Neuroscience

Microglial TNFα controls synaptic GABAARs, sleep slow waves and memory consolidation

1. Maria Joana Pinto
2. Lucy Bizien
3. Julie M.J. Fabre
4. Nina Ðukanović
5. Valentin Lepetz
6. Fiona Henderson
7. Marine Pujol
8. Romain W. Sala
9. Thibault Tarpin
10. Daniela Popa
11. Antoine Triller
12. Clément Léna
13. Véronique Fabre
14. Alain Bessis

Reviewed by Review Commons

A comprehensive neuroanatomical survey of the Drosophila Lobula Plate Tangential Neurons with predictions for their optic flow sensitivity

1. Arthur Zhao
2. Aljoscha Nern
3. Sanna Koskela
4. Marisa Dreher
5. Mert Erginkaya
6. Connor W. Laughland
7. Henrique Ludwigh
8. Alex Thomson
9. Judith Hoeller
10. Ruchi Parekh
11. Sandro Romani
12. Davi D. Bock
13. Eugenia Chiappe
14. Michael B. Reiser

• Curated by eLife

  eLife assessment

  This important study presents the first comprehensive catalog of the large neurons that compute optic flow in any insect. The morphological reconstructions from volume electron microscopy of the large arbors of these neurons, the Lobula Plate Tangential Neurons, were followed by the examination of their spatial arrangement to estimate their individual receptive fields and predict their optimal motion sensitivity. This compelling, rigorous data set, which includes the synaptic connectivity of the neurons under study with major target neurons in the fly brain, establishes a foundation for future studies on visual processing on the basis of a known connectome plus genetic driver lines to manipulate its constituent neurons. It will be of interest beyond insect vision to those studying sensory processing and neural circuit function.

Reviewed by eLife