Oncology

Use of antihypertensive drugs and breast cancer risk: a two-sample Mendelian randomization study

1. Guoqiao Zheng
2. Subhayan Chattopadhyay
3. Jan Sundquist
4. Kristina Sundquist
5. Jianguang Ji

• Curated by eLife

  Evaluation Summary:

  Results from observational studies examining an association between the antihypertensive drugs and the risk of breast cancer reported inconsistent findings. This study uses a two-sample Mendelian randomization approach (MR), which overcomes the limitation of observational studies by using genetic variants as a proxy for modifiable exposures, to investigate the relationship between the use of antihypertensive medication and breast cancer risk. Using publicly available data and including a comprehensive assessment of antihypertensive drugs, the authors identified two SNPs that were associated with breast cancer risk. While the findings suggest that antihypertensive medication use may be associated with breast cancer risk, there are some methodological issues that need to be addressed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Immune Profiling Uncovers Memory T-Cell Responses with a Th17 Signature in Cancer Patients with Previous SARS-CoV-2 Infection Followed by mRNA Vaccination

1. Miriam Echaide
2. Ibone Labiano
3. Marina Delgado
4. Angela Fernández de Lascoiti
5. Patricia Ochoa
6. Maider Garnica
7. Pablo Ramos
8. Luisa Chocarro
9. Leticia Fernández
10. Hugo Arasanz
11. Ana Bocanegra
12. Ester Blanco
13. Sergio Piñeiro-Hermida
14. Pilar Morente
15. Ruth Vera
16. Maria Alsina
17. David Escors
18. Grazyna Kochan

Reviewed by ScreenIT

Is cancer significant comorbid condition in COVID 19 infected patients? -A retrospective analysis experienced in a tertiary care center in Eastern India

1. Kalyan K. Mukherjee
2. Aniruddha Dam
3. Deepa Chakrabarti
4. Debasish Jatu
5. Saubhik Sengupta
6. Rita Dutta
7. Suparna Majumdar
8. Shyam Sundar Mandal
9. Biswarup Basu
10. Pratiti Bhattacharjee
11. Dattatreya Mukherjee
12. Sankar Sengupta
13. Jayanta Chakrabarti

Reviewed by ScreenIT

Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

1. Jingsong Zhang
2. Jessica Cunningham
3. Joel Brown
4. Robert Gatenby

• Curated by eLife

  Evaluation Summary:

  Zhang et al use evolution-guided mathematical models to guide the timing and dosing of arbiterone treatment in castrate-resistant prostate cancer. While the sample size is limited, the implications of the study outcome are broad and compelling, and the paper importantly highlights the transformative potential of deeply interdisciplinary research.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Characteristics of patients with hematologic malignancies without seroconversion post-COVID-19 third vaccine dosing

1. Sigrun Hallmeyer
2. Michael A Thompson
3. Veronica Fitzpatrick
4. Yunqi Liao
5. Michael P Mullane
6. Stephen C Medlin
7. Kenneth Copeland
8. James L Weese

Reviewed by ScreenIT

Production of anti-spike antibodies in response to COVID vaccine in lymphoma patients

1. Alexandra Della Pia
2. Gee Youn (Geeny) Kim
3. Andrew Ip
4. Jaeil Ahn
5. Yanzhi Liu
6. Simone Kats
7. Michael Koropsak
8. Brittany Lukasik
9. Anamta Contractor
10. Krushna Amin
11. Lakshmi Ayyagari
12. Charles Zhao
13. Amolika Gupta
14. Mark Batistick
15. Lori A. Leslie
16. Andre Goy
17. Tatyana Feldman

Reviewed by ScreenIT

The Outcome of Gynecologic Cancer Patients With Covid-19 Infection: A Systematic Review And Meta-Analysis

1. I Gde Sastra Winata
2. Januar Simatupang
3. Arie A Polim
4. Yakob Togar
5. Advenny Elisabeth Tondang

Reviewed by ScreenIT

Scottish COVID CAncer iMmunity Prevalence (SCCAMP) - a longitudinal study of patients with cancer receiving active anti-cancer treatment during the COVID-19 pandemic

1. Karin Purshouse
2. John P Thomson
3. Mahéva Vallet
4. Lorna Alexander
5. Isaac Bonisteel
6. Maree Brennan
7. David A Cameron
8. Jonine D Figueroa
9. Elizabeth Furrie
10. Pamela Haig
11. Mattea Heck
12. Hugh McCaughan
13. Paul Mitchell
14. Heather McVicars
15. Lorraine Primrose
16. Kate Templeton
17. Natalie Wilson
18. Peter S Hall

Reviewed by ScreenIT

SARS-CoV-2 Antibody Seroprevalence in Patients With Cancer on Systemic Antineoplastic Treatment in the First Wave of the COVID-19 Pandemic in Portugal

1. Gonçalo Fernandes
2. Paulo Paixão
3. Laura Brum
4. Teresa Padrão
5. Jorge Correia
6. Joana Albuquerque
7. Catarina Pulido
8. Mónica Nave
9. Teresa Timóteo
10. Tânia Rodrigues
11. Filipe Costa
12. José L Passos-Coelho

Reviewed by ScreenIT

mRNA-COVID19 Vaccination Can Be Considered Safe and Tolerable for Frail Patients

1. Maria Teresa Lupo-Stanghellini
2. Serena Di Cosimo
3. Massimo Costantini
4. Sara Monti
5. Renato Mantegazza
6. Alberto Mantovani
7. Carlo Salvarani
8. Pier Luigi Zinzani
9. Matilde Inglese
10. Fabio Ciceri
11. Giovanni Apolone
12. Gennaro Ciliberto
13. Fausto Baldanti
14. Aldo Morrone
15. Valentina Sinno
16. Franco Locatelli
17. Stefania Notari
18. Elena Turola
19. Diana Giannarelli
20. Nicola Silvestris

Reviewed by ScreenIT