Neuroscience

Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency

1. Vi Pham
2. Lucas Tricoli
3. Xinying Hong
4. Parith Wongkittichote
5. Carlo Castruccio Castracani
6. Amaliris Guerra
7. Lars Schlotawa
8. Laura A. Adang
9. Amanda Kuhs
10. Margaret M. Cassidy
11. Owen Kane
12. Emily Tsai
13. Maximiliano Presa
14. Cathleen Lutz
15. Stefano B. Rivella
16. Rebecca C. Ahrens-Nicklas

Reviewed by Arcadia Science

How Occam’s razor guides human decision-making

1. Eugenio Piasini
2. Shuze Liu
3. Pratik Chaudhari
4. Vijay Balasubramanian
5. Joshua I Gold

• Curated by eLife

  eLife Assessment

  This study presents an important new approach to quantifying parsimony preferences in human inference. The work provides convincing evidence that humans are sensitive to specific formalizations of parsimony, such as the dimensionality of perceptual shapes. The work is considered timely, well-written, and technically sophisticated, effectively bridging concepts from statistical inference and human decision-making.

Reviewed by eLife

EEG decodability of facial expressions and their stereoscopic depth cues in immersive virtual reality

1. Felix Klotzsche
2. Ammara Nasim
3. Simon M Hofmann
4. Arno Villringer
5. Vadim Nikulin
6. Werner Sommer
7. Michael Gaebler

• Curated by eLife

  eLife Assessment

  This valuable study successfully decoded visual representations of facial expressions and stereoscopic depth information from electroencephalogram (EEG) signals recorded in an immersive virtual reality (VR) environment. The evidence is solid in demonstrating the technical feasibility of integrating state-of-the-art EEG decoding and VR with eye tracking. This work will interest neuroscience researchers, as well as engineers developing brain-machine interfaces and/or virtual reality displays.

Reviewed by eLife

Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

1. Chi-Hong Wu
2. Gina G Turrigiano

• Curated by eLife

  eLife Assessment

  This valuable study provides solid evidence for deficits in aversive taste learning and taste coding in a mouse model of autism spectrum disorders. Specifically, the authors found that Shank3 knockout mice exhibit behavioral deficits in learning and extinction of conditioned taste aversion, and calcium imaging of the gustatory cortex identified impaired neuronal responses to taste stimuli. This paper will likely be of interest to researchers studying how learning and sensory processes are affected by genetic causes of autism spectrum disorders.

Reviewed by eLife

Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation

1. Heath L. Robinson
2. Ralitsa Todorova
3. Gergo A. Nagy
4. Anna Gruzdeva
5. Praveen Paudel
6. Azahara Oliva
7. Antonio Fernandez-Ruiz

Reviewed by PREreview