Pharmacology and Toxicology

Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

1. Natasja Barki
2. Daniele Bolognini
3. Ulf Börjesson
4. Laura Jenkins
5. John Riddell
6. David I Hughes
7. Trond Ulven
8. Brian D Hudson
9. Elisabeth Rexen Ulven
10. Niek Dekker
11. Andrew B Tobin
12. Graeme Milligan

• Curated by eLife

  Evaluation Summary:

  In this paper the authors study the Rolle of small chain fatty acids receptors FFA2 and FFA3 in the dorsal root ganglia with the goal to define molecularly a gut to brain axis. They identified MOMBA as a compound that binds to FFA2. This paper presents a powerful screening strategy to identify receptor agonists. The main concerns are the specificity of the model, and the functional purpose of this gut to brain axis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, preLights

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

1. Megan Neary
2. Usman Arshad
3. Lee Tatham
4. Henry Pertinez
5. Helen Box
6. Rajith K.R. Rajoli
7. Anthony Valentijn
8. Joanne Sharp
9. Steve P. Rannard
10. Giancarlo A. Biagini
11. Paul Curley
12. Andrew Owen

Reviewed by ScreenIT

Garcinia kola and garcinoic acid suppress SARS‐CoV ‐2 spike glycoprotein S1 ‐induced hyper‐inflammation in human PBMCs through inhibition of NF‐κB activation

1. Olumayokun A Olajide
2. Victoria U Iwuanyanwu
3. Izabela Lepiarz‐Raba
4. Alaa A Al‐Hindawi
5. Mutalib A Aderogba
6. Hazel L Sharp
7. Robert J Nash

Reviewed by ScreenIT

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

1. Shalini Saxena
2. Kranti Meher
3. Madhuri Rotella
4. Subhramanyam Vangala
5. Satish Chandran
6. Nikhil Malhotra
7. Ratnakar Palakodeti
8. Sreedhara R Voleti
9. Uday Saxena

Reviewed by ScreenIT

In silico and in vitro Demonstration of Homoharrintonine’s Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model

1. Shalini Saxena
2. Kranti Meher
3. Madhuri Rotella
4. Subhramanyam Vangala
5. Satish Chandran
6. Nikhil Malhotra
7. Ratnakar Palakodeti
8. Sreedhara R Voleti
9. Uday Saxena

Reviewed by ScreenIT

Mathematical analysis and topology of SARS-CoV-2, bonding with cells and unbonding

1. Arni S.R. Srinivasa Rao
2. Steven G. Krantz

Reviewed by ScreenIT

ProLung ™- budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation

1. Kameswari S. Konduri
2. Ram Pattisapu
3. Jogi Pattisapu
4. Girija G. Konduri
5. John Zwetchkenbaum
6. Bidhan Roy
7. Monalisa Barman
8. Adria Frazier
9. Brett L. Hurst
10. Nejat Düzgüneş

Reviewed by ScreenIT

Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro

1. Mehmet Altay Unal
2. Ceylan Verda Bitirim
3. Gokce Yagmur Summak
4. Sidar Bereketoglu
5. Inci Cevher Zeytin
6. Omur Besbinar
7. Cansu Gurcan
8. Dunya Aydos
9. Ezgi Goksoy
10. Ebru Kocakaya
11. Zeynep Eran
12. Merve Murat
13. Nil Demir
14. Zeynep Busra Aksoy Ozer
15. Julia Somers
16. Emek Demir
17. Hasan Nazir
18. Sibel Aysil Ozkan
19. Aykut Ozkul
20. Alpay Azap
21. Acelya Yilmazer
22. Kamil Can Akcali

Reviewed by ScreenIT

Discovery of Clioquinol and Analogues as Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, ACE2 and ACE2 - Spike Protein Interaction In Vitro

1. Omonike A. Olaleye
2. Manvir Kaur
3. Collins Onyenaka
4. Tolu Adebusuyi

Reviewed by ScreenIT

Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2

1. Damir Bojadzic
2. Oscar Alcazar
3. Jinshui Chen
4. Sung-Ting Chuang
5. Jose M. Condor Capcha
6. Lina A. Shehadeh
7. Peter Buchwald

Reviewed by ScreenIT