Endocrinology (including Diabetes Mellitus and Metabolic Disease)

Hepatic Transthyretin knockdown alleviates NAFLD by enhancing SERCA2 function and inhibiting endoplasmic reticulum stress

1. Yingzi He
2. Tian Yang
3. Ruojun Qiu
4. Bingyang Liu
5. Shuo Wang
6. Jianan Wang
7. Fenping Zheng

• Curated by eLife

  eLife Assessment

  This potentially important study examines the consequences of manipulating the expression of thyroxine-binding and amyloidogenic hepatocyte secretory protein transthyretin (TTR). Solid in vivo evidence from two dietary models supports that TTR production exacerbates liver injury, whereas the evidence for a link between TTR production, uptake, and calcium dysregulation is incomplete. If the findings are confirmed, they would provide evidence for a novel cell biological pathway of liver injury.

Reviewed by eLife

Remission of type 2 diabetes can be achieved in short and long-lasting type 2 diabetes: results of a randomized controlled trial in individuals with overweight and obesity

1. Bettina Schuppelius
2. Elena Lalama
3. Jiudan Zhang
4. Kilian Rüther
5. Marta Csanalosi
6. Stefan Kabisch
7. Anette Christ
8. Eicke Latz
9. Olga Pivovarova-Ramich
10. Knut Mai
11. Andreas F. H. Pfeiffer

Reviewed by PREreview

Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

1. Yong Fan
2. Jiajun Ying
3. Ning Huangfu
4. Kewan He
5. Teng Hu
6. Pengpeng Su
7. Xintao Hu
8. Hequn He
9. Wei Liang
10. Junsong Liu
11. Jinsong Cheng
12. Shiqi Wang
13. Ruochi Zhao
14. Hengyi Mao
15. Fuwei He
16. Jia Su
17. Honglin Zhou
18. Zhenwei Li
19. Xiaohong Fei
20. Xiafei Sun
21. Peipei Wang
22. Minfang Guan
23. Weiping Du
24. Shaoyi Lin
25. Yong Wang
26. Fangkun Yang
27. Renyuan Fang
28. Ziqing Kong
29. Xiaomin Chen
30. Hanbin Cui

• Curated by eLife

  eLife assessment

  This study provides valuable information about the microbiome and metabolome, and their correlation with acute myocardial infarction. However, the relationship established between these variables is limited to a correlation, and therefore the strength of the evidence is incomplete.

Reviewed by eLife