HIV/AIDS

Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

1. Céline Fombellida-Lopez
2. Aurelija Valaitienė
3. Lee Winchester
4. Nathalie Maes
5. Patricia Dellot
6. Céline Vanwinge
7. Aurélie Ladang
8. Etienne Cavalier
9. Fabrice Susin
10. Dolores Vaira
11. Marie-Pierre Hayette
12. Catherine Reenaers
13. Michel Moutschen
14. Courtney V Fletcher
15. Alexander O Pasternak
16. Gilles Darcis

• Curated by eLife

  eLife Assessment

  This valuable study tested whether several months of dolutegravir intensification alters the size of the HIV reservoir as well as immune activation in individuals already on suppressive ART. While the general study approach is appropriate and the paper is well written, the evidence supporting the claims of the authors is incomplete. The title of the paper is only partially supported by the data, based on specific issues with the study design and analysis plan highlighted by Reviewer 1. Specifically, the primary study outcomes were not clearly described a priori, the plausibility of a biologic effect is uncertain based on lack of a consistent effect across participants, and sample size is small. Given a possible observed partial effect and relevant hypothesis, this approach warrants study in a larger trial.

Reviewed by eLife

Excess HIV infections and costs associated with reductions in HIV prevention services in the United States: Projection using real-world data

1. Patrick S Sullivan
2. Kristin M Wall
3. Marta Juhasz
4. Greg Millett
5. Jeffrey Crowley
6. Chris Beyrer
7. Stephanie DuBose
8. Kamaria Brisco
9. Gordon Le
10. Kenneth Mayer

Reviewed by Rapid Reviews Infectious Diseases, PREreview

HIV incidence among non-migrating persons following a household migration event: a population-based, longitudinal study in Uganda

1. R. Young
2. J. Ssekasanvu
3. J. Kagaayi
4. R. Ssekubugu
5. G. Kigozi
6. S.J. Reynolds
7. M.J. Wawer
8. B.A.S. Nonyane
9. Betty Nantume
10. Thomas C. Quinn
11. Aaron A.R. Tobian
12. John Santelli
13. L.W. Chang
14. C.E. Kennedy
15. L. Paina
16. P.A. Anglewicz
17. D. Serwadda
18. F. Nalugoda
19. M.K. Grabowski

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Impact of an international HIV funding crisis on HIV infections and mortality in low-income and middle-income countries: a modelling study

1. Debra ten Brink
2. Rowan Martin-Hughes
3. Anna L Bowring
4. Nisaa Wulan
5. Kelvin Burke
6. Tom Tidhar
7. Shona Dalal
8. Nick Scott

Reviewed by PREreview

Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection

1. Kavidha Reddy
2. Guinevere Q Lee
3. Nicole Reddy
4. Tatenda JB Chikowore
5. Kathy Baisley
6. Krista L Dong
7. Bruce D Walker
8. Xu G Yu
9. Mathias Lichterfeld
10. Thumbi Ndung'u

• Curated by eLife

  eLife Assessment

  This fundamental, clearly written, and timely manuscript links the timing of ART with the kinetics of total and intact proviral HIV DNA. The conclusions are interesting and novel, and the importance of the work is high because the focus is on African women and clade C virus, both of which are understudied in the HIV reservoir field. The strength of the evidence is compelling. Overall, this work will be of very high interest to scientists and clinicians in the HIV cure/persistence fields.

Reviewed by eLife, Rapid Reviews Infectious Diseases

Prior antiretroviral therapy exposure among clients presenting for HIV treatment initiation in South Africa: an exploratory mixed-methods study using multiple indicators of exposure

1. Mariet Benade
2. Mhairi Maskew
3. Vinolia Ntjikelane
4. Nancy Scott
5. Nkosinathi Ngcobo
6. Brooke Nichols
7. Lufuno Malala
8. Musa Manganye
9. Sydney Rosen

Reviewed by PREreview

Gene dysregulation among virally suppressed people living with HIV links to non-AIDS defining cancer pathways

1. Bryan C. Quach
2. Eric Earley
3. Linran Zhou
4. Caryn Willis
5. Jesse A. Marks
6. Jeran K. Stratford
7. Fang Fang
8. Laura J. Bierut
9. M-J S. Milloy
10. Kanna Hayashi
11. Kora DeBeck
12. Dana B. Hancock
13. Ke Xu
14. Bradley E. Aouizerat
15. Eric O. Johnson

Reviewed by Rapid Reviews Infectious Diseases

Do community-level factors play a role in HIV self-testing uptake, linkage to services and HIV-related outcomes? A mixed methods study of community-led HIV self-testing in rural Zimbabwe

1. Mary K. Tumushime
2. Nancy Ruhode
3. Melissa Neuman
4. Constancia Watadzaushe
5. Miriam Mutseta
6. Miriam Taegtmeyer
7. Cheryl C. Johnson
8. Karin Hatzold
9. Elizabeth L. Corbett
10. Frances M. Cowan
11. Euphemia L. Sibanda

Reviewed by Rapid Reviews Infectious Diseases

Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage

1. Andrea Brizzi
2. Joseph Kagaayi
3. Robert Ssekubugu
4. Lucie Abeler-Dörner
5. Alexandra Blenkinsop
6. David Bonsall
7. Larry W. Chang
8. Christophe Fraser
9. Ronald M. Galiwango
10. Godfrey Kigozi
11. Imogen Kyle
12. Mélodie Monod
13. Gertrude Nakigozi
14. Fred Nalugoda
15. Joseph G. Rosen
16. Oliver Laeyendecker
17. Thomas C. Quinn
18. M. Kate Grabowski
19. Steven J. Reynolds
20. Oliver Ratmann

Reviewed by Rapid Reviews Infectious Diseases

Antiretroviral therapy retention, adherence, and clinical outcomes among postpartum women with HIV in Nigeria

1. Clara M. Young
2. Charlotte A. Chang
3. Atiene S. Sagay
4. Godwin Imade
5. Olabanjo O. Ogunsola
6. Prosper Okonkwo
7. Phyllis J. Kanki

Reviewed by Rapid Reviews Infectious Diseases