1. Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease

    This article has 8 authors:
    1. Edwin A Homan
    2. Ankit Gilani
    3. Alfonso Rubio-Navarro
    4. Maya Johnson
    5. Eric Cortada
    6. Renan Pereira de Lima
    7. Lisa Stoll
    8. James C Lo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study investigates the role of Complement 3a Receptor 1 (C3aR) in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using mouse models with specific target deletions in various cell types. While the relevance of C3aR in inflammatory contexts has been established, the authors provide helpful but incomplete evidence that C3aR does not contribute significantly to MASLD pathogenesis in their models, a claim that would require additional experiments for support.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

    This article has 15 authors:
    1. GL Barlow
    2. CM Schürch
    3. SS Bhate
    4. D Phillips
    5. A Young
    6. S Dong
    7. HA Martinez
    8. G Kaber
    9. N Nagy
    10. S Ramachandran
    11. J Meng
    12. E Korpos
    13. JA Bluestone
    14. GP Nolan
    15. PL Bollyky
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study advances our understanding of the histopathological features of type 1 diabetes, in particular in regard to the composition and spatial organization of pancreas infiltrating immune cells. The evidence supporting the conclusions is convincingly grounded in an application of both state-of-the-art high-dimensional in situ immunostaining technology as well as a tailored image analysis strategy. The work will be of broad interest to type 1 diabetes researchers as it contributes to a better understanding of the disease's etiopathology.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  3. Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

    This article has 30 authors:
    1. Yong Fan
    2. Jiajun Ying
    3. Ning Huangfu
    4. Kewan He
    5. Teng Hu
    6. Pengpeng Su
    7. Xintao Hu
    8. Hequn He
    9. Wei Liang
    10. Junsong Liu
    11. Jinsong Cheng
    12. Shiqi Wang
    13. Ruochi Zhao
    14. Hengyi Mao
    15. Fuwei He
    16. Jia Su
    17. Honglin Zhou
    18. Zhenwei Li
    19. Xiaohong Fei
    20. Xiafei Sun
    21. Peipei Wang
    22. Minfang Guan
    23. Weiping Du
    24. Shaoyi Lin
    25. Yong Wang
    26. Fangkun Yang
    27. Renyuan Fang
    28. Ziqing Kong
    29. Xiaomin Chen
    30. Hanbin Cui
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable information about the microbiome and metabolome, and their correlation with acute myocardial infarction. However, the relationship established between these variables is limited to a correlation, and therefore the strength of the evidence is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes

    This article has 11 authors:
    1. Jiang Li
    2. Yuefeng Yu
    3. Ying Sun
    4. Yanqi Fu
    5. Wenqi Shen
    6. Lingli Cai
    7. Xiao Tan
    8. Yan Cai
    9. Ningjian Wang
    10. Yingli Lu
    11. Bin Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study combines prospective cohort, metabolomics and machine learning to identify a panel of nine circulating metabolites that improved the ability in risk prediction of progression from prediabetes to diabetes. The findings are convincing, and using current state-of-the-art methods the data and analyses support the claims. This paper provides insights into the integration of these metabolites into clinical and public health practice.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    This article has 27 authors:
    1. Khanh B. Trang
    2. Matthew C. Pahl
    3. James A. Pippin
    4. Chun Su
    5. Sheridan H. Littleton
    6. Prabhat Sharma
    7. Nikhil N. Kulkarni
    8. Louis R. Ghanem
    9. Natalie A. Terry
    10. Joan M. O’Brien
    11. Yadav Wagley
    12. Kurt D. Hankenson
    13. Ashley Jermusyk
    14. Jason W. Hoskins
    15. Laufey T. Amundadottir
    16. Mai Xu
    17. Kevin M Brown
    18. Stewart A. Anderson
    19. Wenli Yang
    20. Paul M. Titchenell
    21. Patrick Seale
    22. Laura Cook
    23. Megan K. Levings
    24. Babette S. Zemel
    25. Alessandra Chesi
    26. Andrew D. Wells
    27. Struan F.A. Grant
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents genome-wide high-resolution chromatin-based 3D genomic interaction maps for over 50 diverse human cell types and integrates these data with pediatric obesity GWAS. The work provides convincing evidence that multiple pancreatic islet cell types are key effector cell types. The authors also perform variant-to-gene mapping to nominate genes underlying several GWAS hits. Overall, the results will be of interest to bth the fields of 3D genome architecture and pediatric obesity.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    This article has 17 authors:
    1. Sindre Lee-Ødegård
    2. Marit Hjorth
    3. Thomas Olsen
    4. Gunn-Helen Moen
    5. Emily Daubney
    6. David M Evans
    7. Andrea L Hevener
    8. Aldons J Lusis
    9. Mingqi Zhou
    10. Marcus M Seldin
    11. Hooman Allayee
    12. James Hilser
    13. Jonas Krag Viken
    14. Hanne Gulseth
    15. Frode Norheim
    16. Christian A Drevon
    17. Kåre Inge Birkeland
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful manuscript describes a proteomic analysis of plasma from subjects before and after an exercise regime consisting of endurance and resistance exercise. The work identifies a putative new exerkine, CD300LG, and finds associations of this protein with aspects of insulin sensitivity and angiogenesis. The characterization remains incomplete at present. Because CD300LG may have a transmembrane domain, one possibility is that exercise causes the release of extracellular vesicles containing this protein. As this study reports associations, additional studies will be needed to establish causality. The paper will hopefully prompt further studies to more fully elucidate the underlying biology.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

    This article has 10 authors:
    1. Qiong He
    2. Miao-Miao Zhao
    3. Ming-Jia Li
    4. Xiao-Ya Li
    5. Jian-Min Jin
    6. Ying-Mei Feng
    7. Li Zhang
    8. Wei Jin Huang
    9. Fangyuan Yang
    10. Jin-Kui Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study advances our understanding of why diabetes is a risk factor for more severe Covid-19 disease. The authors offer convincing evidence that cathepsin L is more active in diabetic individuals because of the presence of high glucose, where the main mechanism is increased cathepsin L maturation. This study should be of interest to researchers in diabetes, virology and immunology.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. The impact of surgery and oncological treatment on risk of type 2 diabetes onset in patients with colorectal cancer: nationwide cohort study in Denmark

    This article has 8 authors:
    1. Caroline Krag
    2. Maria Saur Svane
    3. Sten Madsbad
    4. Susanne Boel Graversen
    5. Jesper Frank Christensen
    6. Thorkild IA Sørensen
    7. Louise Lang Lehrskov
    8. Tinne Laurberg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study presents findings that suggest the need for postoperative type 2 diabetes screening and that this should be prioritized in colorectal cancer survivors with overweight/obesity regardless of the type of colorectal cancer treatment applied. The evidence supporting the claims of the authors is solid and the authors use a population-based cohort study including all Danish colorectal patients who had undergone colorectal cancer surgery between 2001-2018. The work will be of interest to medical biologists, endocrinologists and oncologists working on colorectal cancer.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  9. Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

    This article has 18 authors:
    1. Giulia Leanza
    2. Francesca Cannata
    3. Malak Faraj
    4. Claudio Pedone
    5. Viola Viola
    6. Flavia Tramontana
    7. Niccolò Pellegrini
    8. Gianluca Vadalà
    9. Alessandra Piccoli
    10. Rocky Strollo
    11. Francesca Zalfa
    12. Alec T Beeve
    13. Erica L Scheller
    14. Simon Y Tang
    15. Roberto Civitelli
    16. Mauro Maccarrone
    17. Rocco Papalia
    18. Nicola Napoli
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable insights into understanding bone fragility in T2D patients through the use of human skeletal tissue, reinforcing previous pre-clinical studies or observational studies using serum samples that the Wnt signaling pathway may play a critical role in T2D-related bone impairment. The methods are solid, but a limited number of subjects and a small set of genes with lack of data in terms of cellular properties of skeletal tissue are viewed as weaknesses.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

    This article has 13 authors:
    1. Pianpian Zhao
    2. Zhifeng Sheng
    3. Lin Xu
    4. Peng Li
    5. Wenjin Xiao
    6. Chengda Yuan
    7. Zhanwei Xu
    8. Mengyuan Yang
    9. Yu Qian
    10. Jiadong Zhong
    11. Jiaxuan Gu
    12. David Karasik
    13. Hou-Feng Zheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study aims to explore the diabetes-bone paradox using the Mendelian Randomization approach. That diabetes itself is not the direct cause, but rather the complications or associated risk factors increase the risk of fracture, constitutes a valuable insight. Mendelian randomization to explain the relationship of two complex conditions is solid and conducted properly; however, the efforts to reconcile the discrepancies between the Mendelian Randomization analysis and observational studies are incomplete.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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