Neuroscience

Sofosbuvir protects human brain organoids against SARS-CoV-2

1. Pinar Mesci
2. Angela Macia
3. Aurian Saleh
4. Laura Martin-Sancho
5. Xin Yin
6. Cedric Snethlage
7. Simoni Avansini
8. Sumit K. Chanda
9. Alysson Muotri

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

1. Laura Pellegrini
2. Anna Albecka
3. Donna L. Mallery
4. Max J. Kellner
5. David Paul
6. Andrew P. Carter
7. Leo C. James
8. Madeline A. Lancaster

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT, preLights

Working Memory Guides Perceptual Decisions Through Fast Capture and Slow Drift

1. Hyung-Bum Park
2. Weiwei Zhang

• Curated by eLife

  eLife Assessment

  This study provides important insights into how working memory shapes perceptual decisions, using a dual-task design, continuous mouse tracking, and hierarchical Bayesian modeling. By dissociating fast attentional capture effects from slower, sustained perceptual biases within single trials, the authors provide compelling evidence that working memory-perception interactions unfold through distinct dynamic processes rather than a single mechanism. This work will be of interest to researchers studying working memory, perception, decision-making, and mouse-tracking methodology.

Reviewed by eLife

Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval

1. Tamara Gedankien
2. Jennifer Kriegel
3. Erfan Zabeh
4. David McDonagh
5. Bradley Lega
6. Joshua Jacobs

• Curated by eLife

  eLife Assessment

  This fundamental work advances our understanding of the role of human hippocampal theta oscillations in memory encoding and retrieval. The evidence supporting the conclusions is convincing, using both scopolamine administration and intracranial EEG recordings. This work will be of broad interest to neuroscientists and has translational implications.

Reviewed by eLife

Mesoscale functional architecture in medial posterior parietal cortex

1. Riichiro Hira
2. Leah B Townsend
3. Ikuko T Smith
4. Che-Hang Yu
5. Jeffrey N Stirman
6. Yiyi Yu
7. Spencer LaVere Smith

• Curated by eLife

  eLife Assessment

  This fundamental study measures the functional specialization of distinct subregions within the mouse posterior parietal cortex (PPC) using mesoscopic two-photon calcium imaging during visual discrimination and choice history-dependent tasks. It presents compelling evidence supporting the existence of functional specialized subregions within the PPC. The work will be of interest to system and computational neuroscientists interested in decision-making, working memory, and multisensory integration.

Reviewed by eLife

The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

1. Tanay Ghosh
2. Roey Baror
3. Chao Zhao
4. Amar Sharma
5. Nick Goldman
6. Robin JM Franklin

• Curated by eLife

  eLife Assessment

  This valuable study demonstrates molecular changes associated with age related impairment in oligodendrocyte differentiation and ability to myelinate. The identification of particular genes that are associated with this decline will provide potential future targets for therapeutic interventions. The reviewers felt that the quality of the evidence was solid while identifying some minor weaknesses that if addressed would enhance the rigor of the study.

Reviewed by eLife

ELECTROPHYSIOLOGICAL CORRELATES OF CONSCIOUS EXPERIENCES DURING SLEEP: LUCID DREAMS, SLEEP PARALYSIS, OUT-OF-BODY EXPERIENCES, AND FALSE AWAKENINGS

1. Nerea L. Herrero
2. Yohann Corfdir
3. Aylin A. Vázquez-Chenlo
4. Lucila Capurro
5. Cecilia Forcato

Reviewed by preLights