1. A SARS CoV-2 nucleocapsid vaccine protects against distal viral dissemination

    This article has 4 authors:
    1. Jacob Class
    2. Tanushree Dangi
    3. Justin M. Richner
    4. Pablo Penaloza-MacMaster

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  2. The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

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    1. Thushan I. de Silva
    2. Guihai Liu
    3. Benjamin B. Lindsey
    4. Danning Dong
    5. Shona C. Moore
    6. Nienyun Sharon Hsu
    7. Dhruv Shah
    8. Dannielle Wellington
    9. Alexander J. Mentzer
    10. Adrienn Angyal
    11. Rebecca Brown
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    799. Agnieska Szemiel
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    801. Jolanta Tanianis-Hughes
    802. Jordan Thomas
    803. Erwan Trochu
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    806. J. Eunice Zhang
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    863. Andrew Drummond
    864. Ingrid DuRand
    865. Ahilanadan Dushianthan
    866. Tristan Dyer
    867. Cariad Evans
    868. Chi Eziefula
    869. Chrisopher Fegan
    870. Adam Finn
    871. Duncan Fullerton
    872. Sanjeev Garg
    873. Sanjeev Garg
    874. Atul Garg
    875. Effrossyni Gkrania-Klotsas
    876. Jo Godden
    877. Arthur Goldsmith
    878. Clive Graham
    879. Elaine Hardy
    880. Stuart Hartshorn
    881. Daniel Harvey
    882. Peter Havalda
    883. Daniel B. Hawcutt
    884. Maria Hobrok
    885. Luke Hodgson
    886. Anil Hormis
    887. Michael Jacobs
    888. Susan Jain
    889. Paul Jennings
    890. Agilan Kaliappan
    891. Vidya Kasipandian
    892. Stephen Kegg
    893. Michael Kelsey
    894. Jason Kendall
    895. Caroline Kerrison
    896. Ian Kerslake
    897. Oliver Koch
    898. Gouri Koduri
    899. George Koshy
    900. Shondipon Laha
    901. Steven Laird
    902. Susan Larkin
    903. Tamas Leiner
    904. Patrick Lillie
    905. James Limb
    906. Vanessa Linnett
    907. Jeff Little
    908. Mark Lyttle
    909. Michael MacMahon
    910. Emily MacNaughton
    911. Ravish Mankregod
    912. Huw Masson
    913. Elijah Matovu
    914. Katherine McCullough
    915. Ruth McEwen
    916. Manjula Meda
    917. Gary Mills
    918. Jane Minton
    919. Mariyam Mirfenderesky
    920. Kavya Mohandas
    921. Quen Mok
    922. James Moon
    923. Elinoor Moore
    924. Patrick Morgan
    925. Craig Morris
    926. Katherine Mortimore
    927. Samuel Moses
    928. Mbiye Mpenge
    929. Rohinton Mulla
    930. Michael Murphy
    931. Megan Nagel
    932. Thapas Nagarajan
    933. Mark Nelson
    934. Lillian Norris
    935. Matthew K. O'Shea
    936. Igor Otahal
    937. Marlies Ostermann
    938. Mark Pais
    939. Carlo Palmieri
    940. Selva Panchatsharam
    941. Danai Papakonstantinou
    942. Hassan Paraiso
    943. Brij Patel
    944. Natalie Pattison
    945. Justin Pepperell
    946. Mark Peters
    947. Mandeep Phull
    948. Stefania Pintus
    949. Jagtur Singh Pooni
    950. Tim Planche
    951. Frank Post
    952. David Price
    953. Rachel Prout
    954. Nikolas Rae
    955. Henrik Reschreiter
    956. Tim Reynolds
    957. Neil Richardson
    958. Mark Roberts
    959. Devender Roberts
    960. Alistair Rose
    961. Guy Rousseau
    962. Bobby Ruge
    963. Brendan Ryan
    964. Taranprit Saluja
    965. Matthias L. Schmid
    966. Aarti Shah
    967. Prad Shanmuga
    968. Anil Sharma
    969. Anna Shawcross
    970. Jeremy Sizer
    971. Manu Shankar-Hari
    972. Richard Smith
    973. Catherine Snelson
    974. Nick Spittle
    975. Nikki Staines
    976. Tom Stambach
    977. Richard Stewart
    978. Pradeep Subudhi
    979. Tamas Szakmany
    980. Kate Tatham
    981. Jo Thomas
    982. Chris Thompson
    983. Robert Thompson
    984. Ascanio Tridente
    985. Darell Tupper-Carey
    986. Mary Twagira
    987. Nick Vallotton
    988. Rama Vancheeswaran
    989. Lisa Vincent-Smith
    990. Shico Visuvanathan
    991. Alan Vuylsteke
    992. Sam Waddy
    993. Rachel Wake
    994. Andrew Walden
    995. Ingeborg Welters
    996. Tony Whitehouse
    997. Paul Whittaker
    998. Ashley Whittington
    999. Padmasayee Papineni
    1000. Meme Wijesinghe
    1001. Martin Williams
    1002. Lawrence Wilson
    1003. Sarah Cole
    1004. Stephen Winchester
    1005. Martin Wiselka
    1006. Adam Wolverson
    1007. Daniel G. Wootton
    1008. Andrew Workman
    1009. Bryan Yates
    1010. Peter Young
    1011. Yanchun Peng
    1012. Sarah L. Rowland-Jones
    1013. Tao Dong

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  3. Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

    This article has 57 authors:
    1. Hannah A. D. King
    2. M. Gordon Joyce
    3. Ines Lakhal-Naouar
    4. Aslaa Ahmed
    5. Camila Macedo Cincotta
    6. Caroline Subra
    7. Kristina K. Peachman
    8. Holly R. Hack
    9. Rita E. Chen
    10. Paul V. Thomas
    11. Wei-Hung Chen
    12. Rajeshwer S. Sankhala
    13. Agnes Hajduczki
    14. Elizabeth J. Martinez
    15. Caroline E. Peterson
    16. William C. Chang
    17. Misook Choe
    18. Clayton Smith
    19. Jarrett A. Headley
    20. Hanne A. Elyard
    21. Anthony Cook
    22. Alexander Anderson
    23. Kathryn McGuckin Wuertz
    24. Ming Dong
    25. Isabella Swafford
    26. James B. Case
    27. Jeffrey R. Currier
    28. Kerri G. Lal
    29. Mihret F. Amare
    30. Vincent Dussupt
    31. Sebastian Molnar
    32. Sharon P. Daye
    33. Xiankun Zeng
    34. Erica K. Barkei
    35. Kendra Alfson
    36. Hilary M. Staples
    37. Ricardo Carrion
    38. Shelly J. Krebs
    39. Dominic Paquin-Proulx
    40. Nicos Karasavvas
    41. Victoria R. Polonis
    42. Linda L. Jagodzinski
    43. Sandhya Vasan
    44. Paul T. Scott
    45. Yaoxing Huang
    46. Manoj S. Nair
    47. David D. Ho
    48. Natalia de Val
    49. Michael S. Diamond
    50. Mark G. Lewis
    51. Mangala Rao
    52. Gary R. Matyas
    53. Gregory D. Gromowski
    54. Sheila A. Peel
    55. Nelson L. Michael
    56. Kayvon Modjarrad
    57. Diane L. Bolton

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  4. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

    This article has 18 authors:
    1. Leo Hanke
    2. Hrishikesh Das
    3. Daniel J. Sheward
    4. Laura Perez Vidakovics
    5. Egon Urgard
    6. Ainhoa Moliner-Morro
    7. Changil Kim
    8. Vivien Karl
    9. Alec Pankow
    10. Natalie L. Smith
    11. Bartlomiej Porebski
    12. Oscar Fernandez-Capetillo
    13. Erdinc Sezgin
    14. Gabriel K. Pedersen
    15. Jonathan M. Coquet
    16. B. Martin Hällberg
    17. Ben Murrell
    18. Gerald M. McInerney

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  5. Longitudinal characterization of humoral and cellular immunity in hospitalized COVID-19 patients reveal immune persistence up to 9 months after infection

    This article has 25 authors:
    1. John Tyler Sandberg
    2. Renata Varnaitė
    3. Wanda Christ
    4. Puran Chen
    5. Jagadeeswara R. Muvva
    6. Kimia T. Maleki
    7. Marina García
    8. Majda Dzidic
    9. Elin Folkesson
    10. Magdalena Skagerberg
    11. Gustaf Ahlén
    12. Lars Frelin
    13. Matti Sällberg
    14. The Karolinska COVID-19 Study Group
    15. Lars I. Eriksson
    16. Olav Rooyackers
    17. Anders Sönnerborg
    18. Marcus Buggert
    19. Niklas K. Björkström
    20. Soo Aleman
    21. Kristoffer Strålin
    22. Jonas Klingström
    23. Hans-Gustaf Ljunggren
    24. Kim Blom
    25. Sara Gredmark-Russ

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  6. Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19

    This article has 59 authors:
    1. Lorenz Thurner
    2. Natalie Fadle
    3. Moritz Bewarder
    4. Igor Kos
    5. Evi Regitz
    6. Bernhard Thurner
    7. Yvan Fischer
    8. Onur Cetin
    9. Torben Rixecker
    10. Marie-Christin Hoffmann
    11. Klaus-Dieter Preuss
    12. Claudia Schormann
    13. Frank Neumann
    14. Sylvia Hartmann
    15. Theresa Bock
    16. Dominic Kaddu-Mulindwa
    17. Birgit Bette
    18. Klaus Roemer
    19. Joerg Thomas Bittenbring
    20. Konstantinos Christofyllakis
    21. Angelika Bick
    22. Vadim Lesan
    23. Zanir Abdi
    24. Sebastian Mang
    25. André Becker
    26. Carlos Metz
    27. Frederik Seiler
    28. Johannes Lehmann
    29. Philipp Agne
    30. Thomas Adams
    31. Andreas Link
    32. Christian Werner
    33. Angela Thiel-Bodenstaff
    34. Matthias Reichert
    35. Guy Danziger
    36. Sophie Roth
    37. Cihan Papan
    38. Jan Pilch
    39. Thorsten Pfuhl
    40. Patrick Wuchter
    41. Christian Herr
    42. Stefan Lohse
    43. Hubert Schrezenmeier
    44. Michael Boehm
    45. Frank Langer
    46. Gereon Gäbelein
    47. Bettina Friesenhahn-Ochs
    48. Christoph Kessel
    49. Dirk Foell
    50. Robert Bals
    51. Frank Lammert
    52. Sixten Körper
    53. Jürgen Rissland
    54. Christian Lensch
    55. Stephan Stilgenbauer
    56. Sören L. Becker
    57. Sigrun Smola
    58. Marcin Krawczyk
    59. Philipp M. Lepper

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  7. Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

    This article has 7 authors:
    1. Adam Pickard
    2. Ben C. Calverley
    3. Joan Chang
    4. Richa Garva
    5. Sara Gago
    6. Yinhui Lu
    7. Karl E. Kadler

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  8. HIF1α is required for NK cell metabolic adaptation during virus infection

    This article has 11 authors:
    1. Francisco Victorino
    2. Tarin M Bigley
    3. Eugene Park
    4. Cong-Hui Yao
    5. Jeanne Benoit
    6. Li-Ping Yang
    7. Sytse J Piersma
    8. Elvin J Lauron
    9. Rebecca M Davidson
    10. Gary J Patti
    11. Wayne M Yokoyama
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      By using mice lacking the hypoxia inducible factor-1α (HIF1α) in NK cells, the study unravels a previously unknown function of this transcription factor in virus control by NK cells. Mechanistically, the authors provided evidence that HIF1α supports survival of NK cells through an efficient glucose metabolism required for optimal NK cell response to viral infection.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

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  9. Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

    This article has 14 authors:
    1. Isabelle J Marié
    2. Lara Brambilla
    3. Doua Azzouz
    4. Ze Chen
    5. Gisele V Baracho
    6. Azlann Arnett
    7. Haiyan S Li
    8. Weiguo Liu
    9. Luisa Cimmino
    10. Pratip Chattopadhyay
    11. Gregg Silverman
    12. Stephanie S Watowich
    13. Bernard Khor
    14. David E Levy
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript describes a critical function for interferons (IFNs) in suppression of spontaneous autoinflammatory disease. The inflammatory disease is seen in mice lacking all types (I, II, III) of IFN signaling and is ameliorated by deficiency in interleukin-17 as well as by antibiotic treatment. The latter result implies a role for the microbiota in disease pathogenesis, but it remains unclear whether or how IFNs regulate the microbiota composition, whether this occurs across genetic backgrounds or housing conditions, or how exactly IFN deficiency leads to inflammatory disease. Nevertheless this work demonstrates a critical regulatory function for tonic IFN signaling in suppressing autoinflammation that serves as a foundation for future studies and will be of interest to a broad audience of immunologists.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

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  10. The discriminatory power of the T cell receptor

    This article has 9 authors:
    1. Johannes Pettmann
    2. Anna Huhn
    3. Enas Abu Shah
    4. Mikhail A Kutuzov
    5. Daniel B Wilson
    6. Michael L Dustin
    7. Simon J Davis
    8. P Anton van der Merwe
    9. Omer Dushek
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper will be of considerable interest to anybody focusing on highly sensitive T cell antigen recognition. It uses an extended experimental protocol and analytical methods to assess very low T cell receptor binding affinities, and to determine how T cells discriminate between self- and non-self antigens. The main conclusions are well supported by the presented analysis and provide a novel view on a previously considered concept.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors)

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