Neuroscience

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

1. Pablo J. Lituma
2. Hyung-Bae Kwon
3. Karina Alviña
4. Rafael Lujan
5. Pablo E. Castillo

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to a larger neuroscience community as this is the first functional demonstration of presynaptic NMDA receptors at mossy fiber terminals in the hippocampus. NMDA receptors are generally known for being critically involved in learning & memory as coincidence detectors in Hebbian plasticity. Some studies, however, find NMDA receptors that function in more unconventional manners. The present paper provides strong evidence for the existence of such unconventional NMDA receptors at a specific subset of hippocampal mossy-fibre boutons. The combined use of electron microscopy, electrophysiological, optogenetic, calcium imaging, and genetic manipulation approaches expertly employed by the authors yields high quality compelling evidence in full support of the study's main conclusions. Overall, the investigation is well designed with a clear hypothesis, appropriate methodological considerations, and logical flow resulting in a well written manuscript that is sure to be of broad scientific interest.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

1. Marta Maltese
2. Jeffrey R. March
3. Alexander G. Bashaw
4. Nicolas X. Tritsch

• Curated by eLife

  Evaluation Summary:

  The paper is of broad interest to neuroscientists studying Parkinson's disease, dopamine (DA) modulation and striatum. The authors use a layered in vivo calcium imaging approach with cell-type reporters and universal GCaMP expression to simultaneously evaluate striatal projection neurons in the direct and indirect pathways (dSPNs, iSPNs) during basic locomotion. The authors report relationships between dSPN and iSPN ensemble sizes and DA pharmacology and dopamine depletion states. These results advance understanding of DA modulation and Parkinson's disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

1. Brandon Mark
2. Sen-Lin Lai
3. Aref Arzan Zarin
4. Laurina Manning
5. Ashok Litwin-Kumar
6. Albert Cardona
7. James W. Truman
8. Chris Q. Doe

• Curated by eLife

  Evaluation Summary:

  This paper sought to assess the relationship between developmental lineage and connectivity. It relies on detailed EM reconstructions and the knowledge of complete neuroblast lineages, thus correlating wiring with lineage. Through genetic manipulations of Notch function, it also correlates developmental programs with wiring. The conclusion is important and provides a well described cellular and genetic system for linking the developmental program of a cell to its connection specificity. It provides a framework for considering how to study these questions in other regions of the Drosophila brain and can be extended to the study of more complex mammalian systems where a similar neuroblast-lineage strategy generates different neuron types.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Impact of COVID-19 on Hospital Admission of Acute Stroke patients in Bangladesh

1. A T M Hasibul Hasan
2. Subir Chandra Das
3. Muhammad Sougatul Islam
4. Mohaimen Mansur
5. Md Shajedur Rahman Shawon
6. Rashedul Hassan
7. Mohammad Shah Jahirul Hoque Chowdhury
8. Md Badrul Alam Mondal
9. Quazi Deen Mohammad

Reviewed by ScreenIT

The S1 protein of SARS-CoV-2 crosses the blood-brain barrier: Kinetics, distribution, mechanisms, and influence of ApoE genotype, sex, and inflammation

1. Elizabeth M. Rhea
2. Aric F. Logsdon
3. Kim M. Hansen
4. Lindsey Williams
5. May Reed
6. Kristen Baumann
7. Sarah Holden
8. Jacob Raber
9. William A. Banks
10. Michelle A. Erickson

Reviewed by ScreenIT

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

1. Moheb Ghobrial
2. Jason Charish
3. Shigeki Takada
4. Taufik Valiante
5. Philippe P. Monnier
6. Ivan Radovanovic
7. Gary D. Bader
8. Thomas Wälchli

Reviewed by preLights, ScreenIT

Non-permissive SARS-CoV-2 infection in human neurospheres

1. Carolina da S.G. Pedrosa
2. Livia Goto-Silva
3. Jairo R. Temerozo
4. Leticia R.Q. Souza
5. Gabriela Vitória
6. Isis M. Ornelas
7. Karina Karmirian
8. Mayara A. Mendes
9. Ismael C. Gomes
10. Carolina Q. Sacramento
11. Natalia Fintelman-Rodrigues
12. Vinicius Cardoso Soares
13. Suelen da Silva Gomes Dias
14. José A. Salerno
15. Teresa Puig-Pijuan
16. Julia T. Oliveira
17. Luiz G.H.S. Aragão
18. Thayana C.Q. Torquato
19. Carla Veríssimo
20. Diogo Biagi
21. Estela M. Cruvinel
22. Rafael Dariolli
23. Daniel R. Furtado
24. Helena L. Borges
25. Patrícia T. Bozza
26. Stevens Rehen
27. Thiago Moreno L. Souza
28. Marília Zaluar P. Guimarães

Reviewed by ScreenIT

SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia

1. Olumayokun A. Olajide
2. Victoria U. Iwuanyanwu
3. Oyinkansola D. Adegbola
4. Alaa A. Al-Hindawi

Reviewed by ScreenIT

SARS-CoV-2 D614 and G614 spike variants impair neuronal synapses and exhibit differential fusion ability

1. Chiung-Ya Chen
2. Yu-Chi Chou
3. Yi-Ping Hsueh

Reviewed by ScreenIT

Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown

1. Tom Salomon
2. Adi Cohen
3. Daniel Barazany
4. Gal Ben-Zvi
5. Rotem Botvinik-Nezer
6. Rani Gera
7. Shiran Oren
8. Dana Roll
9. Gal Rozic
10. Anastasia Saliy
11. Niv Tik
12. Galia Tsarfati
13. Ido Tavor
14. Tom Schonberg
15. Yaniv Assaf

Reviewed by ScreenIT