Neuroscience

SARS-CoV-2 Infects Peripheral and Central Neurons Before Viremia, Facilitated by Neuropilin-1

1. Jonathan D. Joyce
2. Greyson A. Moore
3. Poorna Goswami
4. Telvin L. Harrell
5. Tina M. Taylor
6. Seth A. Hawks
7. Jillian C. Green
8. Mo Jia
9. Neeharika Yallayi
10. Emma H. Leslie
11. Nisha K. Duggal
12. Christopher K. Thompson
13. Andrea S. Bertke

Reviewed by ScreenIT

LabNet hardware control software for the Raspberry Pi

1. Alexej Schatz
2. York Winter

• Curated by eLife

  Evaluation Summary:

  LabNet is a C++ package for low-level networked control of hardware on the Raspberry Pi with two main goals: time-critical operations and ease of extensibility, both topics of great interest to experimental neurobiologists. While the authors do present some interesting benchmarks supporting the real-time performance of LabNet, there are important confounding factors that should be addressed in the interpretation of the results. There is surprisingly little mention on how easy the platform is to extend, but with future improvements in documentation, more examples, and hardware support, LabNet is likely to become a very useful tool for experimentalists who need low-latency control for behavioral experiments over the network.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

1. Maren Klingelhöfer-Jens
2. Mana R Ehlers
3. Manuel Kuhn
4. Vincent Keyaniyan
5. Tina B Lonsdorf

• Curated by eLife

  Evaluation Summary

  The authors comprehensively assess the measurement properties of behavioral (skin conductance and ratings) and fMRI measures of fear conditioning (acquisition and extinction) in a sample of 107 participants, with 71 providing retest measures at 6 months. Retest reliability was generally low, whereas internal-consistency reliability was generally high. At the group level, reliability and criterion validity were generally good. Most measurements proved sensitive to modality, processing, or statistical decisions. Results are framed within a larger discussion of the role of measurement properties in individual difference research and clinical translation and will serve as an important building block towards improvement in both these areas.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Human hippocampal responses to network intracranial stimulation vary with theta phase

1. Sarah M Lurie
2. James E Kragel
3. Stephan U Schuele
4. Joel L Voss

• Curated by eLife

  Evaluation Summary:

  This project has substantial potential for better explaining the physiological basis of how to best use electrical stimulation on the cortical surface to modulate the hippocampal memory system. This would be an important task translationally and practically because it could lead to methods for modulating activity in deep brain structures noninvasively. However, in its current form the paper has weaknesses that make the results hard to trust and interpret. In its current form, it is not clear if the data clearly support the paper's strong conclusions.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Cortical adaptation to sound reverberation

1. Aleksandar Z Ivanov
2. Andrew J King
3. Ben DB Willmore
4. Kerry MM Walker
5. Nicol S Harper

• Curated by eLife

  Evaluation Summary:

  This paper identifies a new adaptation phenomenon in the cortical representation of sound that could explain invariance of auditory perception to reverberations of sounds in the environment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Drosophila gustatory projections are segregated by taste modality and connectivity

1. Stefanie Engert
2. Gabriella R Sterne
3. Davi D Bock
4. Kristin Scott

• Curated by eLife

  Evaluation Summary:

  The authors reconstructed the axons of gustatory receptor neurons from the labellum in an EM volume of a whole adult Drosophila brain. The authors were able to correlate the EM data with light microscopic data in terms of the identity of neurons reconstructed, thus enabling the use of published functional data already available in terms of different taste modalities. This revealed that extensive synaptic connections are found between neurons of the same modality. This paper will be of interest to neuroscientists working in the field of circuits and behavior, especially feeding behavior.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking

1. Marshall A Dalton
2. Arkiev D'Souza
3. Jinglei Lv
4. Fernando Calamante

• Curated by eLife

  Evaluation Summary:

  The work presented herein presents a novel method to characterize hippocampal-cortical anatomical network connectivity. These important results have the potential to generate new hypotheses and influence future queries into the hippocampal-cortical system.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline

1. Daphne Chylinski
2. Maxime Van Egroo
3. Justinas Narbutas
4. Vincenzo Muto
5. Mohamed Ali Bahri
6. Christian Berthomier
7. Eric Salmon
8. Christine Bastin
9. Christophe Phillips
10. Fabienne Collette
11. Pierre Maquet
12. Julie Carrier
13. Jean-Marc Lina
14. Gilles Vandewalle

• Curated by eLife

  Evaluation Summary

  This paper is of interest to neuroscientists studying sleep, memory, and neurodegeneration. The authors found that an altered pattern of brain wave during NREM sleep, changes in the coupling of spindles and slow waves, correlates with amyloid burden and predicts memory decline over time in healthy older individuals. The results suggest that sleep brain waves may be a useful tool in identifying older adults at risk for future cognitive impairment in the earliest stage.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

1. Robin F Dard
2. Erwan Leprince
3. Julien Denis
4. Shrisha Rao Balappa
5. Dmitrii Suchkov
6. Richard Boyce
7. Catherine Lopez
8. Marie Giorgi-Kurz
9. Tom Szwagier
10. Théo Dumont
11. Hervé Rouault
12. Marat Minlebaev
13. Agnès Baude
14. Rosa Cossart
15. Michel A Picardo

• Curated by eLife

  Evaluation Summary:

  This study investigates hippocampal dynamics over the course of early postnatal development with respect to spontaneous movements. Pioneering in vivo imaging in the hippocampus of neonatal mice, the authors find evidence for an abrupt developmental transition in this neural activity at the end of the first postnatal week in rodents and contribute to the understanding of how cognitive functions could emerge from the immature brain.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Contribution of behavioural variability to representational drift

1. Sadra Sadeh
2. Claudia Clopath

• Curated by eLife

  Evaluation Summary:

  This work builds on rapidly accumulating evidence for the importance of measuring and accounting for behavior in neural data, and will be of interest to a broad neuroscience audience. Analyses of Allen Brain Atlas datasets show that sensory representations change and match up reliably with behavioral state. The manuscript's main conclusions are supported by the data and analyses and the work raises important questions about previous accounts of the sources of representational drift in sensory areas of the brain.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife