Microbiology

  1. Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation

    1. Zhang Cheng
    2. Liu Cheng
    3. Jiang Lin
    4. Cui Lunbiao
    5. Li Chunyu
    6. Song Guoxin
    7. Xu Rui
    8. Geng Xiangnan
    9. Luan Changxing
    10. Chen Yan
    11. Zhu Baoli
    12. Zhu Wei

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

    1. Daniel Ellis
    2. Natalie Brunette
    3. Katharine H. D. Crawford
    4. Alexandra C. Walls
    5. Minh N. Pham
    6. Chengbo Chen
    7. Karla-Luise Herpoldt
    8. Brooke Fiala
    9. Michael Murphy
    10. Deleah Pettie
    11. John C. Kraft
    12. Keara D. Malone
    13. Mary Jane Navarro
    14. Cassandra Ogohara
    15. Elizabeth Kepl
    16. Rashmi Ravichandran
    17. Claire Sydeman
    18. Maggie Ahlrichs
    19. Max Johnson
    20. Alyssa Blackstone
    21. Lauren Carter
    22. Tyler N. Starr
    23. Allison J. Greaney
    24. Kelly K. Lee
    25. David Veesler
    26. Jesse D. Bloom
    27. Neil P. King

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Viability of MS2 and Phi6 Bacteriophages on Carpet and Dust

    1. Nicholas Nastasi
    2. Nicole Renninger
    3. Ashleigh Bope
    4. Samuel J. Cochran
    5. Justin Greaves
    6. Sarah R. Haines
    7. Neeraja Balasubrahmaniam
    8. Katelyn Stuart
    9. Jenny Panescu
    10. Kyle Bibby
    11. Natalie M. Hull
    12. Karen C. Dannemiller

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells

    1. Nilima Dinesh Kumar
    2. Bram M. ter Ellen
    3. Ellen M. Bouma
    4. Berit Troost
    5. Denise P. I. van de Pol
    6. Heidi H. van der Ende-Metselaar
    7. Djoke van Gosliga
    8. Leonie Apperloo
    9. Orestes A. Carpaij
    10. Maarten van den Berge
    11. Martijn C. Nawijn
    12. Ymkje Stienstra
    13. Izabela A. Rodenhuis-Zybert
    14. Jolanda M. Smit

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

    1. Sirle Saul
    2. Marwah Karim
    3. Luca Ghita
    4. Pei-Tzu Huang
    5. Winston Chiu
    6. Verónica Durán
    7. Chieh-Wen Lo
    8. Sathish Kumar
    9. Nishank Bhalla
    10. Pieter Leyssen
    11. Farhang Alem
    12. Niloufar A. Boghdeh
    13. Do H.N. Tran
    14. Courtney A. Cohen
    15. Jacquelyn A. Brown
    16. Kathleen E. Huie
    17. Courtney Tindle
    18. Mamdouh Sibai
    19. Chengjin Ye
    20. Ahmed Magdy Khalil
    21. Kevin Chiem
    22. Luis Martinez-Sobrido
    23. John M. Dye
    24. Benjamin A. Pinsky
    25. Pradipta Ghosh
    26. Soumita Das
    27. David E. Solow-Cordero
    28. Jing Jin
    29. John P. Wikswo
    30. Dirk Jochmans
    31. Johan Neyts
    32. Steven De Jonghe
    33. Aarthi Narayanan
    34. Shirit Einav

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

    1. Michael I Barton
    2. Stuart A MacGowan
    3. Mikhail A Kutuzov
    4. Omer Dushek
    5. Geoffrey John Barton
    6. P Anton van der Merwe

    • Curated by eLife

      Evaluation Summary:

      This manuscript is of interest to virologists working on SARS-CoV-2, as well as biochemists and biophysicists who perform binding experiments with surface plasmon resonance (SPR), as it provides detailed affinity and kinetics analysis of the effect of mutations in variants of concern in the SARS-CoV-2 receptor binding domain with receptor ACE2 and two 'common' mutations in ACE2.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    6 evaluationsAppears in 2 listsLatest version Latest activity

  7. Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome

    1. Kirstin Mösbauer
    2. Verena Nadin Fritsch
    3. Lorenz Adrian
    4. Jörg Bernhardt
    5. Martin Clemens Horst Gruhlke
    6. Alan John Slusarenko
    7. Daniela Niemeyer
    8. Haike Antelmann

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. A covariation analysis reveals elements of selectivity in quorum sensing systems

    1. Samantha Wellington Miranda
    2. Qian Cong
    3. Amy L Schaefer
    4. Emily Kenna MacLeod
    5. Angelina Zimenko
    6. David Baker
    7. E Peter Greenberg

    • Curated by eLife

      Evaluation Summary:

      Acyl-homoserine lactone (AHL) based quorum sensing systems are an important form of intercellular communication in bacteria. These systems, minimally comprised of a synthase and a receptor, often involve different types of AHLs. This paper demonstrates that amino acids in the active site of the synthase and the binding site of the receptor have co-evolved to provide specificity for different signaling molecules, even though the synthase and receptor do not directly interact. This type of information could potentially be used to rationally engineer synthases and receptors with different specificities, as well as predict the specificities of uncharacterized synthases and receptors.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. A novel mechanosensitive channel controls osmoregulation, differentiation and infectivity in Trypanosoma cruzi

    1. N Dave
    2. U Cetiner
    3. D Arroyo
    4. J Fonbuena
    5. M Tiwari
    6. P Barrera
    7. N Lander
    8. A Anishkin
    9. S Sukharev
    10. V Jimenez

    • Curated by eLife

      Evaluation Summary:

      The authors found a mechanosensitive channel gene in T. cruzi, and aimed to characterize its functions. The authors provide conclusive evidence that TcMscS is a mechanosensitive channel. They also show that TcMscS has additional roles outside of mechanosensation, likely playing a role in the infectivity of T. cruzi.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

    1. Alexandra Schäfer
    2. Lisa E. Gralinski
    3. Sarah R. Leist
    4. Emma S. Winkler
    5. Brea K. Hampton
    6. Michael A. Mooney
    7. Kara L. Jensen
    8. Rachel L. Graham
    9. Sudhakar Agnihothram
    10. Sophia Jeng
    11. Steven Chamberlin
    12. Timothy A. Bell
    13. D. Trevor Scobey
    14. Laura A. VanBlargan
    15. Larissa B. Thackray
    16. Pablo Hock
    17. Darla R. Miller
    18. Ginger D. Shaw
    19. Fernando Pardo Manuel de Villena
    20. Shannon K. McWeeney
    21. Stephanie A. Montgomery
    22. Michael S. Diamond
    23. Mark T. Heise
    24. Vineet D. Menachery
    25. Martin T. Ferris
    26. Ralph S. Baric

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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