Microbiology

Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L

1. Fei Yu
2. Ting Pan
3. Feng Huang
4. Ruosu Ying
5. Jun Liu
6. Huimin Fan
7. Junsong Zhang
8. Weiwei Liu
9. Yingtong Lin
10. Yaochang Yuan
11. Tao Yang
12. Rong Li
13. Xu Zhang
14. Xi Lv
15. Qianyu Chen
16. Anqi Liang
17. Fan Zou
18. Bingfeng Liu
19. Fengyu Hu
20. Xiaoping Tang
21. Linghua Li
22. Kai Deng
23. Xin He
24. Hui Zhang
25. Yiwen Zhang
26. Xiancai Ma

Reviewed by ScreenIT

The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS

1. Tong Meng
2. Hao Cao
3. Hao Zhang
4. Zijian Kang
5. Da Xu
6. Haiyi Gong
7. Jing Wang
8. Zifu Li
9. Xingang Cui
10. Huji Xu
11. Haifeng Wei
12. Xiuwu Pan
13. Rongrong Zhu
14. Jianru Xiao
15. Wang Zhou
16. Liming Cheng
17. Jianmin Liu

Reviewed by ScreenIT

Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model

1. Bo Ram Beck
2. Bonggun Shin
3. Yoonjung Choi
4. Sungsoo Park
5. Keunsoo Kang

Reviewed by ScreenIT

DnaK duplicates and regionally evolves for the increase of proteomic complexity in bacteria

1. Zhuo Pan
2. Li Zhuo
3. Tian-yu Wan
4. Rui-yun Chen
5. Yue-zhong Li

Reviewed by Review Commons

Deep learning image analysis for filamentous fungi taxonomic classification: Dealing with small datasets with class imbalance and hierarchical grouping

1. Stefan Stiller
2. Juan F Dueñas
3. Stefan Hempel
4. Matthias C Rillig
5. Masahiro Ryo

Reviewed by Arcadia Science

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

1. C.R. Plumlee
2. H.W. Barrett
3. D.E. Shao
4. K.A. Lien
5. L.M. Cross
6. S.B. Cohen
7. P.T Edlefsen
8. K.B. Urdahl

Reviewed by Review Commons

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

1. Hsiao-Fan Chen
2. Wei-Jan Wang
3. Chung-Yu Chen
4. Wei-Chao Chang
5. Po-Ren Hsueh
6. Shin-Lei Peng
7. Chen-Shiou Wu
8. Yeh Chen
9. Hsin-Yu Huang
10. Wan-Jou Shen
11. Shao-Chun Wang
12. Mien-Chie Hung

• Curated by eLife

  eLife assessment

  This fundamental work provides preclinical evidence to support that natural tannins derived from grapeseed can inhibit or prevent infection by the SARS-CoV-2 viruses. The evidence provided is mostly solid to convincing and supports the conclusions. This work will be of broad interest to cell biologists and physicians.

Reviewed by eLife

Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

1. Alexander Lobanov
2. Samantha Dyckman
3. Helen Kurkjian
4. Babak Momeni

• Curated by eLife

  eLife assessment

  This important study uses computational simulations to explore how spatial structure can affect the coexistence between different microbial species, ultimately helping to explain diversity in microbial communities. The evidence supporting the conclusions is solid, although the parameter values used in the simulations were deemed to be unrealistic. Further investigation on whether the conclusions would hold under more realistic assumptions would be very interesting to microbial ecologists quite broadly.

Reviewed by eLife

Enterococcus faecalis strains with compromised CRISPR-Cas defense emerge under antibiotic selection for a CRISPR-targeted plasmid

1. Wenwen Huo
2. Valerie J. Price
3. Ardalan Sharifi
4. Michael Q. Zhang
5. Kelli L. Palmer

Reviewed by Arcadia Science

Bioactive exometabolites drive maintenance competition in simple bacterial communities

1. John L. Chodkowski
2. Ashley Shade

Reviewed by Arcadia Science