Pathology

Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

1. Konrad H Stopsack
2. Svitlana Tyekucheva
3. Molin Wang
4. Travis A Gerke
5. J Bailey Vaselkiv
6. Kathryn L Penney
7. Philip W Kantoff
8. Stephen P Finn
9. Michelangelo Fiorentino
10. Massimo Loda
11. Tamara L Lotan
12. Giovanni Parmigiani
13. Lorelei A Mucci

• Curated by eLife

  Evaluation Summary:

  Tissue microarrays (TMA) have become a mainstay in clinical and basic research, for both discovery and validation of biomarkers. This manuscript provides relevant methodologic considerations for cancer researchers investigating tissue-biomarkers using TMAs. A comprehensive investigation was conducted using a combination of analytic approaches using empirical data and simulated data to support key findings and conclusions. The authors approach the possible sampling variation in a thoughtful way, not only quantifying the issue systematically, but working towards a solution.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 wildlife surveillance in Ontario and Québec

1. JE Greenhorn
2. JD Kotwa
3. J Bowman
4. L Bruce
5. T Buchanan
6. PA Buck
7. CM Davy
8. A Dibernardo
9. L Flockhart
10. M Gagnier
11. A Hou
12. CM Jardine
13. S Lair
14. LR Lindsay
15. A Massé
16. PK Muchaal
17. LA Nituch
18. A Sotto
19. B Stevens
20. L Yip
21. S Mubareka

Reviewed by ScreenIT

Acute SARS-CoV-2 infection in pregnancy is associated with placental ACE-2 shedding

1. Elizabeth S. Taglauer
2. Elisha M. Wachman
3. Lillian Juttukonda
4. Timothy Klouda
5. Jiwon Kim
6. Qiong Wang
7. Asuka Ishiyama
8. David J. Hackam
9. Ke Yuan
10. Hongpeng Jia

Reviewed by ScreenIT

A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

1. Junyu Chen
2. Pui Wang
3. Lunzhi Yuan
4. Liang Zhang
5. Limin Zhang
6. Hui Zhao
7. Congjie Chen
8. Xijing Wang
9. Jinle Han
10. Yaode Chen
11. Jizong Jia
12. Zhen Lu
13. Junping Hong
14. Zicen Lu
15. Qian Wang
16. Rirong Chen
17. Ruoyao Qi
18. Jian Ma
19. Min Zhou
20. Huan Yu
21. Chunlan Zhuang
22. Xiaohui Liu
23. Qiangyuan Han
24. Guosong Wang
25. Yingying Su
26. Quan Yuan
27. Tong Cheng
28. Ting Wu
29. Xiangzhong Ye
30. Tianying Zhang
31. Changgui Li
32. Jun Zhang
33. Huachen Zhu
34. Yixin Chen
35. Honglin Chen
36. Ningshao Xia

Reviewed by ScreenIT

Visceral Fat Inflammation and Fat Embolism are associated with Lung’s Lipidic Hyaline Membranes in COVID-19 patients

1. Georgia Colleluori
2. Laura Graciotti
3. Mauro Pesaresi
4. Angelica Di Vincenzo
5. Jessica Perugini
6. Eleonora Di Mercurio
7. Sara Caucci
8. Patrizia Bagnarelli
9. Cristina M. Zingaretti
10. Enzo Nisoli
11. Stefano Menzo
12. Adriano Tagliabracci
13. Annie Ladoux
14. Christian Dani
15. Antonio Giordano
16. Saverio Cinti

Reviewed by ScreenIT

Evaluation of Viral Loads in Patients With SARS-CoV-2 Delta Variant Infection: Higher Loads Do Not Translate Into Different Testing Scenarios

1. Juan Luis Gomez Marti
2. Ashley Mays
3. Melissa McCullough
4. Alan Wells
5. Tung Phan

Reviewed by ScreenIT

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

1. David Legouis
2. Anna Rinaldi
3. Daniele Malpetti
4. Gregoire Arnoux
5. Thomas Verissimo
6. Anna Faivre
7. Francesca Mangili
8. Andrea Rinaldi
9. Lorenzo Ruinelli
10. Jerome Pugin
11. Solange Moll
12. Luca Clivio
13. Marco Bolis
14. Sophie de Seigneux
15. Laura Azzimonti
16. Pietro E. Cippà

Reviewed by ScreenIT

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

1. Marius Reichardt
2. Patrick Moller Jensen
3. Vedrana Andersen Dahl
4. Anders Bjorholm Dahl
5. Maximilian Ackermann
6. Harshit Shah
7. Florian Länger
8. Christopher Werlein
9. Mark P Kuehnel
10. Danny Jonigk
11. Tim Salditt

• Curated by eLife

  Evaluation Summary:

  This manuscript aims to characterize cardiac tissues from patients who developed Covid-19. The authors studied pathological and normal tissues using microtomography scans performed at different resolution scales. Starting on the reconstructed volumes, special automatic analytical procedures were developed to extract some quantitative structural parameters about the samples themselves. This characterization method was used previously in the study of murine heart models. The main outcome of the research is that there are some well defined characteristics found in tissues of COVID patients that are not revealed in other pathological and normal samples.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, ScreenIT

Sex differences in cardio-pulmonary pathology of SARS-CoV2 infected and Trypanosoma cruzi co-infected mice

1. Dhanya Dhanyalayam
2. Kezia Lizardo
3. Neelam Oswal
4. Hariprasad Thangavel
5. Enriko Dolgov
6. David S. Perlin
7. Jyothi F. Nagajyothi

Reviewed by ScreenIT

Digital spatial profiling of collapsing glomerulopathy

1. Kelly D. Smith
2. David K. Prince
3. Kammi J. Henriksen
4. Roberto F. Nicosia
5. Charles E. Alpers
6. Shreeram Akilesh

Reviewed by ScreenIT