Epidemiology

Blurred molecular epidemiological lines between the two dominant methicillin-resistant Staphylococcus aureus clones

1. Amy C. Dupper
2. Mitchell J. Sullivan
3. Kieran I. Chacko
4. Aaron Mishkin
5. Brianne Ciferri
6. Ajay Kumaresh
7. Ana Berbel Caban
8. Irina Oussenko
9. Colleen Beckford
10. Nathalie E. Zeitouni
11. Robert Sebra
12. Camille Hamula
13. Melissa Smith
14. Andrew Kasarskis
15. Gopi Patel
16. Russell B. McBride
17. Harm van Bakel
18. Deena R. Altman

Reviewed by Review Commons

Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study

1. Qing Shen
2. Huan Song
3. Thor Aspelund
4. Jingru Yu
5. Donghao Lu
6. Jóhanna Jakobsdóttir
7. Jacob Bergstedt
8. Lu Yi
9. Patrick Sullivan
10. Arvid Sjölander
11. Weimin Ye
12. Katja Fall
13. Fang Fang
14. Unnur Valdimarsdóttir

• Curated by eLife

  Evaluation Summary:

  This is a useful quantification of the links of vascular disease on the development of subsequent mental health issues. It uses a robust dataset to quantify this association. Further work to focus the analyses, ensure claims are supported by the data, and consider alternative explanations is needed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

1. Amanda M Hughes
2. Eleanor Sanderson
3. Tim Morris
4. Ziada Ayorech
5. Martin Tesli
6. Helga Ask
7. Ted Reichborn-Kjennerud
8. Ole A Andreassen
9. Per Magnus
10. Øyvind Helgeland
11. Stefan Johansson
12. Pål Njølstad
13. George Davey Smith
14. Alexandra Havdahl
15. Laura D Howe
16. Neil M Davies

• Curated by eLife

  Evaluation Summary:

  This paper uses a new statistical approach called within family Mendelian randomization and asserts that claims of childhood BMI affecting a range of psychiatric traits are unfounded and were mainly caused by confounders that this new approach is able to better identify and control for. They do find a role for maternal BMI on a child's risk for developing depression. The main issue raised is that they do not convincingly show if they do not replicate the old association of childhood BMI with a range of psychiatric traits due to their technique simply having lower power to detect the signal or due to a true lack of this effect.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The role of adolescent lifestyle habits in biological aging: A prospective twin study

1. Anna Kankaanpää
2. Asko Tolvanen
3. Aino Heikkinen
4. Jaakko Kaprio
5. Miina Ollikainen
6. Elina Sillanpää

• Curated by eLife

  eLife assessment

  This paper provides evidence that an unhealthy lifestyle during adolescence accelerates epigenetic age in adulthood, and that these associations are largely explained by the effect of shared genetic influences. The main strengths of this valuable paper are the relatively large sample size, longitudinal assessment of lifestyle factors, and sophisticated statistical analyses. The paper is methodologically compelling and will be of interest for a broad audience, including individuals working on methylation, epidemiology, and/or ageing.

Reviewed by eLife

Nationwide mammography screening participation in Denmark during the COVID-19 pandemic: An observational study

1. Tina Bech Olesen
2. Henry Jensen
3. Henrik Møller
4. Jens Winther Jensen
5. Berit Andersen
6. Ilse Vejborg
7. Sisse H Njor

• Curated by eLife

  eLife assessment

  This article is of broad interest to public health researchers and to health policymakers in populations with national screening programs. It provides important knowledge on the impact of the COVID-19 pandemic on participation in mammography screening in Denmark by socio-economic indicators. The study provides convincing evidence for how the pandemic exacerbated disparities in breast cancer screening in Denmark.

Reviewed by eLife

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

1. Tom G Richardson
2. Grace M Power
3. George Davey Smith

• Curated by eLife

  Evaluation Summary:

  This manuscript is of broad interest to readers in the fields of vitamin D and obesity. It utilises a Mendelian randomization framework to separate the genetically predicted effects of adiposity at two timepoints in the lifecourse, childhood and adulthood. The key claims of the manuscript are well supported by the data. Higher childhood body size had a direct effect on lower vitamin D levels in early life, while in midlife, childhood body size impacted on adult obesity to result in lower vitamin D levels.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

1. Thiery Masserey
2. Tamsin Lee
3. Monica Golumbeanu
4. Andrew J Shattock
5. Sherrie L Kelly
6. Ian M Hastings
7. Melissa A Penny

• Curated by eLife

  Evaluation Summary:

  This manuscript explores the establishment and spread of antimalarial drug-resistant P. falciparum parasites using a combination of transmission modeling and model emulation. The authors add an important component to the broader understanding by jointly considering multiple factors driving drug resistance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

1. Fei Chen
2. Burcu F Darst
3. Ravi K Madduri
4. Alex A Rodriguez
5. Xin Sheng
6. Christopher T Rentsch
7. Caroline Andrews
8. Wei Tang
9. Adam S Kibel
10. Anna Plym
11. Kelly Cho
12. Mohamed Jalloh
13. Serigne Magueye Gueye
14. Lamine Niang
15. Olufemi J Ogunbiyi
16. Olufemi Popoola
17. Akindele O Adebiyi
18. Oseremen I Aisuodionoe-Shadrach
19. Hafees O Ajibola
20. Mustapha A Jamda
21. Olabode P Oluwole
22. Maxwell Nwegbu
23. Ben Adusei
24. Sunny Mante
25. Afua Darkwa-Abrahams
26. James E Mensah
27. Andrew Anthony Adjei
28. Halimatou Diop
29. Joseph Lachance
30. Timothy R Rebbeck
31. Stefan Ambs
32. J Michael Gaziano
33. Amy C Justice
34. David V Conti
35. Christopher A Haiman

• Curated by eLife

  Evaluation Summary:

  This paper is mainly for an audience of genetic epidemiologists interested in the evaluation and portability of polygenic scores. The authors show that a polygenic risk score to predict prostate cancer risk is very informative for individuals that are classified on three different ancestry categories. The authors show that the polygenic risk score can be used to predict the risk to develop prostate cancer as a function of age. This paper provides evidence that genetic information could be used to provide guidance to clinicians on when to perform screenings to detect prostate cancer in patients.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Societal COVID-19 epidemic counter measures and activities associated with SARS-CoV-2 infection in an adult unvaccinated population – a case-control study in Denmark, June 2021

1. Pernille Kold Munch
2. Laura Espenhain
3. Christian Holm Hansen
4. Tyra Grove Krause
5. Steen Ethelberg

Reviewed by ScreenIT

One Million and Counting: Estimates of Deaths in the United States from Ancestral SARS-CoV-2 and Variants

1. Jo Walker
2. Nathan D. Grubaugh
3. Gregg Gonsalves
4. Virginia Pitzer
5. Zain Rizvi

Reviewed by ScreenIT