Pharmacology and Toxicology

  1. Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

    1. M Neary
    2. H Box
    3. J Sharp
    4. L Tatham
    5. P Curley
    6. J Herriott
    7. E Kijak
    8. U Arshad
    9. JJ Hobson
    10. RKR Rajoli
    11. H Pertinez
    12. A Valentijn
    13. K Dhaliwal
    14. F McCaughan
    15. SP Rannard
    16. A Kipar
    17. JP Stewart
    18. A Owen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs

    1. Noa Madar-Balakirski
    2. Amir Rosner
    3. Sharon Melamed
    4. Boaz Politi
    5. Michal Steiner
    6. Hadas Tamir
    7. Yfat Yahalom-Ronen
    8. Elad Bar-David
    9. Amir Ben-Shmuel
    10. Assa Sittner
    11. Itai Glinert
    12. Shay Weiss
    13. Erez Bar-Haim
    14. Hila Cohen
    15. Uri Elia
    16. Hagit Achdout
    17. Noam Erez
    18. Shahar Rotem
    19. Shlomi Lazar
    20. Abraham Nyska
    21. Shmuel Yitzhaki
    22. Adi Beth-Din
    23. Haim Levy
    24. Nir Paran
    25. Tomer Israely
    26. Hadar Marcus

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening

    1. Kirill Gorshkov
    2. Desarey Morales Vasquez
    3. Kevin Chiem
    4. Chengjin Ye
    5. Bruce Nguyen Tran
    6. Juan Carlos de la Torre
    7. Thomas Moran
    8. Catherine Z. Chen
    9. Luis Martinez-Sobrido
    10. Wei Zheng

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm

    1. Shalini Saxena
    2. Kranti Meher
    3. Madhuri Rotella
    4. Subhramanyam Vangala
    5. Satish Chandran
    6. Nikhil Malhotra
    7. Ratnakar Palakodeti
    8. Sreedhara R Voleti
    9. Uday Saxena

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**

    1. Xinyu R. Ma
    2. Yugendar R. Alugubelli
    3. Yuying Ma
    4. Erol C. Vatansever
    5. Danielle A. Scott
    6. Yuchen Qiao
    7. Ge Yu
    8. Shiqing Xu
    9. Wenshe Ray Liu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection

    1. Ailyn C. Ramón
    2. George V. Pérez
    3. Evelin Caballero
    4. Mauro Rosales
    5. Daylén Aguilar
    6. Dania Vázquez-Blomquist
    7. Yassel Ramos
    8. Arielis Rodríguez-Ulloa
    9. Viviana Falcón
    10. María Pilar Rodríguez-Moltó
    11. Ke Yang
    12. Yasser Perera
    13. Silvio E. Perea

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

    1. Hung Caohuy
    2. Ofer Eidelman
    3. Tinghua Chen
    4. Shufeng Liu
    5. Qingfeng Yang
    6. Alakesh Bera
    7. Nathan I. Walton
    8. Tony T. Wang
    9. Harvey B. Pollard

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

    1. Natasja Barki
    2. Daniele Bolognini
    3. Ulf Börjesson
    4. Laura Jenkins
    5. John Riddell
    6. David I Hughes
    7. Trond Ulven
    8. Brian D Hudson
    9. Elisabeth Rexen Ulven
    10. Niek Dekker
    11. Andrew B Tobin
    12. Graeme Milligan

    • Curated by eLife

      Evaluation Summary:

      In this paper the authors study the Rolle of small chain fatty acids receptors FFA2 and FFA3 in the dorsal root ganglia with the goal to define molecularly a gut to brain axis. They identified MOMBA as a compound that binds to FFA2. This paper presents a powerful screening strategy to identify receptor agonists. The main concerns are the specificity of the model, and the functional purpose of this gut to brain axis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, preLights

    5 evaluationsAppears in 2 listsLatest version Latest activity

  9. Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

    1. Megan Neary
    2. Usman Arshad
    3. Lee Tatham
    4. Henry Pertinez
    5. Helen Box
    6. Rajith K.R. Rajoli
    7. Anthony Valentijn
    8. Joanne Sharp
    9. Steve P. Rannard
    10. Giancarlo A. Biagini
    11. Paul Curley
    12. Andrew Owen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Garcinia kola and garcinoic acid suppress SARS‐CoV ‐2 spike glycoprotein S1 ‐induced hyper‐inflammation in human PBMCs through inhibition of NF‐κB activation

    1. Olumayokun A Olajide
    2. Victoria U Iwuanyanwu
    3. Izabela Lepiarz‐Raba
    4. Alaa A Al‐Hindawi
    5. Mutalib A Aderogba
    6. Hazel L Sharp
    7. Robert J Nash

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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