Neuroscience

Per-ischemic changes in penumbral blood supply and its microscopic distribution

1. Nina K. Iversen
2. Eugenio Gutierréz Jimenéz
3. Peter Mondrup Rasmussen
4. Hugo Angelys
5. Irene Klærke Mikkelsen
6. Tristan R. Hollyer
7. Leif Østergaard

• Curated by eLife

  eLife assessment

  This manuscript provides a useful characterization of penumbral microvascular flow disturbances over the first hours after ischemia onset in a rat model of middle cerebral artery occlusion. This work suggests that there are microscopic changes (including directionality of capillary blood flow and formation of capillary stalls) during the peri-ischemic timeframe but the data are incomplete and not sufficient to support the claims.

Reviewed by eLife

An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

1. Niraja Ramesh
2. Marc Escher
3. Oriane Turrel
4. Janine Lützkendorf
5. Tanja Matkovic
6. Fan Liu
7. Stephan J Sigrist

• Curated by eLife

  eLife assessment

  This paper addresses the important question of presynaptic homeostasis and convincingly demonstrates antagonistic interactions between Spinophilin and Syd-1 in this process. It also provides a useful hypothesis for the downstream mechanisms.

Reviewed by eLife

A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

1. Delphine Pinatel
2. Edouard Pearlstein
3. Giulia Bonetto
4. Laurence Goutebroze
5. Domna Karagogeos
6. Valérie Crepel
7. Catherine Faivre-Sarrailh

• Curated by eLife

  eLife assessment

  This important study identifies the functional consequence of myelination of interneuronal axons on circuit function by showing that 4.1B deletion leads to altered myelination in a subset of interneurons and altered intrinsic and synaptic physiological parameters. The authors' conclusions about how myelination of inhibitory axons affects physiological properties are based on solid evidence using a combination of imaging and electrophysiological approaches.

Reviewed by eLife

Flexible coding of time or distance in hippocampal cells

1. Shai Abramson
2. Benjamin J Kraus
3. John A White
4. Michael E Hasselmo
5. Dori Derdikman
6. Genela Morris

• Curated by eLife

  eLife assessment

  The manuscript by Abramson and colleagues is a new analysis of previously published data from experiments in which rats ran on a treadmill in either fixed-time or fixed-distance trials. The valuable results provide solid evidence to demonstrate that time and distance cells are more common in fixed-time and fixed-distance trials, respectively. These findings suggest that the hippocampus flexibly shifts between representing variables depending on their relevance.

Reviewed by eLife

A neural network model of hippocampal contributions to category learning

1. Jelena Sučević
2. Anna C Schapiro

• Curated by eLife

  Evaluation Summary:

  This paper will be of broad interest to researchers interested in learning, memory, and/or the hippocampus. It offers a neuroanatomically inspired model of the hippocampus that reconciles its well-known role in episodic memory with its more recently appreciated role in category learning and generalization. The computational simulations are well conducted and support the key conclusions regarding complementary roles of distinct hippocampal pathways for different forms of learning. There are concerns with differentiating the current work from prior reports and the apparent discrepancy between the proposed model and well-established findings of place and concept cell recordings in hippocampus, but thought that these issues could be potentially resolved with additional clarification.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

1. Léa Broca-Brisson
2. Rania Harati
3. Clémence Disdier
4. Orsolya Mozner
5. Romane Gaston-Breton
6. Auriane Maïza
7. Narciso Costa
8. Anne-Cécile Guyot
9. Balazs Sarkadi
10. Agota Apati
11. Matthew R Skelton
12. Lucie Madrange
13. Frank Yates
14. Jean Armengaud
15. Rifat Hamoudi
16. Aloïse Mabondzo

• Curated by eLife

  eLife assessment

  This is an important study highlighting how a single protein transporter dysfunction can significantly alter brain biochemistry, potentially playing a crucial role in the intellectual disability in creatine transporter deficiency (CTD) patients. The evidence is compelling that the new in vitro CTD model using CTD patient's brain organoid cultures will be widely applicable. Despite minor areas for further exploration, the study significantly enhances our understanding of CTD, offering potential therapeutic targets and a robust foundation for continued research in the field.

Reviewed by eLife

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

1. Shamsuddin A. Bhuiyan
2. Mengyi Xu
3. Lite Yang
4. Evangelia Semizoglou
5. Parth Bhatia
6. Katerina I. Pantaleo
7. Ivan Tochitsky
8. Aakanksha Jain
9. Burcu Erdogan
10. Steven Blair
11. Victor Cat
12. Juliet M. Mwirigi
13. Ishwarya Sankaranarayanan
14. Diana Tavares-Ferreira
15. Ursula Green
16. Lisa A. McIlvried
17. Bryan A. Copits
18. Zachariah Bertels
19. John S. Del Rosario
20. Allie J. Widman
21. Richard A. Slivicki
22. Jiwon Yi
23. Reza Sharif-Naeini
24. Clifford J. Woolf
25. Jochen K. Lennerz
26. Jessica L. Whited
27. Theodore J. Price
28. Robert W. Gereau IV
29. William Renthal

Reviewed by Arcadia Science

Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

1. Sydney M Bailes
2. Daniel EP Gomez
3. Beverly Setzer
4. Laura D Lewis

• Curated by eLife

  eLife assessment

  This manuscript addresses the important issue of hemodynamic response function (HRF) variability across brain areas and will be valuable to researchers who use fMRI and other types of functional imaging that rely on neurovascular coupling. Using simulations and experiments, the authors provide solid evidence that differences in the HRF can impact spectrum-based metrics such as ALFF and fALFF. A better understanding of the variability of the HRF is critical for the proper interpretation of activation onset times and of differences observed in clinical populations where both neural and vascular alterations can be expected.

Reviewed by eLife

Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

1. Ann-Kathrin Joechner
2. Michael A Hahn
3. Georg Gruber
4. Kerstin Hoedlmoser
5. Markus Werkle-Bergner

• Curated by eLife

  eLife assessment

  This is an important analysis of two sleep datasets in children and adolescents that contributes to our understanding of sleep spindle and slow oscillation dynamics during development and is expected to be of interest to interdisciplinary fields including development and sleep. The analyses are solid and adequately complex to capture the changes in sleep spindle to slow oscillation coupling between the age groups. However, the paper would be strengthened by performing the same analyses in an adult sample to sufficiently characterize the maturation of sleep spindles and their coupling to slow oscillations.

Reviewed by eLife

BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI

1. Alena U. Uus
2. Vanessa Kyriakopoulou
3. Antonios Makropoulos
4. Abi Fukami-Gartner
5. Daniel Cromb
6. Alice Davidson
7. Lucilio Cordero-Grande
8. Anthony N. Price
9. Irina Grigorescu
10. Logan Z. J. Williams
11. Emma C. Robinson
12. David Lloyd
13. Kuberan Pushparajah
14. Lisa Story
15. Jana Hutter
16. Serena J. Counsell
17. A. David Edwards
18. Mary A. Rutherford
19. Joseph V. Hajnal
20. Maria Deprez

• Curated by eLife

  eLife assessment

  This study proposes a deep learning-based segmentation pipeline of fetal brain MRI, with parcellation based on a newly implemented atlas. This represents an important contribution to the field of developmental neuroscience and pediatric neuroimaging, especially as the pipeline and atlas are publicly available. The evidence for the pipeline robustness and atlas relevance is convincing given the extensive validations provided and the very high-quality ground truth dataset. Although beyond the state of the art, the study would benefit from further comparisons with existing methods and additional evaluations of the framework generalizability according to image quality, subject age or brain abnormalities.

Reviewed by eLife