Neuroscience

Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish

1. Evan Lloyd
2. Fanning Xia
3. Kinsley Moore
4. Carolina Zertuche Mery
5. Aakriti Rastogi
6. Robert A Kozol
7. Olga Kenzor
8. Wesley Warren
9. Lior Appelbaum
10. Rachel L Moran
11. Chongbei Zhao
12. Erik R Duboue
13. Nicolas Rohner
14. Alex C Keene

• Curated by eLife

  eLife Assessment

  Lloyd et al. used an evolutionary comparative approach to study DNA damage repair associated with low sleep duration in Astyanax mexicanus, highlighting how the cavefish population has evolved a reduced DNA damage response. The results presented here have important implications. Their results are generally solid however, the evidence suggesting that sleep differences are linked to DNA damage response is missing and this hypothesis remains to be fully tested.

Reviewed by eLife

A machine learning tool with light-based image analysis for automatic classification of 3D pain behaviors

1. Omer Barkai
2. Biyao Zhang
3. Bruna Lenfers Turnes
4. Maryam Arab
5. David A. Yarmolinsky
6. Zihe Zhang
7. Lee B. Barrett
8. Clifford J. Woolf

Reviewed by Arcadia Science

The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

1. Diellor Basha
2. Amirmohammad Azarmehri
3. Elian Proulx
4. Sylvain Chauvette
5. Maryam Ghorbani
6. Igor Timofeev

• Curated by eLife

  eLife Assessment

  The important manuscript presents convincing evidence of temporal correlations during specific oscillatory activity between the prefrontal cortex, thalamic nucleus reuniens, and the hippocampus, in naturally sleeping animals. Such correlations represent solid evidence to support the notion that the thalamic nucleus reuniens participates in the hippocampal and prefrontal cortex dialogue subserving memory processes.

Reviewed by eLife

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice

1. Marwa O Mikati
2. Petra Erdmann-Gilmore
3. Rose Connors
4. Sineadh M Conway
5. Jim Malone
6. Justin Woods
7. Robert W Sprung
8. Reid R Townsend
9. Ream Al-Hasani

• Curated by eLife

  eLife Assessment

  The authors adapt a previously-established method that permits detection of in vivo extracellular levels of two distinct enkephalin opioid peptides in response to stressful experiences in mice. The present study highlights the potential of measuring actual peptides by microdialysis-LC-MS. They use this approach in conjunction with fiber photometric calcium imaging to correlate enkephalin neuron activity and enkephalin release in response to repeated stress, providing convincing evidence that this improved approach can provide new insights into opioid signaling in-vivo. This important study provides a means to understand various behavioral states controlled by endogenous opioids and the nucleus accumbens, including hedonic and stress responses, in health and disease. This work will be of broad interest to the neuroscientific community.

Reviewed by eLife

Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss

1. Lorenzo Ghezzi
2. Ulrike Pech
3. Nils Schoovaerts
4. Suresh Poovathingal
5. Kristofer Davie
6. Jochen Lamote
7. Roman Praschberger
8. Patrik Verstreken

• Curated by eLife

  eLife Assessment

  The preliminary data presented in this manuscript seem valuable. The data are currently incomplete and there are numerous technical concerns, some of which may arise from insufficient description of methodologies used.

Reviewed by eLife

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

1. Erin M Ritchie
2. Dilan Acar
3. Siming Zhong
4. Qianyi Pu
5. Yunbo Li
6. Binhai Zheng
7. Yishi Jin

• Curated by eLife

  eLife Assessment

  This manuscript describes the impact of modulating signaling by a key regulatory enzyme, Dual Leucine Zipper Kinase (DLK), on hippocampal neurons. The results are interesting and will be important for scientists interested in synapse formation, axon specification, and cell death. The authors have carefully addressed the comments made by the reviewers and the findings are convincing in large part due to the use of extensive mouse genetics, detailed gene expression of enriched genes, and recognition of neuron vulnerability.

Reviewed by eLife

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

1. Aleksandra Prochera
2. Anoohya N Muppirala
3. Gavin A Kuziel
4. Salima Soualhi
5. Amy Shepherd
6. Liang Sun
7. Biju Issac
8. Harry J Rosenberg
9. Farah Karim
10. Kristina Perez
11. Kyle H Smith
12. Tonora H Archibald
13. Seth Rakoff-Nahoum
14. Susan J Hagen
15. Meenakshi Rao

• Curated by eLife

  eLife Assessment

  This study presents important findings on the function of enteric glia expressing proteolipid protein 1 (PLP1+ glia). The evidence supporting the claims of the authors is solid, although the inclusion of additional data showing the mechanisms by which PLP1+ enteric glia acts on Paneth cells would have strengthened the study. The work will be of interest to colleagues studying intestinal biology.

Reviewed by eLife

Visually-guided compensation of deafening-induced song deterioration

1. Manon Rolland
2. Anja T. Zai
3. Richard H. R. Hahnloser
4. Catherine Del Negro
5. Nicolas Giret

Reviewed by preLights

Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

1. James B Isbister
2. András Ecker
3. Christoph Pokorny
4. Sirio Bolaños-Puchet
5. Daniela Egas Santander
6. Alexis Arnaudon
7. Omar Awile
8. Barros-Zulaica Natali
9. Jorge Blanco Alonso
10. Elvis Boci
11. Giuseppe Chindemi
12. Jean-Denis Courcol
13. Tanguy Damart
14. Thomas Delemontex
15. Alexander Dietz
16. Gianluca Ficarelli
17. Mike Gevaert
18. Joni Herttuainen
19. Genrich Ivaska
20. Weina Ji
21. Daniel Keller
22. James King
23. Pramod Kumbhar
24. Samuel Lapere
25. Polina Litvak
26. Darshan Mandge
27. Eilif B Muller
28. Fernando Pereira
29. Judit Planas
30. Rajnish Ranjan
31. Maria Reva
32. Armando Romani
33. Christian Rössert
34. Felix Schürmann
35. Vishal Sood
36. Aleksandra Teska
37. Anil Tuncel
38. Werner Van Geit
39. Matthias Wolf
40. Henry Markram
41. Srikanth Ramaswamy
42. Michael W Reimann

• Curated by eLife

  eLife Assessment

  This study reports a model of 8 somatosensory areas of the rat cortex consisting of 4.2 million morphologically and electrically detailed neurons. The authors carry out simulation experiments aimed at understanding how multiscale organization of the cortical network shapes neural activity. While the reviewers found the results to be solid, they note that they could have likely been obtained using a much smaller portion of the model. Nonetheless, the release of the modeling platform represents a significant contribution to the field by providing a valuable resource for the scientific community.

Reviewed by eLife

Robust variability of grid cell properties within individual grid modules enhances encoding of local space

1. William T Redman
2. Santiago Acosta-Mendoza
3. Xue-Xin Wei
4. Michael J Goard

• Curated by eLife

  eLife Assessment

  This valuable study examines the variability in spacing and direction of entorhinal grid cells, providing convincing evidence that such variability helps disambiguate locations within an environment. This study will be of interest to neuroscientists working on spatial navigation and, more broadly, on neural coding.

Reviewed by eLife