Genomics

Betacoronavirus-specific alternate splicing

1. Guy Karlebach
2. Bruce Aronow
3. Stephen B. Baylin
4. Daniel Butler
5. Jonathan Foox
6. Shawn Levy
7. Cem Meydan
8. Christopher Mozsary
9. Amanda M. Saravia-Butler
10. Deanne M. Taylor
11. Eve Wurtele
12. Christopher E. Mason
13. Afshin Beheshti
14. Peter N. Robinson

Reviewed by ScreenIT

CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

1. Chengkun Wang
2. Ravi K. Dinesh
3. Yuanhao Qu
4. Arjun Rustagi
5. Henry Cousins
6. James Zengel
7. Tianyi Zhang
8. Nicholas Magazine
9. Yinglong Guo
10. Taryn Hall
11. Aimee Beck
12. Lucas Miecho Heilbroner
13. Grace Peters-Schulze
14. Aaron Wilk
15. Luke Tso
16. Elif Tokar Erdemic
17. Kae Tanudtanud
18. Sheng Ren
19. Kathy Tzy-Hwa Tzeng
20. Mengdi Wang
21. Brooke Howitt
22. Weishan Huang
23. Jan Carette
24. Russ Altman
25. Catherine A. Blish
26. Le Cong

Reviewed by ScreenIT

Detection of potential new SARS-CoV-2 Gamma-related lineage in Tocantins shows the spread and ongoing evolution of P.1 in Brazil

1. U.J.B. Souza
2. R.N. Santos
3. A. Belmok
4. F.L. Melo
5. J.D. Galvão
6. S.B. Damasceno
7. T.C.V. Rezende
8. M.S. Andrade
9. B.M. Ribeiro
10. J.C. Ribeiro Junior
11. R.F. Carvalho
12. I.G.C. Santos
13. M.S. Oliveira
14. F.R. Spilki
15. F.S. Campos

Reviewed by ScreenIT

Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

1. Corbin SC Johnson
2. Carol A Shively
3. Kristofer T Michalson
4. Amanda J Lea
5. Ryne J DeBo
6. Timothy D Howard
7. Gregory A Hawkins
8. Susan E Appt
9. Yongmei Liu
10. Charles E McCall
11. David M Herrington
12. Edward H Ip
13. Thomas C Register
14. Noah Snyder-Mackler

• Curated by eLife

  Evaluation Summary:

  This is an interesting study aiming to link the evolutionary effects of dietary mismatch in humans to increased inflammatory responses and risk of chronic diseases. To uncover more insights into the causal links, the study used a non-human primate (macaque) model to show that the dietary switch from a Mediterranean to a modern Western diet leads to the polarisation of monocyte cell populations toward a more pro-inflammatory state, which in addition to increasing the chronic health risk can also impose behavioural changes such as anxiety and social isolation. The results of this study are convincing, interesting, and have fundamental importance in evolutionary biology, immunology and psychology. The extent to which these findings can be extrapolated to human populations remains to be established.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Unsupervised classification of SARS-CoV-2 genomic sequences uncovers hidden genetic diversity and suggests an efficient strategy for genomic surveillance

1. Matteo Chiara
2. David S. Horner
3. Erika Ferrandi
4. Carmela Gissi
5. Graziano Pesole

Reviewed by ScreenIT

Mapping the host protein interactome of non-coding regions in SARS-CoV-2 genome

1. Liuyiqi Jiang
2. Mu Xiao
3. Qing-Qing Liao
4. Luqian Zheng
5. Chunyan Li
6. Yuemei Liu
7. Bing Yang
8. Aiming Ren
9. Chao Jiang
10. Xin-Hua Feng

Reviewed by ScreenIT

Genetic diversity and evolution of SARS-CoV-2 in Belgium during the first wave outbreak

1. Tony Wawina-Bokalanga
2. Joan Martí-Carreras
3. Bert Vanmechelen
4. Mandy Bloemen
5. Elke Wollants
6. Lies Laenen
7. Lize Cuypers
8. Kurt Beuselinck
9. Katrien Lagrou
10. Emmanuel André
11. Marc Van Ranst
12. Piet Maes

Reviewed by ScreenIT

Predicting gene regulatory networks from multi-omics to link genetic risk variants and neuroimmunology to Alzheimer’s disease phenotypes

1. Saniya Khullar
2. Daifeng Wang

Reviewed by ScreenIT

Visual and Quantitative Analyses of Virus Genomic Sequences using a Metric-based Algorithm

1. Alexandra Belinsky
2. Guennadi A. Kouzaev

Reviewed by ScreenIT

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020—March 2021) Using a Statistical Learning Strategy

1. Lue Ping Zhao
2. Terry P. Lybrand
3. Peter B. Gilbert
4. Thomas R. Hawn
5. Joshua T. Schiffer
6. Leonidas Stamatatos
7. Thomas H. Payne
8. Lindsay N. Carpp
9. Daniel E. Geraghty
10. Keith R. Jerome

Reviewed by ScreenIT