Genetics

Lack of evidence supporting transgenerational effects of non-transmitted paternal alleles on the murine transcriptome

1. Rodrigo Gularte-Mérida
2. Carole Charlier
3. Michel Georges

• Curated by eLife

  eLife assessment

  This important article presents the results of a large screen for non-genetic transgenerational effects that may influence gene expression and other phenotypes in mice. An extraordinary amount of mouse breeding, phenotyping, and RNA sequencing data provide compelling evidence that, for the phenotypes and genomic regions interrogated in these mouse strains, non-genetic transgenerational effects of appreciable magnitude are likely to be extremely rare. This paper will be of broad interest to geneticists and of particular interest to those studying epigenetic inheritance.

Reviewed by eLife

Exploring functional conservation in silico : a new machine learning approach to RNA-editing

1. Michał Zawisza-Álvarez
2. Jesús Peñuela-Melero
3. Esteban Vegas
4. Ferran Reverter
5. Jordi Garcia-Fernàndez
6. Carlos Herrera-Úbeda

Reviewed by Review Commons

Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

1. Lauren Kuffler
2. Daniel A Skelly
3. Anne Czechanski
4. Haley J Fortin
5. Steven C Munger
6. Christopher L Baker
7. Laura G Reinholdt
8. Gregory W Carter

• Curated by eLife

  eLife assessment

  This important manuscript reports interactions between genetic variation, DNA accessibility, and chromatin structure in gene expression at a genome wide scale. The authors found that most of these interactions occur within topologically associating domains (TADs) and 3D genome structure data can be efficiently used to guide the discovery of significant genetic and epigenetic influences on gene expression. Overall, this convincing study highlights the importance of 3D chromatin structure in controlling how gene expression is regulated by genetic and epigenetic processes.

Reviewed by eLife

Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

1. Mitchell Bestry
2. Alexander N Larcombe
3. Nina Kresoje
4. Emily K Chivers
5. Chloe Bakker
6. James P Fitzpatrick
7. Elizabeth J Elliott
8. Jeffrey M Craig
9. Evelyne Muggli
10. Jane Halliday
11. Delyse Hutchinson
12. Sam Buckberry
13. Ryan Lister
14. Martyn Symons
15. David Martino

• Curated by eLife

  eLife assessment

  This important study unveils the significant impact of prenatal alcohol exposure on epigenetic patterns, offering new insights into its adverse health outcomes through solid evidence from both mouse models and human data. The findings, which reveal how a high-methyl diet can mitigate these epigenetic alterations, present a promising prenatal care strategy. Despite its solid data overall, the study's small sample size and unaccounted confounders suggest the need for further research to confirm these findings and explore their practical implications.

Reviewed by eLife

Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

1. Can Hu
2. Xue-Ting Zhu
3. Ming-Hong He
4. Yangyang Shao
5. Zhongjun Qin
6. Zhi-Jing Wu
7. Jin-Qiu Zhou

• Curated by eLife

  eLife assessment

  This important study advances our understanding of the biological significance of the DNA sequence adjacent to telomeres. The data presented convincingly demonstrate that subtelomeric repeats are non-essential and have a minimal, if any, role in maintaining telomere integrity of budding yeast. The work will be of interest to the telomere community specifically and the genome integrity community more broadly.

Reviewed by eLife

Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

1. Weichen Song
2. Yongyong Shi
3. Guan Ning Lin

• Curated by eLife

  eLife assessment

  This valuable paper presents a new approach for association testing, using the output of neural networks that have been trained to predict functional changes from DNA sequences. As such, the approach is an interesting addition to statistical genetics, and the evidence for the presented method being able to identify trait-associations in regions where GWASs are typically underpowered is solid. A limitation is, however, that it is unclear how the quality of these associations compares to those detected using conventional methods. Additional work assessing this method's power and characterizing false positives / false negative regions would be critical to ensure that the method is broadly adopted by the field.

Reviewed by eLife

Allelic and Gene Dosage Effects Involving Uromodulin Aggregates Drive Autosomal Dominant Tubulointerstitial Kidney Disease

1. Guglielmo Schiano
2. Jennifer Lake
3. Marta Mariniello
4. Céline Schaeffer
5. Marianne Harvent
6. Luca Rampoldi
7. Eric Olinger
8. Olivier Devuyst

Reviewed by Review Commons

An adapted MS2-MCP system to visualize endogenous cytoplasmic mRNA with live imaging in Caenorhabditis elegans

1. Cristina Tocchini
2. Susan E. Mango

Reviewed by Review Commons

A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

1. Emily I Green
2. Etienne Jaouen
3. Dennis Klug
4. Roenick Proveti Olmo
5. Amandine Gautier
6. Stéphanie Blandin
7. Eric Marois

Reviewed by Review Commons

Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions

1. Kento Morimoto
2. Hayate Suzuki
3. Akihiro Kuno
4. Yoko Daitoku
5. Yoko Tanimoto
6. Kanako Kato
7. Kazuya Murata
8. Fumihiro Sugiyama
9. Seiya Mizuno

Reviewed by Review Commons