1. The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

    This article has 17 authors:
    1. Tingbo Li
    2. Ling Yang
    3. Jiaqi Tu
    4. Yufan Hao
    5. Zhu Zhu
    6. Yingjie Xiong
    7. Qingzhu Gao
    8. Lili Zhou
    9. Guanglei Xie
    10. Dongdong Zhang
    11. Xuzhao Li
    12. Yuxiao Jin
    13. Yiyi Zhang
    14. Bingrui Zhao
    15. Nan Li
    16. Xi Wang
    17. Jie-Min Jia
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study aims to understand the role of endothelial cell differentiation into pericytes in the restoration of blood-brain barrier function after ischemic stroke. Identification of pericytes derived from endothelial cells and the involvement of myeloid cell-derived TGFβ1 signaling are compelling new findings, but future studies will be needed to validate the origin and nature of these pericytes. The work will be of interest to blood-brain barrier and basic and translational stroke researchers.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Neurons throughout the brain embed robust signatures of their anatomical location into spike trains

    This article has 4 authors:
    1. Gemechu Bekele Tolossa
    2. Aidan M Schneider
    3. Eva Dyer
    4. Keith B Hengen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper provides a useful systematic quantification of the relationship between electrophysiological response properties of single neurons with their position in the brain. The quality of the classification setup is high and the methodology is solid.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. A theory of brain-computer interface learning via low-dimensional control

    This article has 9 authors:
    1. Jorge A Menéndez
    2. Jay A Hennig
    3. Matthew D Golub
    4. Emily R Oby
    5. Patrick T Sadtler
    6. Aaron P Batista
    7. Steven M Chase
    8. Byron M Yu
    9. Peter E Latham
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study proposes a network implementation of the "re-aiming" learning strategy, which has been hypothesized to underlie brain-computer interface learning. Combining theoretical arguments, numerical simulations, and analysis of experimental data, the authors provide convincing evidence for their hypothesis. This paper will likely be of broad interest to the systems neuroscience community.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Hierarchy between forelimb premotor and primary motor cortices and its manifestation in their firing patterns

    This article has 9 authors:
    1. Akiko Saiki-Ishikawa
    2. Mark Agrios
    3. Sajishnu Savya
    4. Adam Forrest
    5. Hannah Sroussi
    6. Sarah Hsu
    7. Diya Basrai
    8. Feihong Xu
    9. Andrew Miri
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides important insights as to how interacting brain areas produce movement during the execution of a skilled multi-directional reaching task. Using a combination of single neuron and neural population analysis, optogenetic stimulation, and computational models, the authors provide convincing evidence of an asymmetrical influence between mouse premotor and motor cortex during the execution of a well-practiced behaviour. This asymmetry can only be captured by some but not all population analysis methods, which is a key lesson to the field in and of itself. Analyzing how activity that is shared and private to these areas relates to different aspects of movements, and why different methods provide different outcomes regarding the nature of inter-area interactions would further strengthen this work.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  5. Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

    This article has 3 authors:
    1. Emily E Oor
    2. Emilio Salinas
    3. Terrence R Stanford
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Oor and colleagues report the potentially independent effects of the spatial and feature-based selection history on visuomotor choices. They outline compelling evidence, tracking the dynamic history effects based on their extremely clever experimental design (urgent version of the search task). Their finding is of fundamental significance, broadening the framework to identify variables contributing to choice behavior and their neural correlates in future studies.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. AgRP1 modulates breeding season-dependent feeding behavior in female medaka

    This article has 9 authors:
    1. Yurika Tagui
    2. Shingo Takeda
    3. Hiroyo Waida
    4. Shoichi Kitahara
    5. Tomoki Kimura
    6. Shinji Kanda
    7. Yoshitaka Oka
    8. Yu Hayashi
    9. Chie Umatani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides fundamental new insight into the mechanisms linking photoperiod, reproduction function, and feeding activity, using medaka, a genetic model that itself exhibits photoperiodic responses. As well as identifying key neuropeptide genes that are regulated by photoperiod and involved in regulating feeding activity, the authors establish a knockout line for agrp1 using CRISPR Cas9 - based approach, profiting from the extensive use and development on this methodology in medaka. The combination of the RNAseq and quantitative in situ hybridization analysis with the knockout results as well as the study of ovariectomized fish provides compelling evidence implicating agrp1 in feeding regulation in response to photoperiod and reproductive status.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis

    This article has 6 authors:
    1. Johanna Ganssauge
    2. Sophie Hawkins
    3. Seema Chandramohan Namboori
    4. Szi Kay Leung
    5. Jonathan Mill
    6. Akshay Bhinge
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      TDP-43 mislocalization is a key feature of some neurodegenerative diseases, but cellular models are lacking. The authors endogenously-tagged TDP-43 with a C-terminal GFP tag in human iPSCs, followed by expression of an intrabody-NES that targeted GFP to the cytosol. They convincingly report physical mislocalization and functional depletion of TDP-43, as measured by microscopy and RNAseq. This method will be valuable to investigators studying the biological consequences of TDP-43 mislocalization and the methodology is in line with the current state-of-the-art.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  8. Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking

    This article has 5 authors:
    1. Juliane Schubert
    2. Quirin Gehmacher
    3. Fabian Schmidt
    4. Thomas Hartmann
    5. Nathan Weisz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      These are valuable findings for those interested in how neural signals reflect auditory speech streams, and in understanding the roles of prediction, attention, and eye movements in this tracking. However, the evidence as it stands is incomplete. Further analyses are needed to clarify how the observed results relate to the relevant theoretical claims.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    This article has 34 authors:
    1. Adam Glaser
    2. Jayaram Chandrashekar
    3. Sonya Vasquez
    4. Cameron Arshadi
    5. Rajvi Javeri
    6. Naveen Ouellette
    7. Xiaoyun Jiang
    8. Judith Baka
    9. Gabor Kovacs
    10. Micah Woodard
    11. Shamishtaa Seshamani
    12. Kevin Cao
    13. Nathan Clack
    14. Andrew Recknagel
    15. Anna Grim
    16. Pooja Balaram
    17. Emily Turschak
    18. Marcus Hooper
    19. Alan Liddell
    20. John Rohde
    21. Ayana Hellevik
    22. Kevin Takasaki
    23. Lindsey Erion Barner
    24. Molly Logsdon
    25. Chris Chronopoulos
    26. Saskia EJ de Vries
    27. Jonathan T Ting
    28. Steven Perlmutter
    29. Brian E Kalmbach
    30. Nikolai Dembrow
    31. Bosiljka Tasic
    32. R Clay Reid
    33. David Feng
    34. Karel Svoboda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The ExA-SPIM methodology developed here and characterized and supported by convincing evidence is an important development for the field of light sheet microscopy as the new technology provides an impressive field of view making it possible to image the entire expanded mouse brain at cellular and subcellular resolution.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 2 listsLatest version Latest activity
  10. Cellular and synaptic organization of the Octopus vertical lobe

    This article has 5 authors:
    1. Flavie Bidel
    2. Yaron Meirovitch
    3. Fuming Yang
    4. Jeff William Lichtman
    5. Binyamin Hochner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study of the inhibitory complex amacrines (CAM) in the vertical lobe of Octopus vulgaris delivers a solid standard for the structural characterization of an anatomical region likely to be key for memory processing in this unconventional but complex organism, as well as a helpful classification of CAM subtypes. This work will be of broad relevance to the fields of memory and evolutionary neuroscience.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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