Pharmacology and Toxicology

Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm

1. Shalini Saxena
2. Kranti Meher
3. Madhuri Rotella
4. Subhramanyam Vangala
5. Satish Chandran
6. Nikhil Malhotra
7. Ratnakar Palakodeti
8. Sreedhara R Voleti
9. Uday Saxena

Reviewed by ScreenIT

MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**

1. Xinyu R. Ma
2. Yugendar R. Alugubelli
3. Yuying Ma
4. Erol C. Vatansever
5. Danielle A. Scott
6. Yuchen Qiao
7. Ge Yu
8. Shiqing Xu
9. Wenshe Ray Liu

Reviewed by ScreenIT

Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection

1. Ailyn C. Ramón
2. George V. Pérez
3. Evelin Caballero
4. Mauro Rosales
5. Daylén Aguilar
6. Dania Vázquez-Blomquist
7. Yassel Ramos
8. Arielis Rodríguez-Ulloa
9. Viviana Falcón
10. María Pilar Rodríguez-Moltó
11. Ke Yang
12. Yasser Perera
13. Silvio E. Perea

Reviewed by ScreenIT

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

1. Hung Caohuy
2. Ofer Eidelman
3. Tinghua Chen
4. Shufeng Liu
5. Qingfeng Yang
6. Alakesh Bera
7. Nathan I. Walton
8. Tony T. Wang
9. Harvey B. Pollard

Reviewed by ScreenIT

Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

1. Natasja Barki
2. Daniele Bolognini
3. Ulf Börjesson
4. Laura Jenkins
5. John Riddell
6. David I Hughes
7. Trond Ulven
8. Brian D Hudson
9. Elisabeth Rexen Ulven
10. Niek Dekker
11. Andrew B Tobin
12. Graeme Milligan

• Curated by eLife

  Evaluation Summary:

  In this paper the authors study the Rolle of small chain fatty acids receptors FFA2 and FFA3 in the dorsal root ganglia with the goal to define molecularly a gut to brain axis. They identified MOMBA as a compound that binds to FFA2. This paper presents a powerful screening strategy to identify receptor agonists. The main concerns are the specificity of the model, and the functional purpose of this gut to brain axis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, preLights

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

1. Megan Neary
2. Usman Arshad
3. Lee Tatham
4. Henry Pertinez
5. Helen Box
6. Rajith K.R. Rajoli
7. Anthony Valentijn
8. Joanne Sharp
9. Steve P. Rannard
10. Giancarlo A. Biagini
11. Paul Curley
12. Andrew Owen

Reviewed by ScreenIT

Garcinia kola and garcinoic acid suppress SARS‐CoV ‐2 spike glycoprotein S1 ‐induced hyper‐inflammation in human PBMCs through inhibition of NF‐κB activation

1. Olumayokun A Olajide
2. Victoria U Iwuanyanwu
3. Izabela Lepiarz‐Raba
4. Alaa A Al‐Hindawi
5. Mutalib A Aderogba
6. Hazel L Sharp
7. Robert J Nash

Reviewed by ScreenIT

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

1. Shalini Saxena
2. Kranti Meher
3. Madhuri Rotella
4. Subhramanyam Vangala
5. Satish Chandran
6. Nikhil Malhotra
7. Ratnakar Palakodeti
8. Sreedhara R Voleti
9. Uday Saxena

Reviewed by ScreenIT

In silico and in vitro Demonstration of Homoharrintonine’s Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model

1. Shalini Saxena
2. Kranti Meher
3. Madhuri Rotella
4. Subhramanyam Vangala
5. Satish Chandran
6. Nikhil Malhotra
7. Ratnakar Palakodeti
8. Sreedhara R Voleti
9. Uday Saxena

Reviewed by ScreenIT

Mathematical analysis and topology of SARS-CoV-2, bonding with cells and unbonding

1. Arni S.R. Srinivasa Rao
2. Steven G. Krantz

Reviewed by ScreenIT