1. Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

    This article has 8 authors:
    1. Patricia E Phelps
    2. Sung Min Ha
    3. Rana R Khankan
    4. Mahlet A Mekonnen
    5. Giovanni Juarez
    6. Kaitlin L Ingraham Dixie
    7. Yen-Wei Chen
    8. Xia Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study unveils important data describing cell states of olfactory ensheathing cells, and how these cell states may relate to repair after spinal cord injury. The framework used for characterizing these cells is solid. This work will be of interest to stem cell biologists and spinal cord injury researchers.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target

    This article has 2 authors:
    1. Lisa M Kroell
    2. Martin Rolfs
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports important findings about pre-saccadic foveal prediction and the extent to which it is influenced by the visibility of the saccade target relative to its background. The research methodology and results make a convincing case that foveal congruency effects develop when salient local contrast variations at the saccade target location can be used to direct the eye movement. This work should be of broad interest to visual neuroscientists, as well as those interested in understanding perception in the context of eye movements and in modeling visually guided actions.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  3. Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    This article has 15 authors:
    1. Jiro Yoshino
    2. Sonali S Mali
    3. Claire R Williams
    4. Takeshi Morita
    5. Chloe E Emerson
    6. Christopher J Arp
    7. Sophie E Miller
    8. Chang Yin
    9. Lydia Thé
    10. Chikayo Hemmi
    11. Mana Motoyoshi
    12. Kenichi Ishii
    13. Kazuo Emoto
    14. Diana M Bautista
    15. Jay Z Parrish
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is important work and provides a significant advance in our understanding of mechanosensation in the epidermis. The evidence presented is convincing and, barring a few minor weaknesses, strongly implicates activation of epidermal cells and store-operated calcium entry in the activation of nociceptive neurons innervating that tissue. This work will be of broad interest to neurobiologists, epithelial cell biologists, and mechanobiologists.

    Reviewed by eLife, Arcadia Science

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  4. Anterior cingulate cortex in complex associative learning: monitoring action state and action content

    This article has 6 authors:
    1. Wenqiang Huang
    2. Arron F Hall
    3. Natalia Kawalec
    4. Ashley N Opalka
    5. Jun Liu
    6. Dong V Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Huang and colleagues examined neural responses in mouse anterior cingulate cortex (ACC) during a discrimination-avoidance task. The authors present useful findings that ACC neurons encode primarily post-action variables over extended periods rather than the outcomes or values of those actions. Though the methodological approach was sound, the evidence ruling out alternative explanations is incomplete and requires substantial control analyses.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction

    This article has 8 authors:
    1. Ramesh Chittajallu
    2. Anna Vlachos
    3. Xiaqing Yuan
    4. Steven Hunt
    5. Ddaniel Abebe
    6. Edra London
    7. Kenneth A Pelkey
    8. Chris J McBain
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important information about the role of mu opioid receptors in synaptic communication between the medial habenula and the interpeduncular nucleus. The authors provide solid evidence that mu opioid receptor activation has differential effects on glutamate release from substance P neurons and cholinergic neurons, with a canonical reduction in release from the former but a novel increase in release from the latter. They also show that blocking potassium channels can unmask a nicotinic cholinergic synaptic response that is also facilitated by mu opioid receptor activation. This work will be of interest to those studying the interpeduncular nucleus, as well as the larger neuroscience community studying opioids and motivated behavior.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Mapping Visual Contrast Sensitivity and Vision Loss Across the Visual Field with Model-Based fMRI

    This article has 8 authors:
    1. Hugo T Chow-Wing-Bom
    2. Matteo Lisi
    3. Noah C Benson
    4. Freya Lygo-Frett
    5. Patrick Yu-Wai-Man
    6. Frederic Dick
    7. Roni O Maimon-Mor
    8. Tessa M Dekker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Using fMRI-based pRF mapping, this important study presents a novel method to estimate visual field (VF) and VF loss/or potential restoration, through analysis of contrast sensitivity patterns in the early visual cortex. While the approach is very interesting and the evidence supporting the claims of the authors is solid, some methodological concerns need to be addressed. The work will be of interest to researchers in vision/clinical vision, neuroscience, and brain imaging.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Olfactory combinatorial coding supports risk-reward decision making in C. elegans

    This article has 8 authors:
    1. Md Zubayer Hossain Saad
    2. William G Ryan
    3. Chelyan A Edwards
    4. Benjamin N Szymanski
    5. Aryan R Marri
    6. Lilian G Jerow
    7. Robert McCullumsmith
    8. Bruce A Bamber
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study shows that an odorant that is typically thought of as a repellant actually activates both attractant and repellant olfactory neurons in C. elegans. Solid evidence is provided that nematode worms can integrate signals using different pathways to drive different behavioral responses to the same cue. These findings will be of interest to scientists interested in combinatorial coding in sensory systems.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Sense of control buffers against stress

    This article has 5 authors:
    1. Jennifer C Fielder
    2. Jinyu Shi
    3. Daniel McGlade
    4. Quentin JM Huys
    5. Nikolaus Steinbeis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important research addresses the effects of subjective control and task difficulty on experienced stress using a novel behavioral task in two, large online samples. Convincing evidence is provided, establishing internal and external task validity and a relationship with individual differences in relevant mental health constructs. Evidence for the core claims could be strengthened by disentangling the effects of controllability from those of reward rate and adjusting data parcellation for computing internal consistency. This work will be of interest to psychologists and clinicians studying controllability, stress, and psychopathology.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum

    This article has 2 authors:
    1. Silas E Busch
    2. Christian Hansel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a convincing study of the morphological properties of Purkinje cell dendrites and dendritic spines in adult humans and mice, and the anatomical determinants of multi-innervation by climbing fibers. The data will provide an important resource for the field of cerebellar computation.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    This article has 9 authors:
    1. Hyun Beom Song
    2. Laura Campello
    3. Anupam Mondal
    4. Holly Y Chen
    5. Milton A English
    6. Michael Glen
    7. Phillip Vanlandingham
    8. Rafal Farjo
    9. Anand Swaroop
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important Research Advance presents compelling evidence on the neuroprotective effects of reserpine in a well-established model of retinitis pigmentosa (P23H-1). This study builds on previous work establishing reserpine as a neuroprotectant in models of Leber congenital amaurosis. Here authors show reserpine's disease gene-independent influence on photoreceptor survival and emphasizes the importance of considering biological sex in understanding inherited retinal degeneration and the impact of drug treatments on mutant retinas. The work will be of interest to vision researchers as well as a broad audience in translational research.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
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