Pharmacology and Toxicology

Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic

1. Yuen Ler Chow
2. Shantanu Singh
3. Anne E. Carpenter
4. Gregory P. Way

Reviewed by Review Commons

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

1. Marcia A Munoz
2. Emma K Fletcher
3. Oliver P Skinner
4. Julie Jurczyluk
5. Esther Kristianto
6. Mark P Hodson
7. Shuting Sun
8. Frank H Ebetino
9. David R Croucher
10. Philip M Hansbro
11. Jacqueline R Center
12. Michael J Rogers

• Curated by eLife

  Evaluation Summary:

  The manuscript by Munoz et al describes the effect of the bisphosphonate zoledronic acid on tissue-resident macrophages. For this, the investigators used both a fluorescent bisphosphonate derivative and an unmodified zoledronic acid, in combination with macrophage populations isolated from different tissues. Based on the pattern of cytokines released by macrophages in the presence of zoledronic acid, the authors conclude that administration of bisphosphonates could, in addition to preventing bone loss, boost immune responses and lessen the consequences of respiratory infections.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

"Repurposed Nystatin to Inhibit SARS-Cov-2 and Mutants in the GI Tract"

1. Eszter Virág

Reviewed by ScreenIT

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

1. Ittipat Meewan
2. Jacob Kattoula
3. Julius Y. Kattoula
4. Danielle Skinner
5. Pavla Fajtová
6. Miriam A. Giardini
7. Brendon Woodworth
8. James H. McKerrow
9. Jair Lage de Siqueira-Neto
10. Anthony J. O’Donoghue
11. Ruben Abagyan

Reviewed by ScreenIT

Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice

1. Steven D. Brooks
2. Rachel L. Smith
3. Aline S. Moreira
4. Hans C. Ackerman

Reviewed by ScreenIT

AUG-3387, a Human-Derived Monoclonal Antibody Neutralizes SARS-CoV-2 Variants and Reduces Viral Load from Therapeutic Treatment of Hamsters In Vivo

1. Christopher J. Emig
2. Marco A. Mena
3. Steven J. Henry
4. Adela Vitug
5. Christian John Ventura
6. Douglas Fox
7. Xammy Huu Nguyenla
8. Haiyue Xu
9. Chaeho Moon
10. Sawittree Sahakijjpijarn
11. Philip J. Kuehl
12. David Revelli
13. Zengrong Cui
14. Robert O. Williams
15. Dale J. Christensen

Reviewed by ScreenIT

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

1. Miao Xu
2. Manisha Pradhan
3. Kirill Gorshkov
4. Jennifer D. Petersen
5. Min Shen
6. Hui Guo
7. Wei Zhu
8. Carleen Klumpp-Thomas
9. Sam Michael
10. Misha Itkin
11. Zina Itkin
12. Marco R. Straus
13. Joshua Zimmerberg
14. Wei Zheng
15. Gary R. Whittaker
16. Catherine Z. Chen

Reviewed by ScreenIT

Pyronaridine Protects Against SARS-CoV-2 in Mouse

1. Ana C. Puhl
2. Giovanni F. Gomes
3. Samara Damasceno
4. Andre S. Godoy
5. Gabriela D. Noske
6. Aline M. Nakamura
7. Victor O. Gawriljuk
8. Rafaela S. Fernandes
9. Natalia Monakhova
10. Olga Riabova
11. Thomas R. Lane
12. Vadim Makarov
13. Flavio P. Veras
14. Sabrina S. Batah
15. Alexandre T. Fabro
16. Glaucius Oliva
17. Fernando Q. Cunha
18. José C. Alves-Filho
19. Thiago M. Cunha
20. Sean Ekins

Reviewed by ScreenIT

Development of a novel, pan-variant aerosol intervention for COVID-19

1. Robert H. Shoemaker
2. Reynold A. Panettieri
3. Steven K. Libutti
4. Howard S. Hochster
5. Norman R. Watts
6. Paul T. Wingfield
7. Philipp Starkl
8. Lisabeth Pimenov
9. Riem Gawish
10. Anastasiya Hladik
11. Sylvia Knapp
12. Daniel Boring
13. Jonathan M. White
14. Quentin Lawrence
15. Jeremy Boone
16. Jason D. Marshall
17. Rebecca L. Matthews
18. Brian D. Cholewa
19. Jeffrey W. Richig
20. Ben T. Chen
21. David L. McCormick
22. Romana Gugensberger
23. Sonja Höller
24. Josef M. Penninger
25. Gerald Wirnsberger

Reviewed by ScreenIT

In silico, in vitro screening of plant extracts for anti-SARS-CoV-2 activity and evaluation of their acute and sub-acute toxicity

1. Damle Latha
2. Damle Hrishikesh
3. Ganju Shiban
4. C Chandrashekar
5. BR Bharath

Reviewed by ScreenIT