Pharmacology and Toxicology

Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

1. Hai Qiu
2. Xia Yue
3. Yuebing Huang
4. Ziling Meng
5. Jiahong Wang
6. Dongfang Qiao

• Curated by eLife

  eLife Assessment

  The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns about data interpretation, and the current evidence is incomplete, requiring further experimental validation.

Reviewed by eLife

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2

1. Mohammad M. Ghahremanpour
2. Julian Tirado-Rives
3. Maya Deshmukh
4. Joseph A. Ippolito
5. Chun-Hui Zhang
6. Israel Cabeza de Vaca
7. Maria-Elena Liosi
8. Karen S. Anderson
9. William L. Jorgensen

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Snake venom metalloproteinases are predominantly responsible for the cytotoxic effects of certain African viper venoms

1. Keirah E. Bartlett
2. Adam Westhorpe
3. Mark C. Wilkinson
4. Nicholas R. Casewell

Reviewed by preLights

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

1. Diana Angelica Aguilar Ayala
2. Marie Sylvianne Rabodoarivelo
3. Maxime R. Eveque-Mourroux
4. Albin AM Leding
5. Lindsay Sonnekalb
6. Ana Picó Marco
7. Nicolas Willand
8. Natalya Serbina
9. Ulrika SH Simonsson
10. Ainhoa Lucía
11. Santiago Ramón-García
12. ERA4TB consortium

Reviewed by preLights