Neuroscience

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

1. Carmen Muñoz-Ballester
2. Owen Leitzel
3. Samantha Golf
4. Chelsea M Phillips
5. Michael J Zeitz
6. Rahul Pandit
7. Elizabeth Wash
8. Jenna V. Donohue
9. James W. Smyth
10. Samy Lamouille
11. Stefanie Robel

Reviewed by Review Commons

Working memory shapes neural geometry in human EEG over learning

1. Michał J Wójcik
2. Amy Li
3. Dante Wasmuht
4. Jake P Stroud
5. Mark G Stokes
6. Nicholas E Myers
7. Laurence T Hunt

• Curated by eLife

  eLife Assessment

  The findings are valuable, given that they highlight the flexible and future-oriented nature of working memory. However, the evidence for the claims about context/color generalization, behavioural relevance of context decoding, dimensionality reduction, neural geometry, the XOR representation, and the specific contribution of working memory is incomplete. The work could be reframed in terms of prospective remapping.

Reviewed by eLife

Development of the axonal βII-spectrin periodic skeleton requires active cytoskeletal remodelling

1. Shivani Bodas
2. Ashish Mishra
3. Pramod Pullarkat
4. Aurnab Ghose

• Curated by eLife

  eLife Assessment

  This study examines how the neuronal cytoskeleton contributes to the formation of the axonal membrane-associated periodic skeleton (MPS) in embryonic dorsal root ganglia (DRG) neurons, using STED imaging. Conclusions are supported by convincing methods, data, and analyses. This useful work confirms previous data and improves our understanding of the roles of microtubules and actin dynamics in the chronological recruitment of MPS components.

Reviewed by eLife

A theory and recipe to construct general and biologically plausible integrating continuous attractor neural networks

1. Federico Claudi
2. Sarthak Chandra
3. Ila R Fiete

• Curated by eLife

  eLife Assessment

  This valuable study presents a theoretical framework for building continuous attractor networks that integrate with a wide range of topologies, which are of increasing relevance to neuroscientists. While the work offers solid evidence for most claims, the evidence supporting biological plausibility and key claims - such as the existence of a continuum of stable states and robustness across geometries - is currently incomplete and would benefit from further analysis or discussion. The study will be of interest to computational and systems neuroscientists working on neural dynamics and network models of cognition.

Reviewed by eLife

Structural and functional evidence supports re-defining mouse higher order visual areas into a single area V2

1. Declan P Rowley
2. Madineh Sedigh-Sarvestani

• Curated by eLife

  eLife Assessment

  This paper performs a valuable critical reassessment of anatomical and functional data, proposing a reclassification of the mouse visual cortex in which almost all the higher visual areas are consolidated into a single area V2. However, the evidence supporting this unification is incomplete, as the key experimental observations that the model attempts to reproduce do not accurately reflect the literature. This study will likely be of interest to neuroscientists focused on the mouse visual cortex and the evolution of cortical organization.

Reviewed by eLife