Microbiology

Mechanical compression induces persistent bacterial growth during bacteriophage predation

1. Guy Mason
2. Enrique R. Rojas

Reviewed by Arcadia Science

Sporulation activated via σ ^W protects Bacillus from a Tse1 peptidoglycan hydrolase T6SS effector

1. Alicia I. Pérez-Lorente
2. Carlos Molina-Santiago
3. Antonio de Vicente
4. Diego Romero

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of microbiology, particularly those interested in bacterial interactions, secretion systems, and stress responses. It identifies the molecules and mechanisms that explain a competitive interaction between two soil-dwelling bacterial species. The data support most of the conclusions of the manuscript, but some controls are lacking and some of the interpretations are not fully justified by the experiments shown.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Ferric reductase-related proteins mediate fungal heme acquisition

1. Udita Roy
2. Shir Yaish
3. Ziva Weissman
4. Mariel Pinsky
5. Sunanda Dey
6. Guy Horev
7. Daniel Kornitzer

• Curated by eLife

  Evaluation Summary:

  Iron acquisition is an essential problem for microbial growth and survival. Host defense mechanisms generally reduce iron availability and microbes often find themselves in iron poor environments. This study provides new insights into how the fungal pathogen Candida albicans obtains iron during infection.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

PfHDAC1 is an essential regulator of parasite asexual growth with its altered genomic occupancy and activity associated with artemisinin drug resistance in Plasmodium falciparum

1. Abhishek Kanyal
2. Heledd Davies
3. Bhagyashree Deshmukh
4. Dilsha Farheen
5. Moritz Treeck
6. Krishanpal Karmodiya

Reviewed by Review Commons

Chemical Links Between Redox Conditions and Estimated Community Proteomes from 16S rRNA and Reference Protein Sequences

1. Jeffrey M. Dick
2. Jingqiang Tan

• Curated by eLife

  Evaluation Summary:

  This study presents an in-depth analyses of carbon oxidation state and hydration state of proteomes in different taxa and environmental settings, which contributes to our understanding of how microbial communities are shaped by their surroundings. The study has merit, but there also some technical weaknesses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Legionella ‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling

1. Simone Vormittag
2. Dario Hüsler
3. Ina Haneburger
4. Tobias Kroniger
5. Aby Anand
6. Manuel Prantl
7. Caroline Barisch
8. Sandra Maaß
9. Dörte Becher
10. François Letourneur
11. Hubert Hilbi

Reviewed by Review Commons

Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System

1. Donghyun Park
2. Samuel Steiner
3. Meng Shao
4. Craig R. Roy
5. Jun Liu

• Curated by eLife

  Evaluation Summary:

  Park et al.'s work provides insight into the infection processes of the human pathogen Coxiella burnetii with unprecedented detail. Their time course of cellular infection reveals the timing of key events and detects a previously unrecognized membrane structure. This work will shed new insight into the infection process of this pathogen allowing new targets for the treatment of infection with Coxiella.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria

1. Kuldeepkumar R Gupta
2. Celena M Gwin
3. Kathryn C Rahlwes
4. Kyle J Biegas
5. Chunyan Wang
6. Jin Ho Park
7. Jun Liu
8. Benjamin M Swarts
9. Yasu S Morita
10. E Hesper Rego

• Curated by eLife

  Evaluation Summary:

  This manuscript tackles the important question of what proteins regulate asymmetrical cell division in Mycobacteria. This will be of interest to all individuals interested in bacterial physiology. The data are sound, but some of the conclusions need to be tempered or bolstered, in relation to the models proposed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress

1. Stephanie D. Nofal
2. Caia Dominicus
3. Malgorzata Broncel
4. Nicholas J. Katris
5. Helen R. Flynn
6. Gustavo Arrizabalaga
7. Cyrille Y. Botté
8. Brandon M. Invergo
9. Moritz Treeck

Reviewed by Review Commons

Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection

1. Anna-Lisa E. Lawrence
2. Ryan P. Berger
3. David R. Hill
4. Sha Huang
5. Veda K. Yadagiri
6. Brooke Bons
7. Courtney Fields
8. Gautam J. Sule
9. Jason S. Knight
10. Christiane E. Wobus
11. Jason R. Spence
12. Vincent B. Young
13. Mary X. O’Riordan
14. Basel H. Abuaita

Reviewed by Review Commons