Neuroscience

Mitochondrial calcium modulates odor-mediated behavioral plasticity in Caenorhabditis elegans

1. Hee Kyung Lee
2. Abe Gayle Santos
3. Kyu-Sang Park
4. Kyoung-hye Yoon

• Curated by eLife

  eLife Assessment

  This study presents important findings that will allow for a better understanding of the role of mitochondria in behaviours of C. elegans. There is convincing evidence that mutants in a subunit of the mitochondrial calcium uniporter (MCU-1) show defects in olfactory adaptation and this gene regulates neuropeptide secretion and allows for behavioural modulation in C. elegans. However, the evidence that mitochondrial calcium modulates odour-based behaviour in C. elegans is incomplete. This claim would require support from calcium imaging in conditioned WT and mcu-1 animals. This work would be of interest to labs working on behaviours across phyla.

Reviewed by eLife

Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

1. Jihoon Kim
2. Jean G Rosario
3. Eric Mendoza
4. Da Kuang
5. Junhyong Kim

• Curated by eLife

  eLife Assessment

  This useful study combines multiplexed RNA-FISH with downstream analyses and modelling to describe novel dendritic mRNA distribution and behavioural features. Although the downstream analysis pipeline is novel, the results from this study are as of yet incomplete. Further inclusion of key missing controls, further work to better assess the physiological relevance, or additional modelling to expand their conclusions would make this work of greater interest to RNA biologists.

Reviewed by eLife

Engineering Microglial Cells to Promote Spinal Cord Injury Recovery

1. Qingsheng Zhou
2. Jianchao Liu
3. Qiongxuan Fang
4. Chunming Zhang
5. Wei Liu
6. Yifeng Sun

• Curated by eLife

  eLife Assessment

  The study is useful for advancing understanding of spinal cord injuries, but it presents inadequate evidence due to the use of multiple datasets. Data were collected from different models of spinal cord injury, various regions of the spinal cord, and an iPSC model, with the differences between these models making it difficult to draw reliable conclusions.

Reviewed by eLife

Unveiling the functional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing

1. L. Zonca
2. F. C. Bellier
3. G. Milior
4. P. Aymard
5. J. Visser
6. A. Rancillac
7. N. Rouach
8. D. Holcman

Reviewed by Arcadia Science