James Logue
    11. Matthew Frieman
    12. Lakshmanane Premkumar
    13. Kenneth H. Pearce
    14. Brett L. Hurst
    15. Carolina Horta Andrade
    16. James A. Levi
    17. Nicole J. Johnson
    18. Samantha C. Kisthardt
    19. Frank Scholle
    20. Thiago Moreno L. Souza
    21. Nathaniel John Moorman
    22. Ralph S. Baric
    23. Peter Madrid
    24. Sean Ekins

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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