Neuroscience

Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis

1. Curran Landry
2. James Costanzo
3. Miguel Mitne-Neto
4. Mayana Zatz
5. Ashleigh Schaffer
6. Maria Hatzoglou
7. Alysson Muotri
8. Helen Cristina Miranda

Reviewed by Review Commons

Late maturation of semantic control promotes conceptual development

1. Rebecca L Jackson
2. Matthew A Lambon Ralph
3. Timothy T Rogers

• Curated by eLife

  eLife Assessment

  This study presents valuable findings suggesting that the late maturation of prefrontal cortex-based control processes enhances conceptual learning by allowing a period of less-constrained knowledge acquisition. The authors provide convincing computational evidence that delayed semantic control promotes learning without compromising representation integrity, with the strongest benefits emerging when control connections target intermediate layers of the model. However, the model's narrow scope raises concerns about scalability to more complex, real-world learning environments, and the meta-analysis, while supporting the developmental trajectory, does not directly test the model's specific predictions regarding task outcomes or error patterns.

Reviewed by eLife

Dual-action peptide shuttles prevent Cu-amyloid-β-induced neurotoxicity and relocate Cu intracellularly

1. Michael Okafor
2. David Schmitt
3. Enrico Falcone
4. Stéphane Gasman
5. Laurent Raibaut
6. Christelle Hureau
7. Peter Faller
8. Nicolas Vitale

Reviewed by Review Commons