1. Conditional Survival and Nomogram for Elderly Non-Metastatic Colon Cancer Patients Following Colectomy

    This article has 6 authors:
    1. Yadong Gao
    2. Huimin Wang
    3. Yi Zhang
    4. Jing Zhao
    5. Sujuan Feng
    6. Jianwei Qiu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful work provides a risk-prediction tool, in the form of a nomogram, for practitioners and elderly patients with non-metastatic colon cancer using data from the SEER registry. The unique contribution of this work is the focus on conditional survival. However, the underlying statistical approach is suboptimal and therefore incomplete, which substantially lessens the potential impact of this work. The analysis could use a more rigorous consideration of competing risks.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regions

    This article has 4 authors:
    1. Apiwat Sangphukieo
    2. Pitiporn Noisagul
    3. Patcharawadee Thongkumkoon
    4. Parunya Chaiyawat
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides useful insights for anyone focusing on exonic regions when looking into the investigation of DNA fragmentation patterns (fragmentomics) for circulating tumor DNA (ctDNA) data for cancer detection. The method expands the DELFI method of Cristiano and colleagues (2019), but the datasets chosen are not ideal and the analysis remains incomplete.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study

    This article has 13 authors:
    1. Lijun Bian
    2. Zhimin Ma
    3. Xiangjin Fu
    4. Chen Ji
    5. Tianpei Wang
    6. Caiwang Yan
    7. Juncheng Dai
    8. Hongxia Ma
    9. Zhibin Hu
    10. Hongbing Shen
    11. Lu Wang
    12. Meng Zhu
    13. Guangfu Jin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents fundamental findings that advance our understanding of the role of phenotypic aging in cancer risk. This article presents compelling results that show Phenotypic Age Acceleration (PhenoAgeAccel) can predict cancer incidence of different types and could be used with genetic risk to facilitate the identification of cancer-susceptible individuals. These results will be of broad interest to the research community and clinicians.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

    This article has 15 authors:
    1. Jörn Lötsch
    2. Khayal Gasimli
    3. Sebastian Malkusch
    4. Lisa Hahnefeld
    5. Carlo Angioni
    6. Yannick Schreiber
    7. Sandra Trautmann
    8. Saskia Wedel
    9. Dominique Thomas
    10. Nerea Ferreiros Bouzas
    11. Christian Brandts
    12. Benjamin Schnappauf
    13. Christine Solbach
    14. Gerd Geisslinger
    15. Marco Sisignano
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Sisigano et al. report findings about the role of sphingolipids using lipidomics with machine learning in paclitaxel-induced peripheral neuropathy and preliminary translation of the impact of SA1P in cultured neuronal cells. This study presents a valuable finding on the increased activity of two well-studied signal transduction pathways in a subtype of breast cancer. The strength of evidence is incomplete with some support for the main claims with some limitations.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study

    This article has 14 authors:
    1. Yajing Chi
    2. Mu Su
    3. Dongdong Zhou
    4. Fangchao Zheng
    5. Baoxuan Zhang
    6. Ling Qiang
    7. Guohua Ren
    8. Lihua Song
    9. Bing Bu
    10. Shu Fang
    11. Bo Yu
    12. Jinxing Zhou
    13. Jinming Yu
    14. Huihui Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This prospective study advances our understanding of the predictive role of circulating tumor DNA (ctDNA) in the prognosis and of patients with mTNBC as well as other cancers. The evidence supporting the conclusions is convincing with rigorous analysis of the association between ctDNA (ctDNA-positive or not) with the progression-free survival (PFS) of patients. However, there are a few areas in which the article may be improved through further analysis of the clinical outcome and elaboration of the prospective study (i.e., the inclusion and exclusion criteria of the patients). The work will be of broad interest to clinicians, medical researchers and scientists working in cancers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Effects of neoadjuvant stereotactic body radiotherapy plus adebrelimab and chemotherapy for triple-negative breast cancer: A pilot study

    This article has 23 authors:
    1. Guanglei Chen
    2. Xi Gu
    3. Jinqi Xue
    4. Xu Zhang
    5. Xiaopeng Yu
    6. Yu Zhang
    7. Ailin Li
    8. Yi Zhao
    9. Guijin He
    10. Meiyue Tang
    11. Fei Xing
    12. Jianqiao Yin
    13. Xiaobo Bian
    14. Ye Han
    15. Shuo Cao
    16. Chao Liu
    17. Xiaofan Jiang
    18. Keliang Zhang
    19. Yan Xia
    20. Huajun Li
    21. Nan Niu
    22. Caigang Liu
    23. On behalf of the Northeastern Clinical Research Alliance of Oncology (NCRAO)
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding of a novel combinatory regimen which integrate immunotherapy, radiotherapy and chemotherapy in the current refractory triple negative breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to Clinicians working on breast cancer.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    This article has 65 authors:
    1. Van Thien Chi Nguyen
    2. Trong Hieu Nguyen
    3. Nhu Nhat Tan Doan
    4. Thi Mong Quynh Pham
    5. Giang Thi Huong Nguyen
    6. Thanh Dat Nguyen
    7. Thuy Thi Thu Tran
    8. Duy Long Vo
    9. Thanh Hai Phan
    10. Thanh Xuan Jasmine
    11. Van Chu Nguyen
    12. Huu Thinh Nguyen
    13. Trieu Vu Nguyen
    14. Thi Hue Hanh Nguyen
    15. Le Anh Khoa Huynh
    16. Trung Hieu Tran
    17. Quang Thong Dang
    18. Thuy Nguyen Doan
    19. Anh Minh Tran
    20. Viet Hai Nguyen
    21. Vu Tuan Anh Nguyen
    22. Le Minh Quoc Ho
    23. Quang Dat Tran
    24. Thi Thu Thuy Pham
    25. Tan Dat Ho
    26. Bao Toan Nguyen
    27. Thanh Nhan Vo Nguyen
    28. Thanh Dang Nguyen
    29. Dung Thai Bieu Phu
    30. Boi Hoan Huu Phan
    31. Thi Loan Vo
    32. Thi Huong Thoang Nai
    33. Thuy Trang Tran
    34. My Hoang Truong
    35. Ngan Chau Tran
    36. Trung Kien Le
    37. Thanh Huong Thi Tran
    38. Minh Long Duong
    39. Hoai Phuong Thi Bach
    40. Van Vu Kim
    41. The Anh Pham
    42. Duc Huy Tran
    43. Trinh Ngoc An Le
    44. Truong Vinh Ngoc Pham
    45. Minh Triet Le
    46. Dac Ho Vo
    47. Thi Minh Thu Tran
    48. Minh Nguyen Nguyen
    49. Thi Tuong Vi Van
    50. Anh Nhu Nguyen
    51. Thi Trang Tran
    52. Vu Uyen Tran
    53. Minh Phong Le
    54. Thi Thanh Do
    55. Thi Van Phan
    56. Hong-Dang Luu Nguyen
    57. Duy Sinh Nguyen
    58. Van Thinh Cao
    59. Thanh-Thuy Thi Do
    60. Dinh Kiet Truong
    61. Hung Sang Tang
    62. Hoa Giang
    63. Hoai-Nghia Nguyen
    64. Minh-Duy Phan
    65. Le Son Tran
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides insights into the early detection of malignancies with noninvasive methods by developing a framework, which assesses methylation, CNA, and other genomic features. They established a solid model in discriminating malignancies from healthy controls, as well as the ability to distinguish tumor of origin. This important study will demonstrate its practical impacts in the clinic and other researchers of the field.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute

    This article has 13 authors:
    1. Andreia C. de Melo
    2. Luiz C. S. Thuler
    3. Jesse L. da Silva
    4. Lucas Z. de Albuquerque
    5. Ana C. Pecego
    6. Luciana de O. R. Rodrigues
    7. Magda S. da Conceição
    8. Marianne M. Garrido
    9. Gelcio L. Quintella Mendes
    10. Ana Cristina P. Mendes Pereira
    11. Marcelo A. Soares
    12. João P. B. Viola
    13. on behalf of the Brazilian National Cancer Institute COVID-19 Task Force

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. The impact of the COVID-19 pandemic on quality of life, physical and psychosocial wellbeing in breast cancer patients – a prospective, multicenter cohort study

    This article has 16 authors:
    1. C. Bargon
    2. M. Batenburg
    3. L. van Stam
    4. D.Mink van der Molen
    5. I. van Dam
    6. F. van der Leij
    7. I. Baas
    8. M. Ernst
    9. W. Maarse
    10. N. Vermulst
    11. E. Schoenmaeckers
    12. T. van Dalen
    13. R. Bijlsma
    14. D. Young-Afat
    15. A. Doeksen
    16. H. Verkooijen

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Prevalence and risks of severe events for cancer patients with COVID-19 infection: a systematic review and meta-analysis

    This article has 9 authors:
    1. Qiang Su
    2. Jie-xuan Hu
    3. Hai-shan Lin
    4. Zheng Zhang
    5. Emily C. Zhu
    6. Chen-guang Zhang
    7. Di-ya Wang
    8. Zu-hua Gao
    9. Bang-wei Cao

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity