Neuroscience

Attention modulates human visual responses to objects by tuning sharpening

1. Narges Doostani
2. Gholam-Ali Hossein-Zadeh
3. Radoslaw M Cichy
4. Maryam Vaziri-Pashkam

• Curated by eLife

  eLife Assessment

  This valuable study has the potential to shed mechanistic light on how attention mechanisms that influence competition between multiple visual stimuli are modulated by the relative neural similarity of these stimuli. The study provides convincing data that will also be used for future modeling efforts. The study will be of interest to researchers working on the neural basis of visual attention.

Reviewed by eLife

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

1. Preethi Somasundaram
2. Madeline M Farley
3. Melissa A Rudy
4. Katya Sigal
5. Andoni I Asencor
6. David G Stefanoff
7. Malay Shah
8. Puneetha Goli
9. Jenny Heo
10. Shufang Wang
11. Nicholas M Tran
12. Trent A Watkins

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding about the role of Perk (Protein kinase RNA-like endoplasmic reticulum kinase) and Atf4 (Activating Transcription Factor-4) in the integrated neurodegenerative and regenerative responses following the optic nerve injury. The authors present solid evidence, combining newly generated transcriptomic data with publicly available datasets to strengthen their findings. Despite some limitations in data quality and interpretation, the study is likely to be of interest to researchers studying optic neuropathies and axonal regeneration.

Reviewed by eLife

Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans

1. Qi Jia
2. Drew Young
3. Qixin Zhang
4. Derek Sieburth

• Curated by eLife

  eLife Assessment

  This study presents convincing evidence of the role of an intestine-released neuropeptide, FLP-2, in the oxidative stress response of C. elegans, as well as for the neural circuit pathway that regulates its release in response to sensing reactive oxygen species (i.e., H2O2). These valuable results advance the understanding of gut-brain signaling and the neural circuit basis of behavioral responses to stress.

Reviewed by eLife

Parvalbumin interneuron ErbB4 controls ongoing network oscillations and olfactory behaviors in mice

1. Bin Hu
2. Chi Geng
3. Feng Guo
4. Ying Liu
5. Ran Wang
6. You-Ting Chen
7. Xiao-Yu Hou

• Curated by eLife

  eLife Assessment

  This study provides useful information on the potential role of ERbB4 expression in parvalbumin-positive cells on olfactory behaviour and circuit dynamics in the olfactory bulb. The question is timely and novel, and findings could shed light on the critical role that ErbB4 may play in modulating olfactory bulb cell function and olfactory perception. Although the authors use a comprehensive set of experiments for their analysis, the evidence is incomplete as many of the experiments are underpowered and the model for selective knockout of ErbB4 in olfactory parvalbumin cells is not validated.

Reviewed by eLife

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

1. William Hockeimer
2. Ruo-Yah Lai
3. Maanasa Natrajan
4. William Snider
5. James J Knierim

• Curated by eLife

  eLife Assessment

  This is a valuable work that convincingly reveals that place cells in the hippocampus that exhibit repeated firing fields incorporate information about non-positional variables in each firing field. They reveal that individual firing fields of a single place cell can exhibit tuning to different head orientations, suggesting hippocampal neurons are flexible in terms of how they incorporate non-positional inputs.

Reviewed by eLife

Oral Administration of Boldine Reduces Spare Nerve Injury-Induced Neuropathic Pain

1. Jiangping Pan
2. Carlos A. Toro
3. Christine Chow
4. Yorley Duarte
5. Juan C. Sáez
6. Christopher P. Cardozo
7. Wei Zhao

Reviewed by Arcadia Science

Adaptive Integration of Perceptual and Reward Information in an Uncertain World

1. Prashanti Ganesh
2. Radoslaw M Cichy
3. Nicolas W Schuck
4. Carsten Finke
5. Rasmus Bruckner

• Curated by eLife

  eLife Assessment

  This valuable study by Ganesh and colleagues examined how both the value and salience of sensory information can affect economic decision-making. The results provide insights into how different sources of uncertainty found in the real world, including those related to the perception of objects and those related to values associated with objects, can together influence decision-making behavior in systematic ways. The evidence is solid but overlaps with previous studies and could be improved by clarifying novelty and experimental details and considering additional models.

Reviewed by eLife

Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

1. Toshiki Kobayashi
2. Daichi Nozaki

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on how the sensorimotor control system deals with redundancy within our body, based on a novel bimanual task. The evidence supporting the authors' claims is convincing, as demonstrated over four different experiments. The work will be of interest to researchers from the motor control community and related fields, and further investigation into the interpretation of the findings could increase the generalisation of the study to a broader audience.

Reviewed by eLife

Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with spinal cord hemisection

1. Elena Massai
2. Marco Bonizzato
3. Isley De Jesus
4. Roxanne Drainville
5. Marina Martinez

• Curated by eLife

  eLife Assessment

  The contributions of ipsilateral cortical pathways to motor control are yet not fully understood. Here, the authors present important insights into their role in locomotion following unilateral spinal cord injury. Their data provide convincing evidence in rats that stimulation of ipsilateral motor cortex improves the injured side's ability to support weight and leads to improved locomotion, a result that may inspire new treatments for spinal or cerebral injuries.

Reviewed by eLife

Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

1. Max Henry Hills
2. Limei Ma
3. Ai Fang
4. Thelma Chiremba
5. Seth Malloy
6. Allison R Scott
7. Anoja G Perera
8. C Ron Yu

• Curated by eLife

  eLife Assessment

  The manuscript by Hills, et al. presents data that support multiple conclusions regarding the gene expression patterns of cells, especially chemosensory neurons. The evidence is largely solid, with transcriptomic analysis combined and validated by spatially resolved expression in tissue sections, but is incomplete in other ways with some claims not fully supported. This large-scale single-cell transcriptomics dataset is an important resource, alongside a thorough exploration of the molecular features of the different cell types within the mouse vomeronasal organ, including expression of chemosensory receptors.

Reviewed by eLife