Neuroscience

Emergence of time persistence in a data-driven neural network model

1. Sebastien Wolf
2. Guillaume Le Goc
3. Georges Debrégeas
4. Simona Cocco
5. Rémi Monasson

• Curated by eLife

  Evaluation Summary:

  The authors show that how high-dimensional neural signals can be reduced to low-dimensional models with variables that can be directly linked to behavior. The reduced model can account for long timescales of persistent activity that arise from transisions between metastable model states. The authors further show that the rate of these transitions is modulated by water temperature according to the classic Arrhenius law.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Inhibition of noradrenergic signalling in rodent orbitofrontal cortex impairs the updating of goal-directed actions

1. Juan Carlos Cerpa
2. Alessandro Piccin
3. Margot Dehove
4. Marina Lavigne
5. Eric J Kremer
6. Mathieu Wolff
7. Shauna L Parkes
8. Etienne Coutureau

• Curated by eLife

  Evaluation Summary:

  The capacity to flexibly modify our actions in order to seek goals relies upon specific brain regions and neurochemicals. Cerpa et al identify norepinephrine (but not dopamine) within the ventrolateral orbitofrontal cortex (OFC) as key to updating identity-specific action-outcome associations when environmental conditions change. These conclusions are relatively well supported by the data and will be of interest to behavioural neuroscientists studying the function of OFC or noradrenaline signalling, as well as researchers studying associative learning.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition

1. Chi Zhang
2. Ming-Wen Hu
3. Xue-Wei Wang
4. Xiang Cui
5. Jing Liu
6. Qian Huang
7. Xu Cao
8. Feng-Quan Zhou
9. Jiang Qian
10. Shao-Qiu He
11. Yun Guan

• Curated by eLife

  Evaluation Summary:

  This is an important paper that uses state of the art technology to address the underlying neurobiology of neuropathic pain, a topic of considerable translational relevance. The study describes changes in gene expression at a single cell resolution in somatosensory neurons following peripheral nerve injury. Bioinformatics analyses were employed to segregate neurons in sub-classes and to derive predictions on potential functions of regulated genes. While the work has considerable strengths, such as the single cell approach, there are also some weaknesses, including the fact that new gene candidates did not undergo functional analysis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

1. Ge Gao
2. Shuyu Guo
3. Quan Zhang
4. Hefei Zhang
5. Cuizhen Zhang
6. Gang Peng

• Curated by eLife

  Evaluation Summary:

  Mutations in MINAR2 causes deafness in human and mice. Loss of function of Minar2 in mice causes a reduction of stereocilia and subsequent hair cell degeneration but the underlying mechanism is unclear. This zebrafish study demonstrated that the Minar2 protein interacts with cholesterol and is localized to the stereocilia of hair cells. The loss of Minar2 reduces cholesterol enrichment in the stereocilia with concomitant accumulation in lysosomes. Thus, this study provides the mechanistic insight of Minar2 and the first glimpse at the importance of cholesterol homeostasis in hair cell function.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Spatiotemporal organisation of human sensorimotor beta burst activity

1. Catharina Zich
2. Andrew J Quinn
3. James J Bonaiuto
4. George O'Neill
5. Lydia C Mardell
6. Nick S Ward
7. Sven Bestmann

• Curated by eLife

  Evaluation Summary:

  The authors use high spatial resolution MEG in humans to link two important components (time - transient bursts, space - waves) of neural sensorimotor dynamics by investigating how transient beta bursts propagate in the brain. The authors find two directions of propagating waves during beta bursts. The work links two fundamental aspects of neural dynamics which may yield new insights into the origins of sensorimotor behavior, with wide appeal to neuroscientists and clinicians. The reviewers considered the methodological work largely sound, although concerns were raised by the reviewers to what extent the travelling waves correspond to underlying neural activity or reflect the generative nature of field potentials.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

The meningeal transcriptional response to traumatic brain injury and aging

1. Ashley C Bolte
2. Daniel A Shapiro
3. Arun B Dutta
4. Wei Feng Ma
5. Katherine R Bruch
6. Michael A Kovacs
7. Ana Royo Marco
8. Hannah E Ennerfelt
9. John R Lukens

• Curated by eLife

  Evaluation Summary:

  Identification of transcriptional phenotypes driven by TBI across meningeal immune cell subsets and the effect of aging on these responses is an important and not well-defined area in the field. Multiple complementary and high-end approaches are taken to demonstrate the long-lasting effects that TBI drives in the brain and support the main findings of the manuscript. This manuscript will be of interest to readers in the field(s) of neuroimmunology, aging, and traumatic brain injury.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics

1. Yuri Elias Rodrigues
2. Cezar M Tigaret
3. Hélène Marie
4. Cian O'Donnell
5. Romain Veltz

• Curated by eLife

  Evaluation Summary:

  This paper proposes a computational model that combines biologically detailed elements with more simplified components to provide a comprehensive model of synaptic plasticity. It includes the stochastic character of many of the biophysical processes and introduces a new way to readout the plasticity cascade. It is evaluated against impressively many published experimental studies of hippocampal plasticity. The paper should be of interest not only to computational neuroscience but also to the synaptic neuroscience community but will benefit from a clearer description of assumptions and weaknesses, and a clearer separation of the essential elements in this model from the less critical elements.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Brain atlas for glycoprotein hormone receptors at single-transcript level

1. Vitaly Ryu
2. Anisa Gumerova
3. Funda Korkmaz
4. Seong Su Kang
5. Pavel Katsel
6. Sari Miyashita
7. Hasni Kannangara
8. Liam Cullen
9. Pokman Chan
10. TanChun Kuo
11. Ashley Padilla
12. Farhath Sultana
13. Soleil A Wizman
14. Natan Kramskiy
15. Samir Zaidi
16. Se-Min Kim
17. Maria I New
18. Clifford J Rosen
19. Ki A Goosens
20. Tal Frolinger
21. Vahram Haroutunian
22. Keqiang Ye
23. Daria Lizneva
24. Terry F Davies
25. Tony Yuen
26. Mone Zaidi

• Curated by eLife

  Evaluation Summary:

  This paper will be very interesting to the large class of neuroscientists who study functional roles of glycoprotein hormone receptors in the central nervous system. It provides detailed tissue-selective gene and receptor distributions of the three anterior pituitary hormones, and thus likely facilitates further relevant studies by other scientists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity

1. Thijs L van der Plas
2. Jérôme Tubiana
3. Guillaume Le Goc
4. Geoffrey Migault
5. Michael Kunst
6. Herwig Baier
7. Volker Bormuth
8. Bernhard Englitz
9. Georges Debrégeas

Reviewed by Review Commons

Evolution of neural activity in circuits bridging sensory and abstract knowledge

1. Francesca Mastrogiuseppe
2. Naoki Hiratani
3. Peter Latham

• Curated by eLife

  Evaluation Summary:

  The findings of the paper are of interest to scientists studying the learning of abstract representations. It provides insights into how feedforward networks evolve during a process of learning to map stimuli onto abstract classes via gradient descent. The results are appealing and the analyses thorough. As well, the paper makes some experimental predictions. It could benefit from a deeper discussion on how the findings may generalize to biologically more realistic networks and tasks.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife