1. SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

    This article has 12 authors:
    1. Dandan Wu
    2. Chi Yang
    3. Yanfang Yao
    4. Dongmei Ma
    5. Hong Lin
    6. Ling Hao
    7. Wenwen Xin
    8. Kangfu Ye
    9. Minghui Sun
    10. Yule Hu
    11. Yanling Yang
    12. Zhenhong Zhuang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this useful study, the authors investigate the regulatory mechanisms related to toxin production and pathogenicity in Aspergillus flavus. Their observations indicate that the SntB protein regulates morphogenesis, aflatoxin biosynthesis, and the oxidative stress response. The data supporting the conclusions are compelling and contribute significantly the advancing the understanding of SntB function.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  2. Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

    This article has 11 authors:
    1. Giada Lavigna
    2. Anna Grasso
    3. Chiara Pasini
    4. Valentina Grande
    5. Laura Mignogna
    6. Elena Restelli
    7. Antonio Masone
    8. Claudia Fracasso
    9. Jacopo Lucchetti
    10. Marco Gobbi
    11. Roberto Chiesa

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

    This article has 14 authors:
    1. Richard T Eastman
    2. Radda Rusinova
    3. Karl F Herold
    4. Xi-Ping Huang
    5. Patricia Dranchak
    6. Ty C Voss
    7. Sandeep Rana
    8. Jonathan H Shrimp
    9. Alex D White
    10. Hugh C Hemmings
    11. Bryan L Roth
    12. James Inglese
    13. Olaf S Andersen
    14. Jayme L Dahlin

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  4. Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction

    This article has 12 authors:
    1. Soo-Yeon Hwang
    2. Kyung-Hwa Jeon
    3. Hwa-Jong Lee
    4. Inhye Moon
    5. Sehyun Jung
    6. Seul-Ah Kim
    7. Hyunji Jo
    8. Seojeong Park
    9. Misun Ahn
    10. Soo-Yeon Kwak
    11. Younghwa Na
    12. Youngjoo Kwon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work characterized a new set of small molecules targeting the interaction between ELF3-MED23, with one of the reported compounds representing a promising novel therapeutic strategy, The evidence supporting the conclusions is solid, although including characterization with breast and lung cancer cell models would strengthen the study. This article will be of interest to medical and cell biologists working on cancer and, particularly, on HER2-overexpression cancers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

    This article has 9 authors:
    1. Yalan Jiang
    2. Pingping He
    3. Ke Sheng
    4. Yongmiao Peng
    5. Huilan Wu
    6. Songwei Qian
    7. Weiping Ji
    8. Xiaoling Guo
    9. Xiaoou Shan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study partially succeeds in providing evidence to support the therapeutic potential of the plant-derived compound eugenol for ameliorating symptoms associated with Type 1 Diabetes, identifying Nuclear factor E2 - related factor (Nrf2) as a mediator of the effects induced by eugenol. Although the study provides some interesting data, the evidence for the proposed mechanism is currently incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Visualization of endogenous G proteins on endosomes and other organelles

    This article has 4 authors:
    1. Wonjo Jang
    2. Kanishka Senarath
    3. Sumin Lu
    4. Nevin A. Lambert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study investigates the intracellular localization patterns of G proteins involved in GPCR signaling, presenting convincing evidence for their preference for plasma and lysosomal membranes over endosomal, endoplasmic reticulum, and Golgi membranes. This discovery has significant implications for understanding GPCR action and signaling from intracellular locations. This research will interest cell biologists studying protein trafficking and pharmacologists exploring localized signaling phenomena.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

    This article has 14 authors:
    1. Ting Zhang
    2. Alisa Ambrodji
    3. Huixing Huang
    4. Kelly J Bouchonville
    5. Amy S Etheridge
    6. Remington E Schmidt
    7. Brianna M Bembenek
    8. Zoey B Temesgen
    9. Zhiquan Wang
    10. Federico Innocenti
    11. Deborah Stroka
    12. Robert B Diasio
    13. Carlo R Largiadèr
    14. Steven M Offer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript presents valuable findings on the identification of epigenetically mediated control for the recognition of dihydropyrimidine dehydrogenase (DPYD) gene expression that is linked with cancer treatment resistance using 5-fluorouracil. The evidence is compelling, supported by data from patient-derived specimens and direct assessment of 5-fluorouracil sensitivity, which provides confidence in the proposed mechanisms. The model is additionally supported by genome data from a population with high "compromised allele frequency". This work will interest those studying drug resistance in cancer therapy.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

    This article has 8 authors:
    1. Xiaoning wang
    2. Jinxiang Zhao
    3. Jiehuan Xu
    4. Bowen Li
    5. Xia Liu
    6. Gangcai Xie
    7. Xuchu Duan
    8. Dong Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript addresses an important subject regarding the effects of the consumption of artificially sweetened beverages. The authors used zebrafish embryos treated with high concentrations of monosaccharides and observed hyperangiogenic characteristics similar to those seen in proliferative diabetic retinopathy. Their findings suggest that caloric and noncaloric monosaccharides induce excessive angiogenesis via the foxo1a-Marcksl1a pathway, but the evidence is currently incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

    This article has 17 authors:
    1. Ling Zhou
    2. Chengyang Ni
    3. Ruixue Liao
    4. Xiaoqin Tang
    5. Taian Yi
    6. Mei Ran
    7. Miao Huang
    8. Rui Liao
    9. Xiaogang Zhou
    10. Dalian Qin
    11. Long Wang
    12. Feihong Huang
    13. Xiang Xie
    14. Ying Wan
    15. Jiesi Luo
    16. Yiwei Wang
    17. Jianming Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a rather valuable finding that vilazodone can restore the normal platelet level through regulating 5-HT1A receptor. The evidence supporting the claims of the authors is solid, although inclusion of more cell lines and more detailed analysis of the results would have strengthened the study. The work will be of interest to scientists working in the field of thrombocytopenia.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

    This article has 14 authors:
    1. Changlin Du
    2. Chuanting Xu
    3. Pengcheng Jia
    4. Na Cai
    5. Zhenming Zhang
    6. Wenna Meng
    7. Lu Chen
    8. Zhongnan Zhou
    9. Qi Wang
    10. Rui Feng
    11. Jun Li
    12. Xiaoming Meng
    13. Cheng Huang
    14. Taotao Ma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper is of interest to a broad audience of cell biologists, and researchers who work in cell death and the role of NETosis in the pathogenesis of chronic diseases. This study presents valuable new insights to support NETosis plays an important role in the development of aristolochic acid nephropathy (AAN). A series of compelling experiments using in vivo and in vitro model supported that AAN induced NET formation via IL-19-IL20-beta receptor can induce inflammation and cell death. This new knowledge of the interaction between kidney cells and neutrophils could have clinical implications in the treatment of AAN.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity