Genetic and Genomic Medicine

  1. Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study

    1. Laurence J Howe
    2. Ben Brumpton
    3. Humaira Rasheed
    4. Bjørn Olav Åsvold
    5. George Davey Smith
    6. Neil M Davies

    • Curated by eLife

      Evaluation Summary:

      The authors examined the role of height in cancer, coronary heart disease and cardiovascular disease risk factors, using four different designs. They found that height increases risk of cancer and decreases risk of coronary heart disease, while the associations for the cardiovascular disease risk factors were largely null. This will be mainly of interest to epidemiologists.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

    1. Bożena Bruhn-Olszewska
    2. Hanna Davies
    3. Daniil Sarkisyan
    4. Ulana Juhas
    5. Edyta Rychlicka-Buniowska
    6. Magdalena Wójcik
    7. Monika Horbacz
    8. Marcin Jąkalski
    9. Paweł Olszewski
    10. Jakub O. Westholm
    11. Agata Smialowska
    12. Karol Wierzba
    13. Åsa Torinsson Naluai
    14. Niklas Jern
    15. Lars-Magnus Andersson
    16. Josef D. Järhult
    17. Natalia Filipowicz
    18. Eva Tiensuu Janson
    19. Sten Rubertsson
    20. Miklós Lipcsey
    21. Magnus Gisslén
    22. Michael Hultström
    23. Robert Frithiof
    24. Jan P. Dumanski

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

    1. Maik Pietzner
    2. Robert Lorenz Chua
    3. Eleanor Wheeler
    4. Katharina Jechow
    5. Julian D. S. Willett
    6. Helena Radbruch
    7. Saskia Trump
    8. Bettina Heidecker
    9. Hugo Zeberg
    10. Frank L. Heppner
    11. Roland Eils
    12. Marcus A. Mall
    13. J. Brent Richards
    14. Leif-Erik Sander
    15. Irina Lehmann
    16. Sören Lukassen
    17. Nicholas J. Wareham
    18. Christian Conrad
    19. Claudia Langenberg

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. EFCAB4B (CRACR2A) genetic variants associated with COVID-19 fatality

    1. Dapeng Wang
    2. Sabina D Wiktor
    3. Chew W Cheng
    4. Katie J Simmons
    5. Ashley Money
    6. Lucia Pedicini
    7. Asya Carlton
    8. Alexander L Breeze
    9. Lynn McKeown

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. A novel gene ZNF862 causes hereditary gingival fibromatosis

    1. Juan Wu
    2. Dongna Chen
    3. Hui Huang
    4. Ning Luo
    5. Huishuang Chen
    6. Junjie Zhao
    7. Yanyan Wang
    8. Tian Zhao
    9. Siyuan Huang
    10. Yang Ren
    11. Teng Zhai
    12. Weibin Sun
    13. Houxuan Li
    14. Wei Li

    • Curated by eLife

      Evaluation Summary:

      This work is of clinical relevance to those interested in the etiology and pathology of hereditary gingival fibromatosis (HGF). The paper discusses two novel findings: identification of a causative role of a missense mutation in the gene encoding the zinc finger protein 862 (ZNF862) that leads to hereditary gingival fibromatosis (HGF), a rare disease characterized by overgrowth of gingivae, in an examined family, and a suggestion of the molecular consequences of that mutation that leads to the disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic

    1. Wael H. Roshdy
    2. Mohamed K. Khalifa
    3. James Emmanuel San
    4. Houriiyah Tegally
    5. Eduan Wilkinson
    6. Shymaa Showky
    7. Darren Patrick Martin
    8. Monika Moir
    9. Amel Naguib
    10. Nancy Elguindy
    11. Mokhtar R. Gomaa
    12. Manal Fahim
    13. Hanaa Abu Elsood
    14. Amira Mohsen
    15. Ramy Galal
    16. Mohamed Hassany
    17. Richard J. Lessells
    18. Ahmed A. Al-Karmalawy
    19. Rabeh EL-Shesheny
    20. Ahmed M. Kandeil
    21. Mohamed A. Ali
    22. Tulio de Oliveira

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Amplicon-based nanopore minion sequencing of patients with COVID-19 omicron variant from India

    1. Somesh Kumar
    2. Avinash Lomash
    3. Mohammed Faruq
    4. Oves Siddiqui
    5. Suresh Kumar
    6. Seema Kapoor
    7. Prashanth Suravajhala
    8. Sunil K Polipalli
    9. SCOG_MAMC_ LNH

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Tracking mutational semantics of SARS-CoV-2 genomes

    1. Rohan Singh
    2. Sunil Nagpal
    3. Nishal K. Pinna
    4. Sharmila S. Mande

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Minimal observed impact of HLA genotype on hospitalization and severity of SARS‐CoV ‐2 infection

    1. Austin Nguyen
    2. Tasneem Yusufali
    3. Jill A. Hollenbach
    4. Abhinav Nellore
    5. Reid F. Thompson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. The Omicron variant mutation at position 28,311 in the SARS-CoV-2 N gene does not perturb CDC N1 target detection

    1. Yanxia Bei
    2. Kyle B. Vrtis
    3. Janine G. Borgaro
    4. Bradley W. Langhorst
    5. Nicole M. Nichols

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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