Neuroscience

Regulation of sensorimotor serial learning in speech production by motor compensation rather than sensory error

1. Yuhan Lu
2. Xiaowei Tang
3. Zhenyan Xiao
4. Anqi Xu
5. Junxi Chen
6. Xing Tian

• Curated by eLife

  eLife Assessment

  This study investigates how people adapt their speech when auditory feedback is altered. The analyses are rigorous and the work makes a valuable contribution by extending methods from limb motor control to speech. However, because the paradigm does not directly measure sensory error, the evidence for the proposed mechanism of sensorimotor learning is incomplete. The findings are best viewed as evidence for how prior motor adjustments influence subsequent behaviour, highlighting the need for future studies to more precisely separate sensory and motor contributions to adaptation.

Reviewed by eLife

Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampal formation

1. Eirik S Nilssen
2. Bente Jacobsen
3. Thanh P Doan
4. Paulo JB Girão
5. Menno P Witter

• Curated by eLife

  eLife Assessment

  This study provides a valuable insight into how the medial and lateral entorhinal cortices interact through distinct excitatory and inhibitory pathways. Using anatomical tracing, optogenetics, and electrophysiology, the authors show that glutamatergic medial entorhinal neurons provide broad excitatory input to lateral entorhinal, while long-range SST+ interneurons deliver selective inhibition to layer I. These findings reveal a novel layer- and cell-type-specific organization of medial to lateral entorhinal connectivity with implications for spatial and episodic memory. The work is solid, but validation of injection specificity and viral spread is needed to fully confirm the anatomical interpretations; with these clarifications, this will be a significant contribution to understanding entorhinal-hippocampal circuit organization.

Reviewed by eLife

Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs

1. Jiro Yoshino
2. Avery Chiu
3. Takeshi Morita
4. Chang Yin
5. Federico M. Tenedini
6. Takaaki Sokabe
7. Kazuo Emoto
8. Jay Z. Parrish

Reviewed by Review Commons

A Scene with an Invisible Wall—Navigational Experience Shapes Visual Scene Representation

1. Shi Pui Donald Li
2. Jiayu Shao
3. Zhengang Lu
4. Michael McCloskey
5. Soojin Park

• Curated by eLife

  eLife assessment

  This important study provides novel evidence that navigational experiences can shape perceptual scene representations. The evidence presented is incomplete and would benefit from clearer explanations of the experiment design and careful discussion of alternative interpretations such as contextual associations or familiarity. The work will be of interest to cognitive psychologists and neuroscientists working on perception and navigation.

  [Editors’ note: A revised version of this work has been published in the Journal of Cognitive Neuroscience (DOI: https://doi.org/10.1162/JOCN.a.2409).]

Reviewed by eLife

Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care

1. Juliet Jiang
2. Jeffrey R. Petrella
3. Wenrui Hao
4. the Alzheimer’s Disease Neuroimaging Initiative

Reviewed by preLights

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

1. Jennifer Freire
2. Sicheng Pang
3. Joshua E. McGee
4. Maxwell J. Heinrich
5. Jiancheng Xie
6. Elijah Hammarlund
7. Dana Shaw
8. Yuxin Zhou
9. Yangyang Wang
10. Colin Porter
11. Lauren Dang
12. Erynne San Antonio
13. Ziqing Yu
14. Kexin Li
15. Scellig Stone
16. Hart Lidov
17. Jordan Farrell
18. Emily K. Osterweil
19. Wilson W. Wong
20. Mark W. Grinstaff
21. Xue Han

Reviewed by Arcadia Science