Neuroscience

NaV1.1 is essential for proprioceptive signaling and motor behaviors

1. Cyrrus M Espino
2. Cheyanne M Lewis
3. Serena Ortiz
4. Miloni S Dalal
5. Snigdha Garlapalli
6. Kaylee M Wells
7. Darik A O'Neil
8. Katherine A Wilkinson
9. Theanne N Griffith

• Curated by eLife

  Evaluation Summary:

  This study provides insight into the identity of the sodium channel controlling excitability in proprioceptors. Using pharmacology, gene KO, behavior, and histology, the authors show quite convincingly that NaV1.1 in sensory neurons is essential for normal motor behavior and contributes to proprioceptor excitability. The work has interesting implications for human subjects with inherited variants of Nav1.1.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location

1. Tooba Abbassi-Daloii
2. Salma el Abdellaoui
3. Lenard M Voortman
4. Thom TJ Veeger
5. Davy Cats
6. Hailiang Mei
7. Duncan E Meuffels
8. Ewoud van Arkel
9. Peter AC 't Hoen
10. Hermien E Kan
11. Vered Raz

• Curated by eLife

  Evaluation Summary:

  This extensive study dissects the different gene expression patterns in a large set of different human lower limb muscles. It is an extensive transcriptome study. Its potential importance is that it points out insights into their differing changes in particular muscle diseases associated with specific gene defects.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

1. Catalin Mitelut
2. Yongxu Zhang
3. Yuki Sekino
4. Jamie D Boyd
5. Federico Bollanos
6. Nicholas V Swindale
7. Greg Silasi
8. Shreya Saxena
9. Timothy H Murphy

• Curated by eLife

  Evaluation Summary:

  The neural correlates of voluntary action is one of the most intriguing questions in neuroscience, but studying it at laboratory settings is incredibly difficult. Here, the authors have used an impressive range of methods and analyses approaches in mice to investigate the neural activity preceding voluntary action in mice. Using widefield calcium imaging in mice to study volition is novel and welcome but the great strength of this paper is its wide range of analyses approaches. There remains a question to what extent the findings reveal specific properties of 'voluntary action,'.

  This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.

Reviewed by eLife

Low and high frequency intracranial neural signals match in the human associative cortex

1. Corentin Jacques
2. Jacques Jonas
3. Sophie Colnat-Coulbois
4. Louis Maillard
5. Bruno Rossion

• Curated by eLife

  Evaluation Summary:

  This paper can provide novel basic science insights into how brain responses at different frequencies signal sensory information. An analysis of intracranial recordings in 121 human participants shows that low-frequency local field potentials and high-frequency (>30 Hz) broadband activity in response to face stimuli have largely similar spatial, functional, and timing properties. However, it is essential to show that the two response types can be reliably disambiguated and to critically discuss the generalizability of the findings.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

1. Nevena Stajković
2. Yuanyuan Liu
3. Aleksandra Arsić
4. Ning Meng
5. Hang Lyu
6. Nan Zhang
7. Dirk Grimm
8. Holger Lerche
9. Ivana Nikić-Spiegel

Reviewed by Review Commons

Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb

1. Shawn D Burton
2. Audrey Brown
3. Thomas P Eiting
4. Isaac A Youngstrom
5. Thomas C Rust
6. Michael Schmuker
7. Matt Wachowiak

• Curated by eLife

  Evaluation Summary:

  This is an important paper querying odor responses in the olfactory bulb at low concentrations. Classical studies have revealed a 'combinatorial code' for odorant recognition, with individual odorants represented by combinations of broadly tuned and low-affinity olfactory receptors. Here, the authors perform a large-scale analysis of odor responses across glomeruli and surprisingly observe that odorant receptors instead generally display remarkably narrow tuning profiles.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Higher-order unimodal olfactory sensory preconditioning in Drosophila

1. Juan Martinez-Cervantes
2. Prachi Shah
3. Anna Phan
4. Isaac Cervantes-Sandoval

• Curated by eLife

  Evaluation Summary:

  This paper shows that Drosophila can perform olfactory unimodal sensory preconditioning, an example of higher-order conditioning that may guide behaviour through inferred value. This is of conceptual significance for the brain, behavioural, and to some extent, the social sciences, because it shows that a conditioned response to a stimulus can occur even when the stimulus itself was never paired with punishment, for example.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

1. Rachana Deven Somaiya
2. Katelyn Stebbins
3. Ellen C Gingrich
4. Hehuang Xie
5. John N Campbell
6. A Denise R Garcia
7. Michael A Fox

• Curated by eLife

  Evaluation Summary:

  This paper proposes a novel mechanism used by the visual system to recruit interneurons into the visual thalamus. The primary claims that retinal ganglion cell axons secrete Shh in the visual thalamus that induces FGF15 expression by astrocytes, that then attract interneurons are sound. Because Shh signaling, interneuron migration, and astrocyte functions are studied by a large number of neuroscientists this study will have a high impact on the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex

1. Jonas-Frederic Sauer
2. Marlene Bartos

• Curated by eLife

  Evaluation Summary:

  This manuscript investigates the consequences of Disrupted-in-schizophrenia-1 (Disc1) gene knock out in the medial prefrontal cortex (mPFC) of mice. This work marks a potentially significant contribution to elucidate cortical circuits alterations in this genetic model of schizophrenia. The main message is that communication between cortical pyramidal neurons and fast spiking interneurons is altered with consequence on cortical network activities. The data generally support the conclusions made but analyses of electrophysiological data should improve.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

A model of egocentric to allocentric understanding in mammalian brains

1. Benigno Uria
2. Borja Ibarz
3. Andrea Banino
4. Vinicius Zambaldi
5. Dharshan Kumaran
6. Demis Hassabis
7. Caswell Barry
8. Charles Blundell

• Curated by eLife

  Evaluation Summary:

  This paper presents an artificial neuronal network which, from action and visual inputs, develops representations of space comparable to those found in the navigational system of the brain. They show that the representations developed by this network can be used in novel environments and in a reinforcement learning task. This demonstration of representations in absolute coordinates from agent-centered information is a significant contribution to neuroscientists as well as machine learning.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife