Immunology

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

1. Ashley Zani
2. Adam D. Kenney
3. Jeffrey Kawahara
4. Adrian C. Eddy
5. Xiao-Liang Wang
6. Mahesh KC
7. Mijia Lu
8. Emily A. Hemann
9. Jianrong Li
10. Mark E. Peeples
11. Luanne Hall-Stoodley
12. Adriana Forero
13. Chuanxi Cai
14. Jianjie Ma
15. Jacob S. Yount

Reviewed by ScreenIT

Structural basis for antibody resistance to SARS-CoV-2 omicron variant

1. Gabriele Cerutti
2. Yicheng Guo
3. Lihong Liu
4. Zhening Zhang
5. Liyuan Liu
6. Yang Luo
7. Yiming Huang
8. Harris H. Wang
9. David D. Ho
10. Zizhang Sheng
11. Lawrence Shapiro

Reviewed by ScreenIT

Anti-SARS-CoV-2 human antibodies retaining neutralizing activity against SARS-CoV-2 B.1.1.529 (omicron)

1. Maya Imbrechts
2. Winnie Kerstens
3. Madina Rasulova
4. Thomas Vercruysse
5. Wim Maes
6. Louanne Ampofo
7. Karen Ven
8. Jeroen Lammertyn
9. Karen Vanhoorelbeke
10. Nico Callewaert
11. Johan Neyts
12. Kai Dallmeier
13. Paul Declerck
14. Hendrik Jan Thibaut
15. Nick Geukens

Reviewed by ScreenIT

Virus-Like Particles Are Efficient Tools for Boosting mRNA-Induced Antibodies

1. Anne-Cathrine S. Vogt
2. Lukas Jörg
3. Byron Martina
4. Pascal S. Krenger
5. Xinyue Chang
6. Andris Zeltins
7. Monique Vogel
8. Mona O. Mohsen
9. Martin F. Bachmann

Reviewed by ScreenIT

Longitudinal characterisation of phagocytic and neutralisation functions of anti-Spike antibodies in plasma of patients after SARS-CoV-2 infection

1. Anurag Adhikari
2. Arunasingam Abayasingam
3. Chaturaka Rodrigo
4. David Agapiou
5. Elvis Pandzic
6. Nicholas A Brasher
7. Bentotage Samitha Madushan Fernando
8. Elizabeth Keoshkerian
9. Hui Li
10. Ha Na Kim
11. Megan Lord
12. Gordona Popovic
13. William Rawlinson
14. Michael Mina
15. Jeffrey J Post
16. Bernard Hudson
17. Nicole Gilroy
18. Adam W. Bartlett
19. Golo Ahlenstiel
20. Branka Grubor-Bauk
21. Dominic Dwyer
22. Pamela Konecny
23. Andrew R Lloyd
24. Marianne Martinello
25. Rowena A Bull
26. Nicodemus Tedla

Reviewed by ScreenIT

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

1. Venkata-Viswanadh Edara
2. Kelly E. Manning
3. Madison Ellis
4. Lilin Lai
5. Kathryn M. Moore
6. Stephanie L. Foster
7. Katharine Floyd
8. Meredith E. Davis-Gardner
9. Grace Mantus
10. Lindsay E. Nyhoff
11. Sarah Bechnak
12. Ghina Alaaeddine
13. Amal Naji
14. Hady Samaha
15. Matthew Lee
16. Laurel Bristow
17. Matthew Gagne
18. Jesmine Roberts-Torres
19. Amy R. Henry
20. Sucheta Godbole
21. Arash Grakoui
22. Marybeth Saxton
23. Anne Piantadosi
24. Jesse J. Waggoner
25. Daniel C. Douek
26. Nadine Rouphael
27. Jens Wrammert
28. Mehul S. Suthar

Reviewed by ScreenIT

Blockade of TMPRSS2-mediated priming of SARS-CoV-2 by lactoferricin

1. Anna Ohradanova-Repic
2. Rostislav Skrabana
3. Laura Gebetsberger
4. Gabor Tajti
5. Peter Baráth
6. Gabriela Ondrovičová
7. Romana Praženicová
8. Nikola Jantova
9. Patricia Hrasnova
10. Hannes Stockinger
11. Vladimir Leksa

Reviewed by ScreenIT

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells

1. Aurélien Sokal
2. Matteo Broketa
3. Annalisa Meola
4. Giovanna Barba-Spaeth
5. Ignacio Fernández
6. Slim Fourati
7. Imane Azzaoui
8. Andrea de La Selle
9. Alexis Vandenberghe
10. Anais Roeser
11. Magali Bouvier-Alias
12. Etienne Crickx
13. Laetitia Languille
14. Marc Michel
15. Bertrand Godeau
16. Sébastien Gallien
17. Giovanna Melica
18. Yann Nguyen
19. Virginie Zarrouk
20. Florence Canoui-Poitrine
21. France Noizat-Pirenne
22. Jérôme Megret
23. Jean-Michel Pawlotsky
24. Simon Fillatreau
25. Etienne Simon-Lorière
26. Jean-Claude Weill
27. Claude-Agnès Reynaud
28. Félix A. Rey
29. Pierre Bruhns
30. Pascal Chappert
31. Matthieu Mahévas

Reviewed by ScreenIT

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

1. Noella Lopes
2. Nicolas Boucherit
3. Jérémy C Santamaria
4. Nathan Provin
5. Jonathan Charaix
6. Pierre Ferrier
7. Matthieu Giraud
8. Magali Irla

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of immunology and especially in the induction of immune tolerance in the thymus. The work uses several mouse models to substantially broaden the current understanding of MHCII/TCR -mediated cell-cell crosstalk in the thymus and suggests a novel mechanism that contributes to the generation of functional and self-tolerant T-cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

1. Magdalena L Russell
2. Aisha Souquette
3. David M Levine
4. Stefan A Schattgen
5. E Kaitlynn Allen
6. Guillermina Kuan
7. Noah Simon
8. Angel Balmaseda
9. Aubree Gordon
10. Paul G Thomas
11. Frederick A Matsen
12. Philip Bradley

• Curated by eLife

  Evaluation Summary:

  This study demonstrates that differences in areas outside the regions that encode the TCR genes can affect the properties of TCRs that get made. This paper will be of interest to a broad swathe of immunologists who study such variable lymphocyte receptors. It combines several large datasets in an extremely statistically rigorous analysis, producing results consistent with but substantially expanding upon the prior knowledge of the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife