Neuroscience

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradation

1. Shiping Zhang
2. Linfang Wang
3. Shuanglong Yi
4. Yu-ting Tsai
5. Honglei Wang
6. Shuhua Li
7. Ruiqi Wang
8. Yang Liu
9. Wei Yan
10. Chang Liu
11. Kai-Wen He
12. Margaret S. Ho

Reviewed by PREreview

A multiscale model of striatum microcircuit dynamics

1. Federico Tesler
2. Alexander Kozlov
3. Sten Grillner
4. Alain Destexhe

• Curated by eLife

  eLife assessment

  This study is potentially valuable, however currently its findings are incomplete, in that the paper's promise to deliver multiscale models that further our understanding of striatal function remains largely unfulfilled. A major weakness is that the findings are not integrated well within the rich landscape of existing striatal network modeling literature. Another major weakness is that the model is explored only in overly simplified scenarios and with limited comparison to data.

Reviewed by eLife

Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats

1. Eun Joo Kim
2. Mi-Seon Kong
3. Sanggeon Park
4. Jeiwon Cho
5. Jeansok John Kim

• Curated by eLife

  eLife assessment

  This study presents valuable findings describing how the midbrain periaqueductal gray matter and basolateral amygdala communicate when a predator threat is detected. Though the periaqueductal gray is usually viewed as a downstream effector, this work contributes to a growing body of literature from this lab showing that the periaqueductal gray produces effects by acting on the basolateral amygdala, the experimental design, data collection and analysis methods provide solid evidence for the main claims. The anatomical and immediately early gene evidence that the paraventricular nucleus of the thalamus may serve as a mediator of dorsolateral periaqueductal gray to basolateral amygdala neurotransmission provides and impetus for future functional assessment of this possibility. This study will appeal to a broad audience, including basic scientists interested in neural circuits, basic and clinical researchers interested in fear, and behavioral ecologists interested in foraging.

Reviewed by eLife

Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain

1. Deepanshu N. D. Singh
2. Abigail R. E. Roberts
3. Xiaocui Wang
4. Guiyi Li
5. Enrique Quesada Moraga
6. David Alliband
7. Elizabeth Ballou
8. Hung-Ji Tsai
9. Alicia Hidalgo

Reviewed by Review Commons

Neural population dynamics underlying evidence accumulation in multiple rat brain regions

1. Brian DePasquale
2. Carlos D Brody
3. Jonathan W Pillow

• Curated by eLife

  eLife assessment

  This valuable paper presents findings showing that different brain regions were best described by a distinct accumulation model, which all differed from the model that best described the rat's choices. These findings are solid because the authors present a very strong methodological approach. This work will be of interest to a wide neuroscientific audience.

Reviewed by eLife

Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

1. Katrin Franke
2. Chenchen Cai
3. Kayla Ponder
4. Jiakun Fu
5. Sacha Sokoloski
6. Philipp Berens
7. Andreas Savas Tolias

• Curated by eLife

  eLife assessment

  Franke et al. explore and characterize color response properties of neurons in mouse primary visual cortex (V1), revealing specific color opponent encoding strategies across the visual field. The paper provides evidence for the existence of color opponency in a subset of neurons within V1 and shows that these color opponent neurons are more numerous in the upper visual field. Support for the main conclusions is convincing and the dataset that forms the basis of the paper is impressive. The paper will make an important contribution to understanding how color is coded in mouse V1.

Reviewed by eLife

Future movement plans interact in sequential arm movements

1. Mehrdad Kashefi
2. Sasha Reschechtko
3. Giacomo Ariani
4. Mahdiyar Shahbazi
5. Alice Tan
6. Jörn Diedrichsen
7. J Andrew Pruszynski

• Curated by eLife

  eLife assessment

  This study presents an important set of results illuminating how movement sequences are planned. Using several different behavioural manipulations and analysis methods, the authors present compelling evidence that multiple future movements are planned simultaneously with execution, and that these future movement plans influence each other. The work will be of great interest to those studying motor control.

Reviewed by eLife

Is ChatGPT detrimental to innovation? A field experiment among university students

1. Mazen Hassan
2. Engi Amin
3. Sarah Mansour
4. Zeyad Kelani

Reviewed by PREreview

Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

1. Srdjan Sumarac
2. Kiah A Spencer
3. Leon A Steiner
4. Conor Fearon
5. Emily A Haniff
6. Andrea A Kühn
7. Mojgan Hodaie
8. Suneil K Kalia
9. Andres Lozano
10. Alfonso Fasano
11. William Duncan Hutchison
12. Luka Milosevic

• Curated by eLife

  eLife assessment

  This manuscript is a valuable study of the responses of GPi neurons to deep brain stimulation (DBS) in human Parkinson disease and dystonia patients and it finds convincing evidence for altered short-term and long-term plasticity in response to DBS between the two patient populations. This dataset is of interest to both basic and clinical researchers working in the field of DBS and movement disorders.

Reviewed by eLife

Difficulty in artificial word learning impacts targeted memory reactivation and its underlying neural signatures

1. Arndt-Lukas Klaassen
2. Björn Rasch

• Curated by eLife

  eLife assessment

  This study provides useful findings on how phonetic properties of words, i.e., their difficulty and prior knowledge, influence the outcome of targeted memory reactivation (TMR) during sleep. While these findings are supported by solid evidence, they are based on a small sample size warranting future work to shed further light on the impact of TMR in language learning.

Reviewed by eLife