Developmental Biology

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

1. Liang-Yu Pang
2. Steven DeLuca
3. Haolong Zhu
4. John M Urban
5. Allan C Spradling

• Curated by eLife

  eLife assessment

  This important work significantly advances our comprehension of the molecular events occurring during germline stem cell differentiation in the Drosophila melanogaster ovary. The conclusions are strongly supported by compelling evidence, including rigorous data sets and complementary whole-genome analyses. As a result, this research holds substantial interest for developmental and stem cell biologists alike.

Reviewed by eLife

Supraclavicular brown adipocytes originate from Tbx1 ⁺ myoprogenitors

1. Zan Huang
2. Chenxin Gu
3. Zengdi Zhang
4. Rini Arianti
5. Aneesh Swaminathan
6. Kevin Tran
7. Alex Battist
8. Endre Kristóf
9. Hai-Bin Ruan

Reviewed by Review Commons

Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland

1. Qiang Lan
2. Ewelina Trela
3. Riitta Lindström
4. Jyoti Prabha Satta
5. Beata Kaczyńska
6. Mona M Christensen
7. Martin Holzenberger
8. Jukka Jernvall
9. Marja L Mikkola

Reviewed by Review Commons

Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

1. Tao Zhang
2. Liyang Wan
3. Han Xiao
4. Linfeng Wang
5. Jianzhong Hu
6. Hongbin Lu

• Curated by eLife

  eLife assessment

  This paper represents a valuable single-cell level analysis of tendon enthesis development. It will allow further understanding of this specific process with clinical implications. Specifically, the authors provided convincing evidence for the heterogeneity of postnatal enthesis growth and the molecular dynamics and signaling networks during enthesis formation.

Reviewed by eLife

Maternal adaptations in mouse lactation are vulnerable to diet-induced excess adiposity

1. Jessica A. Breznik
2. Tatiane A. Ribeiro
3. Erica Yeo
4. Brianna K. E. Kennelly
5. Xuanyu Wang
6. Candice Quin
7. Braeden Cowbrough
8. Elena F. Verdú
9. Dawn M. E. Bowdish
10. Deborah M. Sloboda

Reviewed by PREreview

CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development

1. Young Sun Hwang
2. Yasunari Seita
3. M. Andrés Blanco
4. Kotaro Sasaki

Reviewed by Review Commons

Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development

1. Denis F. Faerberg
2. Erin Z. Aprison
3. Ilya Ruvinsky

Reviewed by Arcadia Science

LINKIN-associated proteins necessary for tissue integrity during collective cell migration

1. Chieh-Hsiang Tan
2. Kai-Wen Cheng
3. Heenam Park
4. Tsui-Fen Chou
5. Paul W. Sternberg

Reviewed by Arcadia Science

Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

1. Wei Liu
2. Rupendra Shrestha
3. Albert Lowe
4. Xusheng Zhang
5. Ludovic Spaeth

• Curated by eLife

  eLife assessment

  In this important study, the authors present a human telencephalon-eye organoid model that exhibits remarkable pathfinding and growth of retinal ganglion cell (RGC) axons. The identification of cell-surface markers for RGCs could have value for understanding the molecular mechanisms involved in RGC axon development and regeneration. The strength of evidence is compelling for future studies to investigate RGC neurite outgrowth and brain-eye connectivity in humans.

Reviewed by eLife

Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts

1. Tyler A. Square
2. Emma J. Mackey
3. Shivani Sundaram
4. Naama C. Weksler
5. Zoe Z. Chen
6. Sujanya N. Narayanan
7. Craig T. Miller

Reviewed by Arcadia Science