Neuroscience

Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care

1. Juliet Jiang
2. Jeffrey R. Petrella
3. Wenrui Hao
4. the Alzheimer’s Disease Neuroimaging Initiative

Reviewed by preLights

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

1. Jennifer Freire
2. Joshua E. McGee
3. Max Heinrich
4. Elijah Hammarlund
5. Sicheng Pang
6. Dana Shaw
7. Yuxin Zhou
8. Yangyang Wang
9. Colin Porter
10. Lauren Dang
11. Erynne San Antonio
12. Ziqing Yu
13. Kexin Li
14. Scellig Stone
15. Hart Lidov
16. Jordan Farrell
17. Emily K. Osterweil
18. Wilson W. Wong
19. Mark W. Grinstaff
20. Xue Han

Reviewed by Arcadia Science

The inevitability and superfluousness of cell types in spatial cognition

1. Xiaoliang Luo
2. Robert M Mok
3. Bradley C Love

• Curated by eLife

  eLife Assessment

  This important study demonstrates that some degree of spatial tuning (e.g., place cells) and ability to decode spatial location emerges in sufficiently complex systems trained to process visual information. This intriguing observation challenges existing approaches and findings used in the study of spatial navigation. However, the strength of evidence regarding the nature and quality of spatial tuning, its compatibility with experimental data, and the overall interpretation of the study remains incomplete. This work will be of interest to the research community of spatial navigation.

Reviewed by eLife

Extracting Value Coding Features from Individual Serotonin Neurons

1. Emerson F Harkin
2. Jean-Claude Béïque
3. Richard Naud

• Curated by eLife

  eLife Assessment

  The authors used a Bayesian modeling framework to fit behavior and serotonin neuron activity to reward history across multiple timescales. A key goal was to distinguish value coding from other influences, particularly thirst, by comparing model fits across neurons. Although the question and approach are valuable, several limitations of the current manuscript mean that support for the conclusions is incomplete.

Reviewed by eLife

Synaptic density and relative connectivity conservation maintain circuit stability across development

1. Ingo Fritz
2. Feiyu Wang
3. Ricardo Chirif
4. Nikos Malakasis
5. Julijana Gjorgjieva
6. André Ferreira Castro

• Curated by eLife

  eLife Assessment

  The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself is solid, the authors have drawn broader conclusions than are directly supported by the presented data. With more measured claims and greater clarity and explanations for the analysis, the study could potentially become stronger.

Reviewed by eLife

Comparing electromyography, accelerometry, and visual inspection to assess the resting motor threshold for transcranial magnetic stimulation

1. Gautier Hamoline
2. Antoine E Lunardi
3. Marcos Moreno-Verdú
4. Baptiste M Waltzing
5. Elise E Van Caenegem
6. Siobhan MacAteer
7. Robert M Hardwick

Reviewed by Peer Community in Neuroscience