Neuroscience

Neural population dynamics underlying evidence accumulation in multiple rat brain regions

1. Brian DePasquale
2. Carlos D. Brody
3. Jonathan W. Pillow

• Curated by eLife

  eLife assessment

  This valuable paper presents findings showing that different brain regions were best described by a distinct accumulation model, which all differed from the model that best described the rat's choices. These findings are solid because the authors present a very strong methodological approach. This work will be of interest to a wide neuroscientific audience.

Reviewed by eLife

Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

1. Katrin Franke
2. Chenchen Cai
3. Kayla Ponder
4. Jiakun Fu
5. Sacha Sokoloski
6. Philipp Berens
7. Andreas Savas Tolias

• Curated by eLife

  eLife assessment

  Franke et al. explore and characterize color response properties of neurons in mouse primary visual cortex (V1), revealing specific color opponent encoding strategies across the visual field. The paper provides evidence for the existence of color opponency in a subset of neurons within V1 and shows that these color opponent neurons are more numerous in the upper visual field. Support for the main conclusions is convincing and the dataset that forms the basis of the paper is impressive. The paper will make an important contribution to understanding how color is coded in mouse V1.

Reviewed by eLife

Future movement plans interact in sequential arm movements

1. Mehrdad Kashefi
2. Sasha Reschechtko
3. Giacomo Ariani
4. Mahdiyar Shahbazi
5. Alice Tan
6. Jörn Diedrichsen
7. J Andrew Pruszynski

• Curated by eLife

  eLife assessment

  This study presents an important set of results illuminating how movement sequences are planned. Using several different behavioural manipulations and analysis methods, the authors present compelling evidence that multiple future movements are planned simultaneously with execution, and that these future movement plans influence each other. The work will be of great interest to those studying motor control.

Reviewed by eLife

Is ChatGPT detrimental to innovation? A field experiment among university students

1. Mazen Hassan
2. Engi Amin
3. Sarah Mansour
4. Zeyad Kelani

Reviewed by PREreview

Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

1. Srdjan Sumarac
2. Kiah A Spencer
3. Leon A Steiner
4. Conor Fearon
5. Emily A Haniff
6. Andrea A Kühn
7. Mojgan Hodaie
8. Suneil K Kalia
9. Andres Lozano
10. Alfonso Fasano
11. William Duncan Hutchison
12. Luka Milosevic

• Curated by eLife

  eLife assessment

  This manuscript is a valuable study of the responses of GPi neurons to deep brain stimulation (DBS) in human Parkinson disease and dystonia patients and it finds convincing evidence for altered short-term and long-term plasticity in response to DBS between the two patient populations. This dataset is of interest to both basic and clinical researchers working in the field of DBS and movement disorders.

Reviewed by eLife

Difficulty in artificial word learning impacts targeted memory reactivation and its underlying neural signatures

1. Arndt-Lukas Klaassen
2. Björn Rasch

• Curated by eLife

  eLife assessment

  This study provides useful findings on how phonetic properties of words, i.e., their difficulty and prior knowledge, influence the outcome of targeted memory reactivation (TMR) during sleep. While these findings are supported by solid evidence, they are based on a small sample size warranting future work to shed further light on the impact of TMR in language learning.

Reviewed by eLife

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

1. Guoqiang Wang
2. Ryan J Guasp
3. Sangeena Salam
4. Edward Chuang
5. Andrés Morera
6. Anna J Smart
7. David Jimenez
8. Sahana Shekhar
9. Emily Friedman
10. Ilija Melentijevic
11. Ken C Nguyen
12. David H Hall
13. Barth D Grant
14. Monica Driscoll

• Curated by eLife

  eLife assessment

  This important study explores the potential influence of physiologically relevant mechanical forces on the extrusion of vesicles from C. elegans neurons. The authors provide compelling evidence to support the idea that uterine distension per se can induce vesicular extrusion from adjacent neurons. Overall, this work will be of interest to neuroscientists and investigators in the extracellular vesicle and proteostasis fields.

Reviewed by eLife

Analysis of fast calcium dynamics of honey bee olfactory coding

1. Marco Paoli
2. Antoine Wystrach
3. Brice Ronsin
4. Martin Giurfa

• Curated by eLife

  eLife assessment

  How neural circuits represent sensory signals during and after stimulus presentation is a central question in neuroscience. Here, a model of the insect mushroom body, constructed from simple, known synaptic connectivity rules, is shown to convincingly explain stimulus discrimination and associative memory, even in the presence of variability in the input signals as experimentally measured from the antennal lobe of the honeybee. This important study makes testable predictions for the role of specific neurons in a neural circuit for associative memory, of relevance to any study of neural network design and operation.

Reviewed by eLife

Speech-induced suppression and vocal feedback sensitivity in human cortex

1. Muge Ozker
2. Leyao Yu
3. Patricia Dugan
4. Werner Doyle
5. Daniel Friedman
6. Orrin Devinsky
7. Adeen Flinker

• Curated by eLife

  eLife assessment

  The manuscript describes human intracranial neural recordings in the auditory cortex during speech production, showing that the effects of delayed auditory feedback correlate with the degree of underlying speech-induced suppression. This is an important finding, as previous work has suggested that speech suppression and feedback sensitivity often do not co-localize and may be distinct processes, in contrast with findings in non-human primates where there is a strong correlation. The strength of the evidence is convincing, with appropriate experimental methods, data, and analysis.

Reviewed by eLife

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

1. Hyo Jun Kwon
2. Devi Santhosh
3. Zhen Huang

• Curated by eLife

  eLife assessment

  The study describes a link between beta-amyloid monomers, regulation of microglial activity and assembly of neocortex during development. It brings valuable findings that have theoretical and practical implications in the field of neuronal migration, neuronal ectopia and type II lissencephaly. Unfortunately, the evidence is incomplete and the manuscript would benefit from additional experiments to clarify the relationship between Ric8a and APP and bolster the findings.

Reviewed by eLife