Genetic and Genomic Medicine

Androgen receptor polyQ alleles and COVID‐19 severity in men: A replication study

1. Rosario López‐Rodríguez
2. Javier Ruiz‐Hornillos
3. Marta Cortón
4. Berta Almoguera
5. Pablo Minguez
6. María Elena Pérez‐Tomás
7. María Barreda‐Sánchez
8. Esther Mancebo
9. Lorena Ondo
10. Andrea Martínez‐Ramas
11. Lidia Fernández‐Caballero
12. Juan Carlos Taracido‐Fernández
13. Antonio Herrero‐González
14. Ignacio Mahillo
15. The STOP_Coronavirus Study Group
16. Estela Paz‐Artal
17. Encarna Guillén‐Navarro
18. Carmen Ayuso

Reviewed by ScreenIT

Genetic Examination of Hematological Parameters in SARS-CoV-2 Infection and COVID-19

1. Bryce Rowland
2. Quan Sun
3. Wanjiang Wang
4. Tyne Miller-Fleming
5. Nancy Cox
6. Misa Graff
7. Annika Faucon
8. Megan M. Shuey
9. Elizabeth E. Blue
10. Paul Auer
11. Yun Li
12. Vijay G. Sankaran
13. Alexander P. Reiner
14. Laura M. Raffield

Reviewed by ScreenIT

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

1. Yunlong Ma
2. Fei Qiu
3. Chunyu Deng
4. Jingjing Li
5. Yukuan Huang
6. Zeyi Wu
7. Yijun Zhou
8. Yaru Zhang
9. Yichun Xiong
10. Yinghao Yao
11. Yigang Zhong
12. Jia Qu
13. Jianzhong Su

Reviewed by ScreenIT

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study

1. Laurence J Howe
2. Ben Brumpton
3. Humaira Rasheed
4. Bjørn Olav Åsvold
5. George Davey Smith
6. Neil M Davies

• Curated by eLife

  Evaluation Summary:

  The authors examined the role of height in cancer, coronary heart disease and cardiovascular disease risk factors, using four different designs. They found that height increases risk of cancer and decreases risk of coronary heart disease, while the associations for the cardiovascular disease risk factors were largely null. This will be mainly of interest to epidemiologists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

1. Bożena Bruhn-Olszewska
2. Hanna Davies
3. Daniil Sarkisyan
4. Ulana Juhas
5. Edyta Rychlicka-Buniowska
6. Magdalena Wójcik
7. Monika Horbacz
8. Marcin Jąkalski
9. Paweł Olszewski
10. Jakub O. Westholm
11. Agata Smialowska
12. Karol Wierzba
13. Åsa Torinsson Naluai
14. Niklas Jern
15. Lars-Magnus Andersson
16. Josef D. Järhult
17. Natalia Filipowicz
18. Eva Tiensuu Janson
19. Sten Rubertsson
20. Miklós Lipcsey
21. Magnus Gisslén
22. Michael Hultström
23. Robert Frithiof
24. Jan P. Dumanski

Reviewed by ScreenIT

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

1. Maik Pietzner
2. Robert Lorenz Chua
3. Eleanor Wheeler
4. Katharina Jechow
5. Julian D. S. Willett
6. Helena Radbruch
7. Saskia Trump
8. Bettina Heidecker
9. Hugo Zeberg
10. Frank L. Heppner
11. Roland Eils
12. Marcus A. Mall
13. J. Brent Richards
14. Leif-Erik Sander
15. Irina Lehmann
16. Sören Lukassen
17. Nicholas J. Wareham
18. Christian Conrad
19. Claudia Langenberg

Reviewed by ScreenIT

EFCAB4B (CRACR2A) genetic variants associated with COVID-19 fatality

1. Dapeng Wang
2. Sabina D Wiktor
3. Chew W Cheng
4. Katie J Simmons
5. Ashley Money
6. Lucia Pedicini
7. Asya Carlton
8. Alexander L Breeze
9. Lynn McKeown

Reviewed by ScreenIT

A novel gene ZNF862 causes hereditary gingival fibromatosis

1. Juan Wu
2. Dongna Chen
3. Hui Huang
4. Ning Luo
5. Huishuang Chen
6. Junjie Zhao
7. Yanyan Wang
8. Tian Zhao
9. Siyuan Huang
10. Yang Ren
11. Teng Zhai
12. Weibin Sun
13. Houxuan Li
14. Wei Li

• Curated by eLife

  Evaluation Summary:

  This work is of clinical relevance to those interested in the etiology and pathology of hereditary gingival fibromatosis (HGF). The paper discusses two novel findings: identification of a causative role of a missense mutation in the gene encoding the zinc finger protein 862 (ZNF862) that leads to hereditary gingival fibromatosis (HGF), a rare disease characterized by overgrowth of gingivae, in an examined family, and a suggestion of the molecular consequences of that mutation that leads to the disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic

1. Wael H. Roshdy
2. Mohamed K. Khalifa
3. James Emmanuel San
4. Houriiyah Tegally
5. Eduan Wilkinson
6. Shymaa Showky
7. Darren Patrick Martin
8. Monika Moir
9. Amel Naguib
10. Nancy Elguindy
11. Mokhtar R. Gomaa
12. Manal Fahim
13. Hanaa Abu Elsood
14. Amira Mohsen
15. Ramy Galal
16. Mohamed Hassany
17. Richard J. Lessells
18. Ahmed A. Al-Karmalawy
19. Rabeh EL-Shesheny
20. Ahmed M. Kandeil
21. Mohamed A. Ali
22. Tulio de Oliveira

Reviewed by ScreenIT

Amplicon-based nanopore minion sequencing of patients with COVID-19 omicron variant from India

1. Somesh Kumar
2. Avinash Lomash
3. Mohammed Faruq
4. Oves Siddiqui
5. Suresh Kumar
6. Seema Kapoor
7. Prashanth Suravajhala
8. Sunil K Polipalli
9. SCOG_MAMC_ LNH

Reviewed by ScreenIT