Oncology

Systematic investigations of COVID-19 in 283 cancer patients

1. Jie Wang
2. Qibin Song
3. Yuan Chen
4. Zhijie Wang
5. Qian Chu
6. Hongyun Gong
7. Shangli Cai
8. Xiaorong Dong
9. Bin Xu
10. Weidong Hu
11. Qun Wang
12. Linjun Li
13. Jiyuan Yang
14. Zhibin Xie
15. Zhiguo Luo
16. Jing Liu
17. Xiuli Luo
18. Jie Ren
19. Zhiguo Rao
20. Xinhua Xu
21. Dongfeng Pan
22. Zuowei Hu
23. Gang Feng
24. Chiding Hu
25. Liqiong Luo
26. Hongda Lu
27. Ruizhi Ran
28. Jun Jin
29. Yanhua Xu
30. Yong Yang
31. Zhihong Zhang
32. Li Kuang
33. Runkun Wang
34. Youhong Dong
35. Jianhai Sun
36. Wenbing Hu
37. Tienan Yi
38. Hanlin Wu
39. Mingyu Liu
40. Jiachen Xu
41. Jianchun Duan
42. Zhengyi Zhao
43. Guoqiang Wang
44. Yu Xu
45. Jie He

Reviewed by ScreenIT

Rapidly fatal pneumonitis from immunotherapy and concurrent SARS-CoV-2 infection in a patient with newly diagnosed lung cancer

1. Christine M. Lovly
2. Kelli L. Boyd
3. Paula I. Gonzalez-Ericsson
4. Cindy L. Lowe
5. Hunter M. Brown
6. Robert D. Hoffman
7. Brent C. Sterling
8. Meghan E. Kapp
9. Douglas B. Johnson
10. Prasad R. Kopparapu
11. Wade T. Iams
12. Melissa A. Warren
13. Michael J. Noto
14. Brian I. Rini
15. Madan Jagasia
16. Suman R. Das
17. Justin M. Balko

Reviewed by ScreenIT

ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19

1. Riyue Bao
2. Kyle Hernandez
3. Lei Huang
4. Jason John Luke

Reviewed by ScreenIT

Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic

1. A. Sud
2. M.E. Jones
3. J. Broggio
4. C. Loveday
5. B. Torr
6. A. Garrett
7. D.L. Nicol
8. S. Jhanji
9. S.A. Boyce
10. F. Gronthoud
11. P. Ward
12. J.M. Handy
13. N. Yousaf
14. J. Larkin
15. Y-E. Suh
16. S. Scott
17. P.D.P. Pharoah
18. C. Swanton
19. C. Abbosh
20. M. Williams
21. G. Lyratzopoulos
22. R. Houlston
23. C. Turnbull

Reviewed by ScreenIT

Implementation of a Novel Remote Physician Stereotactic Body Radiation Therapy Coverage Process during the Coronavirus Pandemic

1. Alex Price
2. Lauren E. Henke
3. Borna Maraghechi
4. Taeho Kim
5. Matthew B. Spraker
6. Geoffrey D. Hugo
7. Clifford G. Robinson
8. Nels C. Knutson

Reviewed by ScreenIT

A Multicenter Study of Coronavirus Disease 2019 Outcomes of Cancer Patients in Wuhan, China

1. Hongyan Zhang
2. Linwei Wang
3. Yuanyuan Chen
4. Xiaokun Shen
5. Qun Wang
6. Youqin Yan
7. Yi Yu
8. Qiuji Wu
9. Yahua Zhong
10. Melvin L.K. Chua
11. Conghua Xie

Reviewed by ScreenIT

Estimating the Risk of Death from COVID-19 in Adult Cancer Patients

1. M. Williams
2. E. Mi
3. K. Le Calvez
4. J. Chen
5. L. Pakzad-Shahabi
6. S. Dadhania
7. J. Wang
8. A. Ho
9. S. Rabinowicz

Reviewed by ScreenIT

Pan-Canadian survey on the impact of the COVID-19 pandemic on cervical cancer screening and management: cross-sectional survey of healthcare professionals

1. Mariam El-Zein
2. Rami Ali
3. Eliya Farah
4. Sarah Botting-Provost
5. Eduardo L Franco
6. Survey Study Group

• Curated by eLife

  eLife assessment

  This study explored practitioners' assessments of the impact of the pandemic on cervical cancer screening and follow-up. This is a very important topic that could continue to have implications for how this screening process is delivered now, after the pandemic. The authors need to more fully describe their methodology and temper conclusions to fit within those limitations.

Reviewed by eLife

Study of efficacy and longevity of immune response to third and fourth doses of COVID-19 vaccines in patients with cancer: A single arm clinical trial

1. Astha Thakkar
2. Kith Pradhan
3. Benjamin Duva
4. Juan Manuel Carreno
5. Srabani Sahu
6. Victor Thiruthuvanathan
7. Sean Campbell
8. Sonia Gallego
9. Tushar D Bhagat
10. Johanna Rivera
11. Gaurav Choudhary
12. Raul Olea
13. Maite Sabalza
14. Lauren C Shapiro
15. Matthew Lee
16. Ryann Quinn
17. Ioannis Mantzaris
18. Edward Chu
19. Britta Will
20. Liise-anne Pirofski
21. Florian Krammer
22. Amit Verma
23. Balazs Halmos

• Curated by eLife

  eLife assessment

  This important study evaluates the immunogenicity of 3rd and 4th doses of SARS-CoV2 vaccinations in patients with cancer. Their study is notable in that neutralization of Omicron was absent in all patients after the third dose but increased to 33% after the fourth dose. With the definitions and patient population better described, this paper would be of interest to those studying the effects of repeated COVID boosters on Omicron immunity.

Reviewed by eLife

Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

1. Richard C Lauer
2. Marc Barry
3. Tracey L Smith
4. Andrew Maltez Thomas
5. Jin Wu
6. Ruofei Du
7. Ji-Hyun Lee
8. Arpit Rao
9. Andrey S Dobroff
10. Marco A Arap
11. Diana N Nunes
12. Israel T Silva
13. Emmanuel Dias-Neto
14. Isan Chen
15. Dennis J McCance
16. Webster K Cavenee
17. Renata Pasqualini
18. Wadih Arap

• Curated by eLife

  eLife assessment

  Upregulation of PCA3 and downregulation of PRUNE2 in prostate cancer were first discovered in this work, which innovatively demonstrated that PCA3 and PRUNE3 function as an oncogene and a tumor suppressor gene respectively. The conclusion is further enhanced by the use of two distinct patient cohorts, which highlights the clinical significance. Functional experiments will be needed to more comprehensively validate the findings.

Reviewed by eLife