Neuroscience

Characterization of Identified Dopaminergic Neurons in the Mouse Forebrain and Midbrain

1. Maggy Yu Hei Lau
2. Sana Gadiwalla
3. Susan Jones
4. Elisa Galliano

Reviewed by preLights

Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

1. John A Gaynes
2. Samuel A Budoff
3. Michael J Grybko
4. Alon Poleg-Polsky

• Curated by eLife

  eLife assessment

  This important study uses a combination of computational modeling and glutamate imaging to show how a particular synaptic organization referred to as space-time wiring contributes minimally to a dendritic computation that occurs in the retina. The evidence supporting the claims of the authors is compelling, incorporating new findings regarding dynamic receptive field properties, an improvement over previous modeling and experimental results based on static visual stimuli. The work will be of interest to retinal neurobiologists and neurophysiologists interested in dendritic computations.

Reviewed by eLife

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

1. Lukas M Weber
2. Heena R Divecha
3. Matthew N Tran
4. Sang Ho Kwon
5. Abby Spangler
6. Kelsey D Montgomery
7. Madhavi Tippani
8. Rahul Bharadwaj
9. Joel E Kleinman
10. Stephanie C Page
11. Thomas M Hyde
12. Leonardo Collado-Torres
13. Kristen R Maynard
14. Keri Martinowich
15. Stephanie C Hicks

• Curated by eLife

  eLife assessment

  This is an important initial study of cell type and spatially resolved gene expression in and around the locus coeruleus, the primary source of the neuromodulator norepinephrine in the human brain. The data are generated with cutting-edge techniques, and the work lays the foundation for future descriptive and experimental approaches to understand the contribution of the locus coeruleus to healthy brain function and disease. The empirical support for the main conclusions is solid. This paper, and the associated web application, will be of great interest to neuroscientists working on arousal-based behaviors and neurological and neuropsychiatric phenotypes.

Reviewed by eLife

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

1. Andrew J. Crowther
2. Sakeen W. Kashem
3. Madison E. Jewell
4. Henry Le Chang
5. Mariela Rosa Casillas
6. Élora Midavaine
7. Sian Rodriguez
8. Joao M. Braz
9. Artur Kania
10. Allan I. Basbaum

Reviewed by Arcadia Science

RETRACTED: PAK3 downregulation induces cognitive impairment following cranial irradiation

1. Haksoo Lee
2. Hyunkoo Kang
3. Changjong Moon
4. BuHyun Youn

• Curated by eLife

  eLife assessment

  The study investigates the functional impact of cranial irradiation in mouse and proposes PAK3 as molecular element involved in radiation-induced cognitive decrement. The significance of the findings is useful for fields covering radiation, brain tumor and cognition. The strength of evidence is solid, although the referees expressed divergent views on the manuscript.

Reviewed by eLife

Bipartite left-right sided endocrine system: processing of contralateral effects of brain injury

1. Hiroyuki Watanabe
2. Yaromir Kobikov
3. Olga Nosova
4. Daniil Sarkisyan
5. Vladimir Galatenko
6. Liliana Carvalho
7. Gisela H. Maia
8. Nikolay Lukoyanov
9. Igor Lavrov
10. Mathias Hallberg
11. Jens Schouenborg
12. Mengliang Zhang
13. Georgy Bakalkin

Reviewed by Review Commons

The importance of individual beliefs in assessing treatment efficacy

1. Luisa Fassi
2. Shachar Hochman
3. Zafiris J Daskalakis
4. Daniel M Blumberger
5. Roi Cohen Kadosh

• Curated by eLife

  eLife assessment

  This is an important report that has implications for both the brain stimulation field and beyond. The strength of evidence provided is quite convincing. The major strength of this work is the recognize the importance of participant expectation in brain stimulation studies.

Reviewed by eLife

Developing forebrain synapses are uniquely vulnerable to sleep loss

1. Sean M. Gay
2. Elissavet Chartampila
3. Julia S. Lord
4. Sawyer Grizzard
5. Tekla Maisashvili
6. Michael Ye
7. Natalie K. Barker
8. Angie L. Mordant
9. C. Allie Mills
10. Laura E. Herring
11. Graham H. Diering

Reviewed by Arcadia Science

Myomatrix arrays for high-definition muscle recording

1. Bryce Chung
2. Muneeb Zia
3. Kyle A Thomas
4. Jonathan A Michaels
5. Amanda Jacob
6. Andrea Pack
7. Matthew J Williams
8. Kailash Nagapudi
9. Lay Heng Teng
10. Eduardo Arrambide
11. Logan Ouellette
12. Nicole Oey
13. Rhuna Gibbs
14. Philip Anschutz
15. Jiaao Lu
16. Yu Wu
17. Mehrdad Kashefi
18. Tomomichi Oya
19. Rhonda Kersten
20. Alice C Mosberger
21. Sean O'Connell
22. Runming Wang
23. Hugo Marques
24. Ana Rita Mendes
25. Constanze Lenschow
26. Gayathri Kondakath
27. Jeong Jun Kim
28. William Olson
29. Kiara N Quinn
30. Pierce Perkins
31. Graziana Gatto
32. Ayesha Thanawalla
33. Susan Coltman
34. Taegyo Kim
35. Trevor Smith
36. Ben Binder-Markey
37. Martin Zaback
38. Christopher K Thompson
39. Simon Giszter
40. Abigail Person
41. Martyn Goulding
42. Eiman Azim
43. Nitish Thakor
44. Daniel O'Connor
45. Barry Trimmer
46. Susana Q Lima
47. Megan R Carey
48. Chethan Pandarinath
49. Rui M Costa
50. J Andrew Pruszynski
51. Muhannad Bakir
52. Samuel J Sober

• Curated by eLife

  eLife assessment

  This important paper reports major technical advances for in vivo intramuscular electrical recording from multiple motor units in behaving animals. The paper includes compelling demonstrations of the efficacy of this new technique in multiple animal species. This new muscle recording method has the potential to provide new insight into a wide range of questions in motor neuroscience.

Reviewed by eLife

Boosting of neural circuit chaos at the onset of collective oscillations

1. Agostina Palmigiano
2. Rainer Engelken
3. Fred Wolf

• Curated by eLife

  eLife assessment

  This work provides a valuable characterization of the chaotic dynamics of high-dimensional spiking networks in the presence of internally generated oscillations due to synaptic delays or externally generated oscillations due to external input. The authors provide convincing analytical and numerical calculations to support their claims, however, the paper suffers from heavy mathematical jargon that reduces its impact. The paper could be revised to provide interpretations of the results so that it can be accessible to a broader neuroscience audience. In its current form, findings will be of interest mostly to researchers working at the interface between theoretical neuroscience, applied mathematics, and physics.

Reviewed by eLife