Neuroscience

Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

1. Sara Bitar
2. Timo Baumann
3. Christopher Weber
4. Majd Abusaada
5. Liliana Rojas-Charry
6. Patrick Ziegler
7. Thomas Schettgen
8. Isabella Eva Randerath
9. Vivek Venkataramani
10. Bernhard Michalke
11. Eva-Maria Hanschmann
12. Giuseppe Arena
13. Rejko Krueger
14. Li Zhang
15. Axel Methner

Reviewed by Review Commons

TRESK background potassium channel in MrgprA3 ⁺ pruriceptors regulates acute and chronic itch

1. Júlia Llimós-Aubach
2. Alba Andres-Bilbe
3. Anna Pujol-Coma
4. Irene Pallás
5. Josep Maria de Anta
6. Concepció Soler
7. Núria Comes
8. Gerard Callejo
9. Xavier Gasull

Reviewed by Arcadia Science

A thin-film optogenetic visual prosthesis

1. Eric B Knudsen
2. Kara Zappitelli
3. Jennifer Brown
4. Jonathan Reeder
5. Kevin Sean Smith
6. Marat Rostov
7. Jaebin Choi
8. Amy Rochford
9. Nate Slager
10. Satoru K Miura
11. Kyle Rodgers
12. Ansel Reed
13. Yonatan R Lewis Israeli
14. Seton Shiraga
15. Kyung Jin Seo
16. Corey Wolin
17. Paul Dawson
18. Mohamed Eltaeb
19. Arvind Dasgupta
20. Max Rothman
21. Eugene Yoon
22. Paul Chong
23. Seleipiri Charles
24. Jay M. Stewart
25. Ruwan A Silva
26. Tyson Kim
27. Yifan Kong
28. Alan R Mardinly
29. Max Hodak

Reviewed by Arcadia Science

A new look at the architecture and dynamics of the Hydra nerve net

1. Athina Keramidioti
2. Sandra Schneid
3. Christina Busse
4. Christoph Cramer von Laue
5. Bianca Bertulat
6. Willi Salvenmoser
7. Martin Hess
8. Olga Alexandrova
9. Kristine M Glauber
10. Robert E Steele
11. Bert Hobmayer
12. Thomas W Holstein
13. Charles N David

• Curated by eLife

  eLife assessment

  This work presents important findings on the cellular and ultrastructural organization of the nervous system in the freshwater polyp Hydra. The authors present outstanding imaging data with convincing evidence to support their claims. The manuscript provides a starting point for further functional in vivo studies. The work will be of interest to developmental biologists and neurobiologists.

Reviewed by eLife

Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

1. Sachiko Haga-Yamanaka
2. Rogelio Nunez-Flores
3. Christi A Scott
4. Sarah Perry
5. Stephanie Turner Chen
6. Crystal Pontrello
7. Meera G Nair
8. Anandasankar Ray

• Curated by eLife

  eLife assessment

  This interesting and important work shows that diacety, a volatile organic compound released by yeast in fermenting fruit, can act as a histone deacetylase (HDAC) inhibitor and trigger wide changes in gene expression, together with suppression neurotoxicity in a Drosophila model of Huntington's disease. While the effects on gene expression changes and degenerative phenotypes are convincingly shown, further studies are required to determine whether and how olfactory sensory neurons and odorant receptors mediate the effects of diacetyl described by the authors.

Reviewed by eLife

Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling

1. Yuval Orsher
2. Ariel Rom
3. Rotem Perel
4. Yoav Lahini
5. Pablo Blinder
6. Mark Shein-Idelson

• Curated by eLife

  eLife assessment

  In this important work, authors show that brain activity thought to be a travelling wave may just be a series of sequentially activated sources at the neuron spiking level. They support this with convincing results from a turtle cortex preparation and relevant simulations. This work will be of interest to neuroscientists interested in understanding how cortical computations are made.

Reviewed by eLife

The LH receptor regulates hippocampal spatial memory and restores dendritic spine density in ovariectomized APP/PS1 AD mice

1. Megan Mey
2. Sabina Bhatta
3. Sneha Suresh
4. Luis Montero Labrador
5. Helen Piontkivska
6. Gemma Casadesus

Reviewed by Arcadia Science

Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells

1. Smrithi Prem
2. Bharati Dev
3. Cynthia Peng
4. Monal Mehta
5. Rohan Alibutud
6. Robert J Connacher
7. Madeline St Thomas
8. Xiaofeng Zhou
9. Paul Matteson
10. Jinchuan Xing
11. James H Millonig
12. Emanuel DiCicco-Bloom

• Curated by eLife

  eLife assessment:

  This important study describes converging cellular phenotypes in human neural progenitor cells derived from individuals with differing genetic forms of autism spectrum disorders. These convincing data demonstrate that altered mTOR signaling occurs in all cases of autism examined in the study, providing a common starting point for understanding the etiology of neuronal deficits in autism. The work will be of broad interest to neurobiologists especially those studying molecular mechanisms of brain development and disease.

Reviewed by eLife

Multiple objects evoke fluctuating responses in several regions of the visual pathway

1. Meredith N Schmehl
2. Valeria C Caruso
3. Yunran Chen
4. Na Young Jun
5. Shawn M Willett
6. Jeff T Mohl
7. Douglas A Ruff
8. Marlene Cohen
9. Akinori F Ebihara
10. Winrich A Freiwald
11. Surya T Tokdar
12. Jennifer M Groh

• Curated by eLife

  eLife assessment

  This important study adds to the growing body of evidence that neural responses fluctuate in time to alternatively represent one among multiple concurrent stimuli and that these fluctuations seize when objects fuse into one perceived object. The present study provides solid evidence from multiple brain areas and stimuli types to support this hypothesis. Overall, the study illustrates how the brain can use time dimension and synchrony to either parse or integrate stimuli into a coherent representation.

Reviewed by eLife

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

1. Andrew S Blaeser
2. Jun Zhao
3. Arthur U Sugden
4. Simone Carneiro-Nascimento
5. Mark L Andermann
6. Dan Levy

• Curated by eLife

  eLife assessment

  This fundamental study explored the impact of migraine-related cortical spreading depression (CSD) on the firing of nerves innervating the coverings of the brain that are considered the putative source of migraine-related pain. Using convincing approaches they show that these responses are altered in response to mechanical deformation of the brain coverings. Given that migraine is characterized by worsening head pain in response to movement, the findings offer a potential mechanism that may explain this clinical phenomenon.

Reviewed by eLife