Infectious Diseases (except HIV/AIDS)

Toxoplasma Infection and Its Sequential Impact on Physical Health, Stress, and Anxiety: A Large Cross-Sectional Study Testing the Stress-Coping Hypothesis

1. Jaroslav Flegr
2. Ashkan Latifi
3. Šárka Kaňková

Reviewed by PREreview

Association of COVID-19 risk factors with systemic fungal infections in hospitalized patients

1. Abbygail C Wilbourn
2. Oleg V Tsodikov
3. Sylvie Garneau-Tsodikova

Reviewed by PREreview

The landscape of paediatric infectious disease exposure in a rural sub-Saharan Africa setting in Kilifi, Kenya: longitudinal serological analysis over two decades and priorities for future vaccine development

1. Deirdre F Foley
2. Timothy K Chege
3. Joyce Kabagenyi
4. Karen McCarthy
5. Elijah T Gicheru
6. Nelson Kibinge
7. Angela W Maina
8. Jacqueline M Waeni
9. Ralf Clemens
10. Sue-Ann Costa Clemens
11. James Tuju
12. Charles J Sande

Reviewed by PREreview

The effect of combining antibiotics on resistance: A systematic review and meta-analysis

1. Berit Siedentop
2. Viacheslav N Kachalov
3. Christopher Witzany
4. Matthias Egger
5. Roger D Kouyos
6. Sebastian Bonhoeffer

• Curated by eLife

  eLife assessment

  This is a methodologically state-of-the-art systematic review and meta-analysis of studies that addressed the question of whether the administration of multiple antibiotics simultaneously prevents antibiotic resistance development in individuals. The findings are solid. Rather than providing a precise answer, the synthesis of studies eligible for analysis leads to the conclusion that "our analysis could not identify any benefit or harm of using a higher or a lower number of antibiotics regarding within-patient resistance development." This article is important as it articulates the existing knowledge gap, but also serves as an example for careful future use of the meta-analysis methodology, when existing data just don't allow conclusions.

Reviewed by eLife

Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

1. Patrick KA Kearns
2. Charles Dixon
3. Mihaly Badonyi
4. Kim Lee
5. Rafal Czapiewski
6. Olivia Fleming
7. Prajitha Nadukkandy
8. Lukas Gerasimivicius
9. Rinal Sahputra
10. Bethany Potts
11. Sam Benton
12. Jacky Guy
13. Scott Neilson
14. Helen Wise
15. Sara Jenks
16. Kate Templeton
17. CIRCO
18. Christina Dold
19. Teresa Lambe
20. Andrew Pollard
21. Alexander J Mentzer
22. Julian C Knight
23. COMBAT
24. Susanna Dunachie
25. Paul Klenerman
26. Eleanor Barnes
27. Alan Carson
28. Laura McWhirter
29. Tracy Hussell
30. Rennos Fragkoudis
31. Susan Rosser
32. David Cavanagh
33. Graeme Cowan
34. Madhvi Menon
35. Joseph A Marsh
36. Dirk A Kleinjan
37. Nick Gilbert

• Curated by eLife

  eLife assessment

  This study provides novel insights into COVID-19 immune responses by using the delta of the normalised accessible surface area (DASA) to map IgM responses to the SARS-CoV-2 Membrane protein M1-subtype across multiple European cohorts. The evidence supporting the findings is solid, with thorough validation and comprehensive analysis, although additional clarity on T-independent B cell reactions and the impact of comorbidities would further strengthen the conclusions. The methods and data presented are valuable for advancing diagnostic and prognostic tools for COVID-19, particularly in the context of long COVID.

Reviewed by eLife

False-positive detection of Group B Streptococcus (GBS) in chromogenic media (Strep B Carrot Broth) due to presence of Enterococcus faecalis in High Vaginal swabs

1. Abhishek Singh
2. Atahar Husein
3. Salomi Singh
4. Vikas Ghattargi
5. Dhiraj Dhotre
6. Yogesh S. Shouche
7. Stacy Colaco
8. Vivek Abhyankar
9. Suyash Patekar
10. Karisma Chhabria
11. Sushil Kumar
12. A. D. Urhekar
13. Deepak Modi

Reviewed by PREreview

Early oral switch in low-risk Staphylococcus aureus bloodstream infection

1. Achim J. Kaasch
2. Luis Eduard López-Cortés
3. Jesús Rodríguez-Baño
4. José Miguel Cisneros
5. M. Dolores Navarro
6. Gerd Fätkenheuer
7. Norma Jung
8. Siegbert Rieg
9. Raphaël Lepeule
10. Laetitia Coutte
11. Louis Bernard
12. Adrien Lemaignen
13. Katrin Kösters
14. Colin R. MacKenzie
15. Alex Soriano
16. Stefan Hagel
17. Bruno Fantin
18. Matthieu Lafaurie
19. Jean-Philippe Talarmin
20. Aurélien Dinh
21. Thomas Guimard
22. David Boutoille
23. Tobias Welte
24. Stefan Reuter
25. Jan Kluytmans
26. Maria Luisa Martin
27. Emmanuel Forestier
28. Hartmut Stocker
29. Virginie Vitrat
30. Pierre Tattevin
31. Anna Rommerskirchen
32. Marion Noret
33. Anne Adams
34. Winfried V. Kern
35. Martin Hellmich
36. Harald Seifert
37. SABATO study group (members and affiliations listed in Acknowledgement record)

Reviewed by Rapid Reviews Infectious Diseases

Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam

1. Nguyen Lam Vuong
2. Nguyen Than Ha Quyen
3. Nguyen Thi Hanh Tien
4. Kien Duong Thi Hue
5. Huynh Thi Le Duyen
6. Phung Khanh Lam
7. Dong Thi Hoai Tam
8. Tran Van Ngoc
9. Thomas Jaenisch
10. Cameron P Simmons
11. Sophie Yacoub
12. Bridget A Wills
13. Ronald Geskus

• Curated by eLife

  eLife assessment

  This manuscript by Vuong and colleagues reports on the kinetics of viremia in a large set of individuals from Vietnam. In the large cohort, all 4 dengue serotypes are represented and the authors try to correlate viraemia measured at various days from illness onset with thrombocytopaenia and severe dengue, according to the WHO 2009 classification scheme. These are fundamental findings that provide compelling evidence of the importance of measuring viremia early in the phase of the disease. These data will help to inform the design of studies of antiviral drugs against dengue.

Reviewed by eLife

Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

1. Joanna C Porter
2. Jamie Inshaw
3. Vincente Joel Solis
4. Emma Denneny
5. Rebecca Evans
6. Mia I Temkin
7. Nathalia De Vasconcelos
8. Iker Valle Aramburu
9. Dennis Hoving
10. Donna Basire
11. Tracey Crissell
12. Jesusa Guinto
13. Alison Webb
14. Hanif Esmail
15. Victoria Johnston
16. Anna Last
17. Thomas Rampling
18. Lena Lippert
19. Elisa Theresa Helbig
20. Florian Kurth
21. Bryan Williams
22. Aiden Flynn
23. Pauline T Lukey
24. Veronique Birault
25. Venizelos Papayannopoulos

• Curated by eLife

  eLife assessment

  This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

1. Sean V Connelly
2. Nicholas F Brazeau
3. Mwinyi Msellem
4. Billy E Ngasala
5. Ozkan Aydemir
6. Varun Goel
7. Karamoko Niaré
8. David J Giesbrecht
9. Zachary R Popkin-Hall
10. Chris Hennelly
11. Zackary Park
12. Ann M Moormann
13. John M Ong'echa
14. Robert Verity
15. Safia Mohammed
16. Shija J Shija
17. Lwidiko E Mhamilawa
18. Ulrika Morris
19. Andreas Mårtensson
20. Jessica T Lin
21. Anders Björkman
22. Jonathan J Juliano
23. Jeffrey A Bailey

• Curated by eLife

  eLife assessment

  Connelly and colleagues provide convincing genetic evidence that importation from mainland Tanzania is a major source of Plasmodium falciparum lineages currently circulating in Zanzibar. This study also reveals ongoing local malaria transmission and occasional near-clonal outbreaks in Zanzibar. Overall, the manuscript effectively highlights the role of human movements in maintaining residual malaria transmission in an area targeted for intensive control interventions over the past decades and provides clear and valuable information for epidemiologists and public health professionals.

Reviewed by eLife