Microbiology

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

1. Shelly J. Robertson
2. Olivia Bedard
3. Kristin L. McNally
4. Carl Shaia
5. Chad S. Clancy
6. Matthew Lewis
7. Rebecca M. Broeckel
8. Abhilash I. Chiramel
9. Jeffrey G. Shannon
10. Gail L. Sturdevant
11. Rebecca Rosenke
12. Sarah L. Anzick
13. Elvira Forte
14. Christoph Preuss
15. Candice N. Baker
16. Jeffrey M. Harder
17. Catherine Brunton
18. Steven Munger
19. Daniel P. Bruno
20. Justin B. Lack
21. Jacqueline M. Leung
22. Amirhossein Shamsaddini
23. Paul Gardina
24. Daniel E. Sturdevant
25. Jian Sun
26. Craig Martens
27. Steven M. Holland
28. Nadia A. Rosenthal
29. Sonja M. Best

Reviewed by ScreenIT

A novel hamster model of SARS-CoV-2 respiratory infection using a pseudotyped virus

1. Hiroshi Yamada
2. So-Ichiro Sasaki
3. Hideki Tani
4. Mayu Somekawa
5. Hitoshi Kawasuji
6. Yumiko Saga
7. Yoshihiro Yoshida
8. Yoshihiro Yamamoto
9. Yoshihiro Hayakawa
10. Yoshitomo Morinaga

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Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

1. Thomas Hackl
2. Sarah Duponchel
3. Karina Barenhoff
4. Alexa Weinmann
5. Matthias G Fischer

• Curated by eLife

  Evaluation Summary:

  Approaching the search of novel viruses while in an endogenized stage, rather than as free virions, the study by Hackl et al. reveals a large diversity of complete and fragmented virophage genomes - termed EMALEs- scattered throughout the genomes of four strains of the marine protist Cafeteria. Given that the activation of the integrated virophage mavirus during infection by the giant virus, CroV, has been shown to have a protective effect on the Cafeteria population, this study provides a tantalizing window into the traces of virophage-giant virus¬-protist interactions in the marine environment. Given the enormous diversity of virophages and giant viruses that have been found in metagenomes with no known hosts, this study is a step towards deciphering the biology of these viruses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity

1. Jose L. Garrido
2. Matias Medina
3. Felipe Bravo
4. Sarah McGee
5. Francisco Fuentes
6. Mario Calvo
7. James W. Bowman
8. Christopher D. Bahl
9. Maria Inés Barría
10. Rebecca A. Brachman
11. Raymond A. Alvarez

Reviewed by ScreenIT

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice

1. Alexandra Schäfer
2. David R. Martinez
3. John J. Won
4. Fernando R. Moreira
5. Ariane J. Brown
6. Kendra L. Gully
7. Rao Kalla
8. Kwon Chun
9. Venice Du Pont
10. Darius Babusis
11. Jennifer Tang
12. Eisuke Murakami
13. Raju Subramanian
14. Kimberly T Barrett
15. Blake J. Bleier
16. Roy Bannister
17. Joy Y. Feng
18. John P. Bilello
19. Tomas Cihlar
20. Richard L. Mackman
21. Stephanie A. Montgomery
22. Ralph S. Baric
23. Timothy P. Sheahan

Reviewed by ScreenIT

BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants

1. Jianying Liu
2. Yang Liu
3. Hongjie Xia
4. Jing Zou
5. Scott C. Weaver
6. Kena A. Swanson
7. Hui Cai
8. Mark Cutler
9. David Cooper
10. Alexander Muik
11. Kathrin U. Jansen
12. Ugur Sahin
13. Xuping Xie
14. Philip R. Dormitzer
15. Pei-Yong Shi

Reviewed by ScreenIT

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

1. Jingyou Yu
2. Natalie D. Collins
3. Noe B. Mercado
4. Katherine McMahan
5. Abishek Chandrashekar
6. Jinyan Liu
7. Tochi Anioke
8. Aiquan Chang
9. Victoria M. Giffin
10. David L. Hope
11. Daniel Sellers
12. Felix Nampanya
13. Sarah Gardner
14. Julia Barrett
15. Huahua Wan
16. Jason Velasco
17. Elyse Teow
18. Anthony Cook
19. Alex Van Ry
20. Laurent Pessaint
21. Hanne Andersen
22. Mark G. Lewis
23. Christian Hofer
24. Donald S. Burke
25. Erica K. Barkei
26. Hannah A. D. King
27. Caroline Subra
28. Diane Bolton
29. Kayvon Modjarrad
30. Nelson L. Michael
31. Dan H. Barouch

Reviewed by ScreenIT

Pharmacological perturbation of intracellular dynamics as a SARS-CoV-2 antiviral strategy

1. William Bakhache
2. Emma Partiot
3. Vincent Lucansky
4. Yonis Bare
5. Boris Bonaventure
6. Caroline Goujon
7. Cédric Bories
8. Maika S. Deffieu
9. Raphael Gaudin

Reviewed by ScreenIT

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

1. Christopher Chevillard
2. Axelle Amen
3. Solène Besson
4. Dalil Hannani
5. Isabelle Bally
6. Valentin Dettling
7. Evelyne Gout
8. Christophe J. Moreau
9. Marlyse Buisson
10. Salomé Gallet
11. Daphna Fenel
12. Emilie Vassal-Stermann
13. Guy Schoehn
14. Pascal Poignard
15. Marie-Claire Dagher
16. Pascal Fender

Reviewed by ScreenIT

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

1. Vishwa Patel
2. Nishad Matange

• Curated by eLife

  Evaluation Summary:

  This paper investigates the evolutionary path of Escherichia coli resistance to the antibiotic trimethoprim. The authors show that adaptive mutations that accumulate early are often not in the drug target itself, but rather mutations that lead to transcriptional up-regulation of the drug target. Higher-level resistance can then evolve due to the addition of mutations in the drug target; however, at lower drug concentrations, cells are more likely to accumulate mutations that reverse the fitness defect associated with the initially acquired mutations. Overall, this study shows that regulatory mutations can play a major role in the evolution of antibiotic resistance in bacterial populations, and that the evolutionary path is influenced by the level of drug exposure.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewers #1 , #2, and #3 agreed to share their names with the authors.)

Reviewed by eLife