Orthopedics

PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

1. Pengbo Chen
2. Bo Li
3. Zeyu Lu
4. Qingyin Xu
5. Huoliang Zheng
6. Shengdan Jiang
7. Leisheng Jiang
8. Xinfeng Zheng

• Curated by eLife

  eLife assessment

  In this valuable study, the authors aimed to identify and characterize intrinsic factors that govern the aging process of bone marrow mesenchymal stromal cells (BMSCs), which are believed to be related to osteoporosis. The authors conclude that PCBP2 is an intrinsic aging factor, the decrease of its expression during aging results in cell proliferation activity decrease and cell senescence. The study provides convincing evidence in support of its conclusions.

Reviewed by eLife

Comparable in vivo joint kinematics between self-reported stable and unstable knees after TKA can be explained by muscular adaptation strategies: A retrospective observational study

1. Longfeng Rao
2. Nils Horn
3. Nadja Meister
4. Stefan Preiss
5. William R Taylor
6. Alessandro Santuz
7. Pascal Schütz

• Curated by eLife

  eLife assessment

  This manuscript provides valuable data gathered using a new video fluoroscopy method by which movements of artificial joints can be visualized in real time. These solid data add to the understanding of the links between symptoms of unstable joints after total knee replacement and actual joint instability. The paper should be of interest to those who study biomechanics after total joint replacement.

Reviewed by eLife

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

1. Xiang Li
2. Guangjun Jiao
3. Yunzhen Chen

• Curated by eLife

  eLife assessment

  The study presents a useful finding on a potential link between two common public health issues, namely HPV infection and osteoporosis. The evidence supporting the claims of the authors is incomplete as a more robust statistical methodology would have strengthened the study. The work will be of interest to epidemiologists working on associations of infectious diseases with other health issues.

Reviewed by eLife

Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

1. Weili Fu
2. Sijie Chen
3. Runze Yang
4. Chen Li
5. Haoxiang Gao
6. Jian Li
7. Xuegong Zhang

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to researchers studying meniscus homeostasis and knee osteoarthritis. It uncovers distinct subtypes of cell populations in inner and outer part of human meniscus using single-cell RNA sequencing. In particular, this work further identifies how alterations in meniscal cell populations may contribute to inflammation and osteoarthritis and thus serves as a resource paper for the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The impact of COVID-19 on acute Trauma and Orthopaedic referrals and surgery in the UK: the ‘golden peak weeks’ of the first national multi-centre observational study: The COVid-Emergency Related Trauma and orthopaedics (COVERT) Collaborative

1. Kapil Sugand
2. COVERT Collaborative

Reviewed by ScreenIT

Bioaerosols in orthopedic surgical procedures and implications for clinical practice in the times of COVID-19: A systematic review and meta-analysis

1. Siddhartha Sharma
2. Rakesh John
3. Sandeep Patel
4. Deepak Neradi
5. Kamal Kishore
6. Mandeep S. Dhillon

Reviewed by ScreenIT

COVID-19 and orthopaedic surgery in a large trauma centre in India

1. Kannan Karuppiah Kumar
2. Thomas Chandy
3. MN Kumar
4. Muniramaiah Ravishankar
5. Chetan Rai
6. A Chetan
7. Vijay Girish
8. Krishna Kumar
9. Praveen S Battepati
10. Deepak G Shivarathre
11. Harish Puranik
12. Noel Naleen Kumar
13. Harshvardhan
14. NK Deepu
15. Mayur Shetty

Reviewed by ScreenIT