Neuroscience

Maximized field-of-view deep-brain calcium imaging through gradient-index lenses

1. Chenmao Wang
2. Zongyue Cheng
3. Yuting Li
4. Jianian Lin
5. Meng Cui

• Curated by eLife

  eLife Assessment

  This study presents a valuable and practical approach for one-photon imaging through GRIN lenses. By scanning a low numerical aperture (NA) beam and collecting fluorescence with a high NA, the method expands the usable field of view and yields clearer cellular signals. The evidence is solid overall, with strong qualitative demonstrations, but some claims would benefit from additional quantitative tests. The work will interest researchers who need simple, scalable tools for large‑area cellular imaging in the brain.

Reviewed by eLife

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes

1. LaShae Nicholson
2. Si Jie Tang
3. Tejaswini Karra
4. Habiba Abouelatta
5. Stephen M. Strittmatter

Reviewed by PREreview

Shaker it OFF: Biophysical Characterization of an Inactivating Potassium Conductance Mediating Object Segmentation in a Collision-Detecting Neuron

1. Gil Shaulsky
2. David Bellini
3. Dylan Ulloa
4. Eleni Nasiotis
5. Hala Khan
6. Hongxia Wang
7. Jiayi Luo
8. Herman Dierick
9. Chenghang Zong
10. Fabrizio Gabbiani
11. Richard B. Dewell

Reviewed by PREreview

Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s disease

1. Rebecca L. Pinals
2. Md Rezaul Islam
3. Oisín King
4. Aaron Choi
5. Eulim Kang
6. Masayuki Nakano
7. Anjanet Tuyéras
8. Maeesha Tasnim Naomi
9. Arthur Ngo
10. Alan Jiang
11. Nhat Truong
12. Emre Agbas
13. Claudia F. Lozano Cruz
14. Colin Staab
15. Tak Ko
16. David A. Bennett
17. Alice E. Stanton
18. Robert Langer
19. Li-Huei Tsai

Reviewed by PREreview