Genetics

DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

1. Hilda Tateossian
2. Amy Southern
3. Pratik Vikhe
4. Eva Lana-Elola
5. Sheona Watson-Scales
6. Dorota Gibbins
7. Debbie Williams
8. Thomas Purnell
9. Philomena Mburu
10. Andrew Parker
11. Dominic P Norris
12. Regie Lyn P Santos-Cortez
13. Brian W Herrmann
14. Sara Wells
15. Heena V Lad
16. Elizabeth MC Fisher
17. Victor LJ Tybulewicz
18. Steve DM Brown

• Curated by eLife

  eLife Assessment

  This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting DYRK1A as a promising therapeutic target for addressing hearing loss in patients with Down syndrome.

Reviewed by eLife

An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

1. Jyotsna Kumar
2. Swati Haldar
3. Neelima Gupta
4. Viney Kumar
5. Manisha Thakur
6. Keerthivasan Raanin Chandradoss
7. Debarghya Ghose
8. Dipak Dutta
9. Kuljeet Singh Sandhu
10. Jagmohan Singh

• Curated by eLife

  eLife Assessment

  This study aims to investigate the RNA binding activities of a conserved heterochromatin protein (Swi6) and proposes an entirely new model for how heterochromatin formation is initiated in fission yeast. While the concept is interesting, the data provided are inadequate, both for support of the claims regarding the new RNA binding activities and for support of the new model. The paper requires extensive editing as well as the inclusion of numerous experiments with appropriately controlled conditions.

Reviewed by eLife

The Drosophila maternal-effect gene abnormal oocyte ( ao ) does not repress histone gene expression

1. Risa Takenaka
2. Eric H Albanese
3. Sierra M Simmerman
4. Shilpi Verghese
5. Mandalay A E Maddox
6. Aida Flor de la Cruz
7. Janet M Young
8. Casey A Schmidt
9. Leila E Rieder
10. Harmit S Malik

Reviewed by Review Commons