Neuroscience

Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

1. Joanna Mattis
2. Ala Somarowthu
3. Kevin M Goff
4. Evan Jiang
5. Jina Yom
6. Nathaniel Sotuyo
7. Laura M Mcgarry
8. Huijie Feng
9. Keisuke Kaneko
10. Ethan M Goldberg

• Curated by eLife

  Evaluation Summary:

  Dravet syndrome, a severe seizure disorder resulting from a sodium channel mutation, is widely thought to result from impaired synaptic inhibition. Here the authors present multi-level evidence that excess synaptic excitation in the dentate gyrus is a locus of pathology. These results provide new insight into pathological mechanisms in Dravet syndrome that will be of interest to a broad range of neuroscientists studying epilepsy, as well as the role of the hippocampus and synaptic alterations in neurological disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

1. Amicia D Elliott
2. Adama Berndt
3. Matthew Houpert
4. Snehashis Roy
5. Robert L Scott
6. Carson C Chow
7. Hari Shroff
8. Benjamin H White

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest of neuroscience and ethology, as it bridges the gap between traditional and computational ethology by performing high-resolution imaging of muscle activity as an indicator of motor neuron activity, enabling the identification and analysis of behavior with computer algorithms. It also revealed the role of hormones in shaping and modifying the nervous system and animal behavior. The authors' major claims are supported by the data collected from thoughtfully designed animal experiments and computational analysis, although a few results can be interpreted better.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Mice in a labyrinth: Rapid learning, sudden insight, and efficient exploration

1. Matthew Rosenberg
2. Tony Zhang
3. Pietro Perona
4. Markus Meister

• Curated by eLife

  Evaluation Summary:

  This study lays the groundwork for a new level of precision in understanding mouse navigation behaviour by studying complex decisions that approximate those made in the wild, but can nevertheless be analysed with mathematically precise tools. Several exciting observations are made about navigation strategy. The manuscript will therefore be of broad interest across behavioural neuroscience. However, in its current form, some questions remain about some of the major claims.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Dynamic dichotomy of accumbal population activity underlies cocaine sensitization

1. Ruud van Zessen
2. Yue Li
3. Lucile Marion-Poll
4. Nicolas Hulo
5. Jérôme Flakowski
6. Christian Lüscher

• Curated by eLife

  Evaluation Summary:

  This study could help shed light on mechanistic connections between latent infection by EBV with an age-dependent autoimmune condition, such as rheumatoid arthritis. The authors use two models: a murine model of rheumatoid arthritis (CIA), and a murine analog of human EBV: 𝜸HV68. The use of these two models allows the investigation of how latent viral infection exacerbates the autoimmune condition via the action of a special class of B cells: Age-associated B cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

1. John Darby Cole
2. Jacobo Sarabia del Castillo
3. Gabriele Gut
4. Daniel Gonzalez-Bohorquez
5. Lucas Pelkmans
6. Sebastian Jessberger

• Curated by eLife

  Evaluation Summary:

  The objective of this study is to develop a novel immunofluorescence technique allowing for the multiplexed analysis of protein targets. This 4i method is an important technical advance will be of great interest for the scientific community.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

1. Jacob G. McPherson
2. Maria F. Bandres

• Curated by eLife

  Evaluation Summary:

  This manuscript reports a study that sought evidence of patterned inter-areal activity in the spinal cord of anesthetized rats. This could be a very significant finding, with potentially important scientific and therapeutic implications. However, the Methods lacks some necessary details, and the Results raise substantial issues that need to be resolved. Until these gaps and uncertainties are resolved, it is not possible to evaluate the results and their implications with confidence. Substantial revisions are essential.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection

1. Rayan Khaddaj-Mallat
2. Natija Aldib
3. Anne-Sophie Paquette
4. Aymeric Ferreira
5. Sarah Lecordier
6. Maxime Bernard
7. Armen Saghatelyan
8. Ayman ElAli

Reviewed by ScreenIT

ACE2 expression in rat brain: implications for COVID-19 associated neurological manifestations

1. Vito S Hernández
2. Mario A Zetter
3. Enrique C. Guerra
4. Ileana Hernández-Araiza
5. Nikita Karuzin
6. Oscar R. Hernández-Pérez
7. Lee E Eiden
8. Limei Zhang

Reviewed by ScreenIT

A state space modeling approach to real-time phase estimation

1. Anirudh Wodeyar
2. Mark Schatza
3. Alik S Widge
4. Uri T Eden
5. Mark A Kramer

• Curated by eLife

  Evaluation Summary:

  Rhythmic activities play an important role in cognition and disease, and there is an increasing interest in real-time phase tracking for closed-loop applications. In this manuscript, a novel approach based on state-space modeling to estimate the phase of EEG and LFP signals in real-time is presented. Open code for distribution is readily available. The proposed model is novel, timely and makes a clear contribution to the methods base in the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Coding of chromatic spatial contrast by macaque V1 neurons

1. Abhishek De
2. Gregory D Horwitz

• Curated by eLife

  Evaluation Summary:

  This paper is of broad interest to psychologists, neuroscientists, and engineers who seek to understand how color information is represented in visual cortex. The experiments provide sharply focussed tests of how chromatic information is compared across different spatial locations by individual neurons in visual cortex. The experiments are sound and the results speak to fundamental principles of encoding.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife