Neuroscience

Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs

1. Jiro Yoshino
2. Avery Chiu
3. Takeshi Morita
4. Chang Yin
5. Federico M. Tenedini
6. Takaaki Sokabe
7. Kazuo Emoto
8. Jay Z. Parrish

Reviewed by Review Commons

A Scene with an Invisible Wall—Navigational Experience Shapes Visual Scene Representation

1. Shi Pui Donald Li
2. Jiayu Shao
3. Zhengang Lu
4. Michael McCloskey
5. Soojin Park

• Curated by eLife

  eLife assessment

  This important study provides novel evidence that navigational experiences can shape perceptual scene representations. The evidence presented is incomplete and would benefit from clearer explanations of the experiment design and careful discussion of alternative interpretations such as contextual associations or familiarity. The work will be of interest to cognitive psychologists and neuroscientists working on perception and navigation.

  [Editors’ note: A revised version of this work has been published in the Journal of Cognitive Neuroscience (DOI: https://doi.org/10.1162/JOCN.a.2409).]

Reviewed by eLife

Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care

1. Juliet Jiang
2. Jeffrey R. Petrella
3. Wenrui Hao
4. the Alzheimer’s Disease Neuroimaging Initiative

Reviewed by preLights

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

1. Jennifer Freire
2. Sicheng Pang
3. Joshua E McGee
4. Maxwell J Heinrich
5. Jiancheng Xie
6. Elijah Hammarlund
7. Dana Shaw
8. Yuxin Zhou
9. Yangyang K Wang
10. Colin Porter
11. Lauren Dang
12. Erynne San Antonio
13. Ziqing Yu
14. Kexin Li
15. Scellig Stone
16. Hart Lidov
17. Jordan Farrell
18. Emily K Osterweil
19. Wilson Wong
20. Mark Grinstaff
21. Xue Han

Reviewed by Arcadia Science

The inevitability and superfluousness of cell types in spatial cognition

1. Xiaoliang Luo
2. Robert M Mok
3. Bradley C Love

• Curated by eLife

  eLife Assessment

  This important study demonstrates that some degree of spatial tuning (e.g., place cells) and ability to decode spatial location emerges in sufficiently complex systems trained to process visual information. This intriguing observation challenges existing approaches and findings used in the study of spatial navigation. However, the strength of evidence regarding the nature and quality of spatial tuning, its compatibility with experimental data, and the overall interpretation of the study remains incomplete. This work will be of interest to the research community of spatial navigation.

Reviewed by eLife

Extracting Value Coding Features from Individual Serotonin Neurons

1. Emerson F Harkin
2. Jean-Claude Béïque
3. Richard Naud

• Curated by eLife

  eLife Assessment

  The authors used a Bayesian modeling framework to fit behavior and serotonin neuron activity to reward history across multiple timescales. A key goal was to distinguish value coding from other influences, particularly thirst, by comparing model fits across neurons. Although the question and approach are valuable, several limitations of the current manuscript mean that support for the conclusions is incomplete.

Reviewed by eLife