Genomics

Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration

1. Julian Wolf
2. Anja Schlecht
3. Dennis-Dominik Rosmus
4. Stefaniya Boneva
5. Hansjürgen Agostini
6. Günther Schlunck
7. Peter Wieghofer
8. Clemens Lange

• Curated by eLife

  Evaluation Summary:

  The authors present here an analysis of the gene expression patterns of lesions as found in patients wet age-related macular degeneration, known as choroidal neovascularization. This gene expression analysis is compared to an experimental mouse model. Using this analysis, the authors have identified a candidate target, FN14, as a potential target for the treatment of choroidal neovascularization. Identifying an alternative treatment modality is important for the treatment of these lesions beyond the current standard of care.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Genome assembly of the roundjaw bonefish (Albula glossodonta), a vulnerable circumtropical sportfish

1. Brandon D. Pickett
2. Sheena Talma
3. Jessica R. Glass
4. Daniel Ence
5. Timothy P. Johnson
6. Paul D. Cowley
7. Perry G. Ridge
8. John S. K. Kauwe

Reviewed by GigaByte

COVID-19 infection and transmission includes complex sequence diversity

1. Ernest R. Chan
2. Lucas D. Jones
3. Marlin Linger
4. Jeffrey D. Kovach
5. Maria M. Torres-Teran
6. Audric Wertz
7. Curtis J. Donskey
8. Peter A. Zimmerman

Reviewed by ScreenIT

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses using gene expression profiles of chemical and genetic perturbations

1. Zhewei Shen
2. Anna Halberg
3. Jia Yi Fong
4. Jingyu Guo
5. Gavin Song
6. Brent Louie
7. Gregory R. Luedtke
8. Viwat Visuthikraisee
9. Andy Protter
10. Xiaoying Koh
11. Taegon Baik
12. Pek Yee Lum

Reviewed by ScreenIT

Tracking the circulating SARS-CoV-2 variants in Turkey: Complete genome sequencing and molecular characterization of 1000 SARS-CoV-2 samples

1. Faruk Berat Akçeşme
2. Tuğba Kul Köprülü
3. Burçin Erkal
4. Şeyma İş
5. Birsen Cevher Keskin
6. Betül Akçeşme
7. Kürşad Nuri Baydili
8. Bahar Gezer
9. Jülide Balkan
10. Bihter Uçar
11. Osman Gürsoy
12. Mehmet Taha Yıldız
13. Halil Kurt
14. Nevzat Ünal
15. Mustafa Altındiş
16. Celalettin Korkmaz
17. Hasan Türkez
18. Özlem Bayraktar
19. Barış Demirkol
20. Yasemin Çağ
21. Melih Akay Arslan
22. Hilal Abakay
23. Şükran Köse
24. Abdülkadir Özel
25. Neslihan Mutluay
26. Şaban Tekin

Reviewed by ScreenIT

Genomic surveillance unfolds the dynamics of SARS-CoV-2 transmission and divergence in Bangladesh over the past two years

1. Tushar Ahmed Shishir
2. Taslimun Jannat
3. Iftekhar Bin Naser

Reviewed by ScreenIT

Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis

1. Ohad Yogev
2. Omer Weissbrod
3. Giorgia Battistoni
4. Dario Bressan
5. Adi Naamti
6. Ilaria Falciatori
7. Ahmet C. Berkyurek
8. Roni Rasnic
9. Myra Hosmillo
10. Shaul Ilan
11. Iris Grossman
12. Lauren McCormick
13. Christopher C. Honeycutt
14. Timothy Johnston
15. Matthew Gagne
16. Daniel C. Douek
17. Ian Goodfellow
18. Gregory J. Hannon
19. Yaniv Erlich

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Independent acquisition of short insertions at the RIR1 site in the spike N‐terminal domain of the SARS‐CoV‐2 BA.2 lineage

1. Samuele Greco
2. Marco Gerdol

Reviewed by ScreenIT

Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

1. Iromi Wanigasuriya
2. Sarah A. Kinkel
3. Tamara Beck
4. Ellise A. Roper
5. Kelsey Breslin
6. Heather J. Lee
7. Andrew Keniry
8. Matthew E. Ritchie
9. Marnie E. Blewitt
10. Quentin Gouil

• Curated by eLife

  Evaluation Summary:

  This study assess the role of SMCHD1 provided by the oocyte at fertilization in the regulation of Xist expression in the embryo. They also provide preliminary analysis of the downstream effects of faulty Xist expression, on X chromosome silencing. This work has implications in epigenetics and embryonic development and aims at an audience interested in gene dosage regulation in mammals. Although of potential interest, some further analytical and experimental work is needed to understand how SMHCD1 works on the early stages of X inactivation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The haplotype-resolved chromosome pairs and transcriptome of a heterozygous diploid African cassava cultivar

1. Weihong Qi
2. Yi-Wen Lim
3. Andrea Patrignani
4. Pascal Schläpfer
5. Anna Bratus-Neuenschwander
6. Simon Grüter
7. Christelle Chanez
8. Nathalie Rodde
9. Elisa Prat
10. Sonia Vautrin
11. Margaux-Alison Fustier
12. Diogo Pratas
13. Ralph Schlapbach
14. Wilhelm Gruissem

Reviewed by GigaScience