Neuroscience

Theta cycle dynamics of spatial representations in the lateral septum

1. Katarzyna Bzymek
2. Fabian Kloosterman

• Curated by eLife

  eLife assessment

  In this study, the authors present convincing evidence to demonstrate theta cycle skipping by individual neurons of the lateral septum, which they then relate to population coding of future trajectories encapsulated by theta cycles. This valuable finding furthers our understanding of how the septum conveys navigational information downstream.

Reviewed by eLife

Conservation of Neuron‐Astrocyte Correlated Activity in Developing Sensory Pathways

1. Vered Kellner
2. Patrick Parker
3. Dongeun Heo
4. Xuelong Mi
5. Mikhail Coen
6. Guoqiang Yu
7. Gesine Saher
8. Loyal A. Goff
9. Dwight E. Bergles

Reviewed by Arcadia Science

EFEMP1 contributes to light-dependent ocular growth in zebrafish

1. Jiaheng Xie
2. Bang V. Bui
3. Patrick T. Goodbourn
4. Patricia R. Jusuf

Reviewed by Review Commons

Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

1. Daniel Chen
2. Polyxeni Philippidou
3. Bianca de Freitas Brenha
4. Ashleigh E. Schaffer
5. Helen C. Miranda

• Curated by eLife

  eLife assessment

  This is an important study describing a neuromuscular junction co-culture system using human cells that the authors use to study the synaptic consequences of ALS mutations. The data supporting the system are solid and show the value of using myotubes and motor neurons from the same donor. The study will be of interest to researchers who model neuromuscular junction disorders, however, the authors could more comprehensively compare and contrast their system with previous literature describing other similar models. There are also technical weaknesses that limit the interpretation of specific findings.

Reviewed by eLife